Disease relevance of cheD

• Like homologous sugar-binding proteins in Escherichia coli, ChvE was required for chemotaxis toward galactose and several other sugars [1].
• Swimming against the tide: chemotaxis in Agrobacterium [2].
• Characterization of a sugar-binding protein from Azospirillum brasilense mediating chemotaxis to and uptake of sugars [3].

High impact information on cheD

• A chromosomally-determined chemotaxis system causes the bacterium to be attracted into the rhizosphere by chemoattractants in plant exudates [2].
• Chemotaxis in bacteria is an excellent model for signal transduction processes [2].
• The protein, designated as SbpA (sugar binding protein A), is involved in the uptake of D-galactose and functions in the chemotaxis of A. brasilense towards several sugars, including D-galactose, L-arabinose and D-fucose [3].
• Downstream of traS is a gene encoding a truncated, defective chemoreceptor whose expression abolished chemotaxis [4].
• A. tumefaciens C58C1 containing Ti-plasmids with Tn5 insertions in virB, C, D or E exhibited marked chemotaxis towards acetosyringone [5].

Chemical compound and disease context of cheD

• virA and virG are the Ti-plasmid functions required for chemotaxis of Agrobacterium tumefaciens towards acetosyringone [5].
• The fragment was found to complement a G3DH mutant of A. tumefaciens and was also found to confer chemotaxis towards sucrose in E. coli [6].

Biological context of cheD

• Of the cosmid clones pVK219 (virAB) pVK221 (virBGC) pVK225 (virGCDE) and pVK257 (virABGC) mobilized to cured A. tumefaciens C58C1, only pVK257 bestowed acetosyringone chemotaxis. virA and virG are thus required for chemotaxis of A. tumefaciens towards acetosyringone [5].
• A strong correlation between vir-inducing ability and Ti plasmid requirement for chemotaxis is thus established [7].
• Requirement for chemotaxis in pathogenicity of Agrobacterium tumefaciens on roots of soil-grown pea plants [8].
• Characteristics of high sorbed-phase concentration, chemotaxis, and attachment of cells to soil particles seem to contribute to the bioavailability of soil-sorbed atrazine [9].
• We report the DNA sequence of a 9.6-kb region of the Agrobacterium tumefaciens chromosome containing a putative 8-kb chemotaxis operon [10].

Associations of cheD with chemical compounds

• We have found that R. meliloti RCR2011 exhibits positive chemotaxis towards luteolin [11].
• Insertion mutations in the palK and palE genes showed the necessity of these genes for bacterial growth and chemotaxis with palatinose as the carbon source, but no inhibition of tumorigenesis was observed [12].
• The acc locus from the Ti plasmid pTiC58 confers utilization of and chemotaxis toward agrocinopines A and B (A+B), as well as susceptibility to a highly specific antiagrobacterial antibiotic, agrocin 84 [13].
• The presence of naringenin but not apigenin abolished chemotaxis of R. meliloti towards luteolin [11].
• The determinants for chemotaxis to these opines were localized to the regions of the octopine- and nopaline-type Ti plasmids coding for transport and catabolism of that opine [14].

References