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Gene Review

CAPN5  -  calpain 5

Homo sapiens

Synonyms: ADNIV, Calpain htra-3, Calpain-5, HTRA3, NCL3, ...
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Disease relevance of CAPN5


High impact information on CAPN5


Biological context of CAPN5


Anatomical context of CAPN5


Other interactions of CAPN5


Analytical, diagnostic and therapeutic context of CAPN5

  • RT-PCR analysis revealed strong expression of calpain-5 in rat lungs, kidneys, and brain while week expression in heart, whereas in rat brain regions it is ubiquitously expressed [2].
  • Molecular cloning and characterization of rat and human calpain-5 [2].


  1. Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome. González, A., Sáez, M.E., Aragón, M.J., Galán, J.J., Vettori, P., Molina, L., Rubio, C., Real, L.M., Ruiz, A., Ramírez-Lorca, R. Hum. Reprod. (2006) [Pubmed]
  2. Molecular cloning and characterization of rat and human calpain-5. Waghray, A., Wang, D.S., McKinsey, D., Hayes, R.L., Wang, K.K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  3. Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily. Matena, K., Boehm, T., Dear, N. Genomics (1998) [Pubmed]
  4. Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels. Sáez, M.E., Martínez-Larrad, M.T., Ramírez-Lorca, R., González-Sánchez, J.L., Zabena, C., Martinez-Calatrava, M.J., González, A., Morón, F.J., Ruiz, A., Serrano-Ríos, M. BMC Med. Genet. (2007) [Pubmed]
  5. Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene. Mugita, N., Kimura, Y., Ogawa, M., Saya, H., Nakao, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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