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Gene Review

Aanat  -  arylalkylamine N-acetyltransferase

Mus musculus

Synonyms: AA-NAT, Aralkylamine N-acetyltransferase, Nat-2, Nat4, SNAT, ...
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Psychiatry related information on Aanat

  • Intraperitoneal cocaine treatment (10 and 20 mg/kg) dose-dependently increased locomotor activity of both normal (C3H/HeJ) and AANAT mutant (C57BL/6J) mice; this effect was similar during the day and at night [1].

High impact information on Aanat


Biological context of Aanat


Anatomical context of Aanat

  • The inhibitory transcription factor ICER is present in the pineal gland but with highest values when AANAT may be activated, suggesting the blockade takes place upstream of Aanat expression [7].
  • N-acetyltransferase activity toward the aromatic amine carcinogen 4-aminobiphenyl and O-acetyltransferase activity toward its proximate metabolite N-hydroxy-4-aminobiphenyl were both present in tissue cytosols of WT mice but were undetectable in Nat2 KO mice [11].
  • It was proposed that NAS could be a mediator of the antidepressant action of drugs, and it was shown that chronic but not acute treatment of rats with the antidepressant fluoxetine increases the content of AANAT mRNA in the rat hippocampus [5].

Associations of Aanat with chemical compounds


Other interactions of Aanat

  • The molecular linkage analysis demonstrated that the gene encoding SNAT maps 1.5 cM distal to D11Mit11 [12].
  • We observed that mice with both outer-retinal degeneration and a deficiency in melanopsin exhibited complete loss of photoentrainment of the circadian oscillator, pupillary light responses, photic suppression of arylalkylamine-N-acetyltransferase transcript, and acute suppression of locomotor activity by light [13].

Analytical, diagnostic and therapeutic context of Aanat


  1. Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase. Uz, T., Javaid, J.I., Manev, H. Life Sci. (2002) [Pubmed]
  2. Transcriptional control of circadian hormone synthesis via the CREM feedback loop. Foulkes, N.S., Borjigin, J., Snyder, S.H., Sassone-Corsi, P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Arylamine N-acetyltransferase from chicken liver. I. Monoclonal antibodies, immunoaffinity purification, and amino acid sequences. Deguchi, T., Sakamoto, Y., Sasaki, Y., Uyemura, K. J. Biol. Chem. (1988) [Pubmed]
  4. Role of calcium in the gating of isoproterenol-induced arylalkylamine N-acetyltransferase gene expression in the mouse pineal gland. Chansard, M., Liang, J., Iwahana, E., Baker, T., Whittaker, J., Fukuhara, C. J. Pineal Res. (2006) [Pubmed]
  5. Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice. Uz, T., Manev, H. J. Pineal Res. (2001) [Pubmed]
  6. The locus controlling pineal serotonin N-acetyltransferase activity (Nat-2) is located on mouse chromosome 11. Goto, M., Oshima, I., Hasegawa, M., Ebihara, S. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  7. Rat and Syrian hamster: two models for the regulation of AANAT gene expression. Simonneaux, V., Sinitskaya, N., Salingre, A., Garidou, M.L., Pévet, P. Chronobiol. Int. (2006) [Pubmed]
  8. Molecular cloning of serotonin N-acetyltransferase gene from the mouse and its daily expression in the retina. Sakamoto, K., Ishida, N. Neurosci. Lett. (1998) [Pubmed]
  9. Pineal circadian clocks gate arylalkylamine N-acetyltransferase gene expression in the mouse pineal gland. Fukuhara, C., Yamazaki, S., Liang, J. J. Neurochem. (2005) [Pubmed]
  10. Transcription factor dynamics and neuroendocrine signalling in the mouse pineal gland: a comparative analysis of melatonin-deficient C57BL mice and melatonin-proficient C3H mice. von Gall, C., Lewy, A., Schomerus, C., Vivien-Roels, B., Pevét, P., Korf, H.W., Stehle, J.H. Eur. J. Neurosci. (2000) [Pubmed]
  11. N-acetyltransferase (nat) 1 and 2 expression in nat2 knockout mice. Loehle, J.A., Cornish, V., Wakefield, L., Doll, M.A., Neale, J.R., Zang, Y., Sim, E., Hein, D.W. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  12. Chromosomal mapping of the gene encoding serotonin N-acetyltransferase to rat chromosome 10q32.3 and mouse chromosome 11E2. Yoshimura, T., Nagabukuro, A., Matsuda, Y., Suzuki, T., Kuroiwa, A., Iigo, M., Namikawa, T., Ebihara, S. Cytogenet. Cell Genet. (1997) [Pubmed]
  13. Melanopsin is required for non-image-forming photic responses in blind mice. Panda, S., Provencio, I., Tu, D.C., Pires, S.S., Rollag, M.D., Castrucci, A.M., Pletcher, M.T., Sato, T.K., Wiltshire, T., Andahazy, M., Kay, S.A., Van Gelder, R.N., Hogenesch, J.B. Science (2003) [Pubmed]
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