Gene Review:
ARHGEF2 - Rho/Rac guanine nucleotide exchange factor...
Homo sapiens
Synonyms:
GEF, GEF-H1, GEFH1, Guanine nucleotide exchange factor H1, KIAA0651, ...
- Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Fernandez-Zapico, M.E., Gonzalez-Paz, N.C., Weiss, E., Savoy, D.N., Molina, J.R., Fonseca, R., Smyrk, T.C., Chari, S.T., Urrutia, R., Billadeau, D.D. Cancer Cell (2005)
- Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease. Yamanaka, K., Vande Velde, C., Eymard-Pierre, E., Bertini, E., Boespflug-Tanguy, O., Cleveland, D.W. Proc. Natl. Acad. Sci. U.S.A. (2003)
- A yeast genetic system for the identification and characterization of substrate proteins transferred into host cells by the Legionella pneumophila Dot/Icm system. Campodonico, E.M., Chesnel, L., Roy, C.R. Mol. Microbiol. (2005)
- Vav3, a Rho GTPase Guanine Nucleotide Exchange Factor, Increases during Progression to Androgen Independence in Prostate Cancer Cells and Potentiates Androgen Receptor Transcriptional Activity. Lyons, L.S., Burnstein, K.L. Mol. Endocrinol. (2006)
- Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection. Huang, F.C., Werne, A., Li, Q., Galyov, E.E., Walker, W.A., Cherayil, B.J. Infect. Immun. (2004)
- Neonatal neurosteroid administration results in development-specific alterations in prepulse inhibition and locomotor activity: neurosteroids alter prepulse inhibition and locomotor activity. Gizerian, S.S., Moy, S.S., Lieberman, J.A., Grobin, A.C. Psychopharmacology (Berl.) (2006)
- Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Somlyo, A.P., Somlyo, A.V. Physiol. Rev. (2003)
- Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. Delprato, A., Merithew, E., Lambright, D.G. Cell (2004)
- Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Renault, L., Kuhlmann, J., Henkel, A., Wittinghofer, A. Cell (2001)
- A posttermination ribosomal complex is the guanine nucleotide exchange factor for peptide release factor RF3. Zavialov, A.V., Buckingham, R.H., Ehrenberg, M. Cell (2001)
- Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Krendel, M., Zenke, F.T., Bokoch, G.M. Nat. Cell Biol. (2002)
- Isolation and characterization of complementary DNA to proliferating cell nucleolar antigen P40. Reddy, A.B., Chatterjee, A., Rothblum, L.I., Black, A., Busch, H. Cancer Res. (1989)
- p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. Zenke, F.T., Krendel, M., DerMardirossian, C., King, C.C., Bohl, B.P., Bokoch, G.M. J. Biol. Chem. (2004)
- Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Ren, Y., Li, R., Zheng, Y., Busch, H. J. Biol. Chem. (1998)
- Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission. Chalamalasetty, R.B., Hümmer, S., Nigg, E.A., Silljé, H.H. J. Cell. Sci. (2006)
- The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity. Billadeau, D.D., Mackie, S.M., Schoon, R.A., Leibson, P.J. J. Exp. Med. (2000)
- The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Tolias, K.F., Bikoff, J.B., Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R.J., Greenberg, M.E. Neuron (2005)
- Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Penzes, P., Beeser, A., Chernoff, J., Schiller, M.R., Eipper, B.A., Mains, R.E., Huganir, R.L. Neuron (2003)
- Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Gao, Y., Dickerson, J.B., Guo, F., Zheng, J., Zheng, Y. Proc. Natl. Acad. Sci. U.S.A. (2004)
- TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. Kamon, H., Kawabe, T., Kitamura, H., Lee, J., Kamimura, D., Kaisho, T., Akira, S., Iwamatsu, A., Koga, H., Murakami, M., Hirano, T. EMBO J. (2006)
- A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Kawasaki, H., Springett, G.M., Toki, S., Canales, J.J., Harlan, P., Blumenstiel, J.P., Chen, E.J., Bany, I.A., Mochizuki, N., Ashbacher, A., Matsuda, M., Housman, D.E., Graybiel, A.M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins. Zhang, B., Zhang, Y., Wang, Z., Zheng, Y. J. Biol. Chem. (2000)
- GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Birkenfeld, J., Nalbant, P., Bohl, B.P., Pertz, O., Hahn, K.M., Bokoch, G.M. Dev. Cell (2007)
- Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. Kiyono, M., Kato, J., Kataoka, T., Kaziro, Y., Satoh, T. J. Biol. Chem. (2000)
- The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Santy, L.C., Ravichandran, K.S., Casanova, J.E. Curr. Biol. (2005)
- Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. Aijaz, S., D'Atri, F., Citi, S., Balda, M.S., Matter, K. Dev. Cell (2005)
- Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. Diviani, D., Abuin, L., Cotecchia, S., Pansier, L. EMBO J. (2004)
- Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. Price, M.O., Atkinson, S.J., Knaus, U.G., Dinauer, M.C. J. Biol. Chem. (2002)
- Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. de Rooij, J., Rehmann, H., van Triest, M., Cool, R.H., Wittinghofer, A., Bos, J.L. J. Biol. Chem. (2000)
- RGS16 inhibits signalling through the G alpha 13-Rho axis. Johnson, E.N., Seasholtz, T.M., Waheed, A.A., Kreutz, B., Suzuki, N., Kozasa, T., Jones, T.L., Brown, J.H., Druey, K.M. Nat. Cell Biol. (2003)
- An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential. Yoshizuka, N., Moriuchi, R., Mori, T., Yamada, K., Hasegawa, S., Maeda, T., Shimada, T., Yamada, Y., Kamihira, S., Tomonaga, M., Katamine, S. J. Biol. Chem. (2004)
- Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. Rebhun, J.F., Castro, A.F., Quilliam, L.A. J. Biol. Chem. (2000)
- The tail domain of myosin M catalyses nucleotide exchange on Rac1 GTPases and can induce actin-driven surface protrusions. Geissler, H., Ullmann, R., Soldati, T. Traffic (2000)
- Identification of a plasma membrane-associated guanine nucleotide exchange factor for ARF6 in chromaffin cells. Possible role in the regulated exocytotic pathway. Caumont, A.S., Vitale, N., Gensse, M., Galas, M.C., Casanova, J.E., Bader, M.F. J. Biol. Chem. (2000)
- The value of the QRS scoring system in assessing regional and global left ventricular ejection fraction early after myocardial infarction. Bergovec, M., Prpìć, H., Mihatov, S., Zigman, M., Vukosavić, D., Birtić, K., Franceschi, D., Barić, L. Eur. Heart J. (1993)
- Effect of photoreceptor degeneration on RNA splicing and expression of AMPA receptors. Namekata, K., Okumura, A., Harada, C., Nakamura, K., Yoshida, H., Harada, T. Mol. Vis. (2006)