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Gene Review

Il5  -  interleukin 5

Mus musculus

Synonyms: B-cell growth factor II, BCGF-II, Cytotoxic T-lymphocyte inducer, Eosinophil differentiation factor, IL-5, ...
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Disease relevance of Il5


High impact information on Il5

  • T helper 2 (T(H)2) cells elaborate cytokines, such as interleukin (IL)-4, IL-5, IL-9 and IL-13, which work with toxic mediators of innate immune cells to establish environments that are inhospitable to helminth or arthropod invaders [6].
  • Interleukin-5 (IL-5) is a lineage-specific cytokine for eosinophilpoiesis and plays an important part in diseases associated with increased eosinophils, such as asthma [7].
  • The structure of IL-5 provides a molecular basis for the design of antagonists and agonists that would delineate receptor recognition determinants critical in signal transduction [7].
  • We have previously reported that IL-5-stimulated B cells are induced to express the 55K chain [8].
  • To elucidate the molecular properties of TRF we isolated cDNA encoding TRF from the 2.19 T-cell line and report here the structure and multiple activities of this lymphokine [9].

Chemical compound and disease context of Il5


Biological context of Il5


Anatomical context of Il5


Associations of Il5 with chemical compounds


Physical interactions of Il5


Regulatory relationships of Il5

  • In contrast, IL-5 did not affect steady state levels of germline transcripts stimulated by IL-4, but did markedly increase levels of productive gamma 1 and epsilon transcripts [29].
  • Conversely, the cells from the IL-3-induced blast cell colonies of the transgenic mice proliferated in response to either IL-3 or IL-5 [21].
  • Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively [21].
  • In contrast, recombinant IL-2 induced IL-5 mRNA expression but did not induce detectable expression of IL-4 or granulocyte-macrophage colony-stimulating factor mRNA [16].
  • These data imply that Lyn is involved in B cell triggering by CD38 ligation plus IL-5 for isotype switching [22].
  • These results suggest that IL-5-induced hypereosinophilia could suppress sensitization to Ag via a TGF-beta-dependent mechanism, thus suppressed allergic airway inflammation [30].

Other interactions of Il5


Analytical, diagnostic and therapeutic context of Il5


  1. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Kopf, M., Le Gros, G., Bachmann, M., Lamers, M.C., Bluethmann, H., Köhler, G. Nature (1993) [Pubmed]
  2. The pathobiology of bronchial asthma. Arm, J.P., Lee, T.H. Adv. Immunol. (1992) [Pubmed]
  3. Receptors for T cell-replacing factor/interleukin 5. Specificity, quantitation, and its implication. Mita, S., Harada, N., Naomi, S., Hitoshi, Y., Sakamoto, K., Akagi, M., Tominaga, A., Takatsu, K. J. Exp. Med. (1988) [Pubmed]
  4. Mechanisms regulating the mRNA levels of interleukin-5 and two other coordinately expressed lymphokines in the murine T lymphoma EL4.23. Naora, H., Young, I.G. Blood (1994) [Pubmed]
  5. Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common beta chain in children with acute myeloid leukemia associated with respiratory failure. Dirksen, U., Hattenhorst, U., Schneider, P., Schroten, H., Göbel, U., Böcking, A., Müller, K.M., Murray, R., Burdach, S. Blood (1998) [Pubmed]
  6. Helper T cells regulate type-2 innate immunity in vivo. Shinkai, K., Mohrs, M., Locksley, R.M. Nature (2002) [Pubmed]
  7. A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Milburn, M.V., Hassell, A.M., Lambert, M.H., Jordan, S.R., Proudfoot, A.E., Graber, P., Wells, T.N. Nature (1993) [Pubmed]
  8. Interleukins 4 and 5 control expression of IL-2 receptor on murine B cells through independent induction of its two chains. Loughnan, M.S., Nossal, G.J. Nature (1989) [Pubmed]
  9. Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. Kinashi, T., Harada, N., Severinson, E., Tanabe, T., Sideras, P., Konishi, M., Azuma, C., Tominaga, A., Bergstedt-Lindqvist, S., Takahashi, M. Nature (1986) [Pubmed]
  10. Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements. Siegel, M.D., Zhang, D.H., Ray, P., Ray, A. J. Biol. Chem. (1995) [Pubmed]
  11. Molecular properties and regulation of mRNA expression for murine T cell-replacing factor/IL-5. Tominaga, A., Matsumoto, M., Harada, N., Takahashi, T., Kikuchi, Y., Takatsu, K. J. Immunol. (1988) [Pubmed]
  12. Critical roles for interleukin-4 and interleukin-5 during respiratory syncytial virus infection in the development of airway hyperresponsiveness after airway sensitization. Schwarze, J., Cieslewicz, G., Joetham, A., Ikemura, T., Mäkelä, M.J., Dakhama, A., Shultz, L.D., Lamers, M.C., Gelfand, E.W. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  13. Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Umland, S.P., Shah, H., Jakway, J.P., Shortall, J., Razac, S., Garlisi, C.G., Falcone, A., Kung, T.T., Stelts, D., Hegde, V., Patel, M., Motasim Billah, M., Egan, R.W. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  14. Identification of R146225 as a novel, orally active inhibitor of interleukin-5 biosynthesis. Van Wauwe, J., Aerts, F., Cools, M., Deroose, F., Freyne, E., Goossens, J., Hermans, B., Lacrampe, J., Van Genechten, H., Van Gerven, F., Van Nyen, G. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  15. Interleukin 5 induces S mu-S gamma 1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: a three component model for Ig class switching. Mandler, R., Chu, C.C., Paul, W.E., Max, E.E., Snapper, C.M. J. Exp. Med. (1993) [Pubmed]
  16. Differential regulation of interleukin 4 and interleukin 5 gene expression: a comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines. Bohjanen, P.R., Okajima, M., Hodes, R.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  17. CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: synergistic effects with interleukin 5. Kikuchi, Y., Yasue, T., Miyake, K., Kimoto, M., Takatsu, K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  18. A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction. Takaki, S., Kanazawa, H., Shiiba, M., Takatsu, K. Mol. Cell. Biol. (1994) [Pubmed]
  19. Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells. Erard, F., Wild, M.T., Garcia-Sanz, J.A., Le Gros, G. Science (1993) [Pubmed]
  20. Eosinophilia in transgenic mice expressing interleukin 5. Dent, L.A., Strath, M., Mellor, A.L., Sanderson, C.J. J. Exp. Med. (1990) [Pubmed]
  21. Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively. Takagi, M., Hara, T., Ichihara, M., Takatsu, K., Miyajima, A. J. Exp. Med. (1995) [Pubmed]
  22. A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5. Yasue, T., Nishizumi, H., Aizawa, S., Yamamoto, T., Miyake, K., Mizoguchi, C., Uehara, S., Kikuchi, Y., Takatsu, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  23. Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression. Murray, P.D., McKenzie, D.T., Swain, S.L., Kagnoff, M.F. J. Immunol. (1987) [Pubmed]
  24. Biochemical and functional characterization of soluble form of IL-5 receptor alpha (sIL-5R alpha). Development of ELISA system for detection of sIL-5R alpha. Kikuchi, Y., Migita, M., Takaki, S., Tominaga, A., Takatsu, K. J. Immunol. Methods (1994) [Pubmed]
  25. Interleukin 2- and interleukin 5-induced changes in the binding of regulatory factors to the J-chain gene promoter. McFadden, H.J., Koshland, M.E. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  26. Expression of IL-3 receptor in testis. Morikawa, Y., Tohya, K., Hara, T., Kitamura, T., Miyajima, A. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  27. Preparation of T cell growth factor free from interferon and factors stimulating hemopoietic cells and mast cells. Clark-Lewis, I., Schrader, J.W., McKimm-Breschkin, J.L. J. Immunol. Methods (1982) [Pubmed]
  28. Major histocompatibility complex regulation of interleukin-5 production in the mouse. Dieli, F., Sireci, G., Lio, D., Bonanno, C.T., Salerno, A. Eur. J. Immunol. (1993) [Pubmed]
  29. Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE. Purkerson, J.M., Isakson, P.C. J. Exp. Med. (1992) [Pubmed]
  30. IL-5-induced hypereosinophilia suppresses the antigen-induced immune response via a TGF-beta-dependent mechanism. Nakagome, K., Dohi, M., Okunishi, K., Tanaka, R., Kouro, T., Kano, M.R., Miyazono, K., Miyazaki, J., Takatsu, K., Yamamoto, K. J. Immunol. (2007) [Pubmed]
  31. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. Grünig, G., Corry, D.B., Leach, M.W., Seymour, B.W., Kurup, V.P., Rennick, D.M. J. Exp. Med. (1997) [Pubmed]
  32. Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells. Purkerson, J.M., Newberg, M., Wise, G., Lynch, K.R., Isakson, P.C. J. Exp. Med. (1988) [Pubmed]
  33. Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor. Yamaguchi, Y., Hayashi, Y., Sugama, Y., Miura, Y., Kasahara, T., Kitamura, S., Torisu, M., Mita, S., Tominaga, A., Takatsu, K. J. Exp. Med. (1988) [Pubmed]
  34. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. Mui, A.L., Wakao, H., O'Farrell, A.M., Harada, N., Miyajima, A. EMBO J. (1995) [Pubmed]
  35. Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow. Byström, J., Wynn, T.A., Domachowske, J.B., Rosenberg, H.F. Blood (2004) [Pubmed]
  36. Biochemical characterization of regulatory factors derived from T cell hybridomas and spleen cells. I. Separation of T cell growth factor and T cell replacing factor from granulocyte-macrophage colony-stimulating factor. Clark-Lewis, I., Schrader, J.W. J. Immunol. (1982) [Pubmed]
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