Disease relevance of GEFT

• Together, our data suggest that GEFT enhances dendritic spine formation and neurite outgrowth in primary neurons and neuroblastoma cells, respectively, through the activation of Rac/Cdc42-PAK signaling pathways [1].

Psychiatry related information on GEFT

• One hundred thirty-nine male veterans receiving treatment for alcoholism were administered the Cornell Medical Index (CMI), neuropsychological tests comprising the Brain Age Quotient (BAQ) and the Group Embedded Figures Test (GEFT) [2].
• The GEFT and MMPI shared 16% common variance [3].
• As predicted, the experimental group showed greater improvement on 6 out of 10 mental health subscales (PAS) and on the GEFT than the controls [4].
• Eighty-one male alcoholics, mean age of 42.9, receiving treatment for alcoholism at the Seattle VA Medical Center were administered the GEFT, Shipley Hartford Institute of Living Scale, the Trail Making Test (TMT), and the Clinical Analysis Questionnaire (CAQ) [5].
• Multiple linear regression analyses indicated that the GEFT and CAQ shared 24% common variance; second-order CAQ factors of Depression, Independence, and Extraversion contributed significantly [3].

High impact information on GEFT

• AP-1 and NF-kappaB, two transcriptional factors involved in neurite outgrowth and survival, were up-regulated in GEFT-expressing cells [1].
• Exogenous expression of GEFT promotes dendrite outgrowth in hippocampal neurons, resulting in spines with larger size as compared with control spines [1].
• We demonstrate that a newly identified guanine nucleotide exchange factor, GEFT, is widely expressed in the brain and highly concentrated in the hippocampus, and the Purkinje and granular cells of the cerebellum [1].
• Within retinoic acid-induced neurite extensions, GEFT is localized to actin-enriched regions in the primary neurites, with little or no expression from secondary branches [6].
• Dibutyric cAMP-induced neurite extensions are highly concentrated for GEFT at the actin-rich distal tip of the growth cone [6].

Biological context of GEFT

• Fourteen pharmacists and 10 technicians in an ambulatory care pharmacy at a general medical-surgical hospital were tested for distractibility by using the group embedded figures test (GEFT) as well as for visual acuity and hearing [7].

Anatomical context of GEFT

• In line with these data, expression of either p63RhoGEF or GEFT in J82 human bladder carcinoma cells induced the formation of actin stress fibres [8].
• As judged by RT-PCR with specific primers, we were able to detect mRNA variants encoding p63RhoGEF and GEFT within several tissues and cell lines [8].

Associations of GEFT with chemical compounds

• Here we demonstrate that GEFT protein is highly expressed in all regions of the brain and is highly up-regulated upon treatment of Neuro2A cells with retinoic acid and dibutyric cAMP, which promote dendrite and axon-like neurite extensions, respectively [6].

Other interactions of GEFT

• Recently, an N-terminally truncated form of p63RhoGEF, termed GEFT, was described as a Rac/Cdc42-specific GEF (Guo et al. 2003) [8].
• We therefore conclude that p63RhoGEF and GEFT are apparently isoforms derived from the same gene and that GEFT, similar to p63RhoGEF, activates RhoA in several cell types [8].

Analytical, diagnostic and therapeutic context of GEFT

• No relation was found between the GEFT and the indirect vision test [9].

References