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Gene Review

AANAT  -  aralkylamine N-acetyltransferase

Bos taurus

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High impact information on AANAT


Biological context of AANAT


Anatomical context of AANAT


Associations of AANAT with chemical compounds


Analytical, diagnostic and therapeutic context of AANAT

  • Immunocytochemistry revealed that the changes in AANAT protein levels occurred in virtually all pinealocytes [1].
  • Northern blot analysis showed that Aanat mRNA levels did not change upon PMA treatment indicating that phorbol esters control AANAT at a post-transcriptional level [7].


  1. Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: an example from the pineal gland. Schomerus, C., Korf, H.W., Laedtke, E., Weller, J.L., Klein, D.C. J. Neurochem. (2000) [Pubmed]
  2. Characterization of dopaminergic receptor sites in bovine pineal gland. Govitrapong, P., Murrin, L.C., Ebadi, M. J. Pineal Res. (1984) [Pubmed]
  3. Characterization of D1 dopamine receptors in the bovine pineal gland with [3H]SCH 23390. Simonneaux, V., Murrin, L.C., Ebadi, M. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  4. Bovine arylalkylamine N-acetyltransferase activity correlated with mRNA expression in pineal and retina. Craft, C.M., Murage, J., Brown, B., Zhan-Poe, X. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  5. The kinetics of norepinephrine-induced stimulation of serotonin N-acetyltransferase in bovine pineal gland. Chan, A., Ebadi, M. Neuroendocrinology (1980) [Pubmed]
  6. Inhibitory actions of muscarinic cholinergic receptor agonists on serotonin N-acetyltransferase in bovine pineal explants in culture. Pujito, P.P., Govitrapong, P., Ebadi, M. Neurochem. Res. (1991) [Pubmed]
  7. Activation of arylalkylamine N-acetyltransferase by phorbol esters in bovine pinealocytes suggests a novel regulatory pathway in melatonin synthesis. Schomerus, C., Laedtke, E., Korf, H.W. J. Neuroendocrinol. (2004) [Pubmed]
  8. Sheep pineal beta-adrenoceptor function--interaction with gamma-aminobutyric acid. Foldes, A., Maxwell, C.A., Rintoul, A.J., Edols, R.W. Neuroendocrinology (1984) [Pubmed]
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