Disease relevance of Cdh8

• Expression of cadherin-8 in renal cell carcinoma and fetal kidney [1].

High impact information on Cdh8

• We show that during their migration, fbm neurones regulate the expression of genes encoding the cell membrane proteins TAG-1, Ret and cadherin 8 [2].
• In particular, cadherin-8 may be involved in both kidney morphogenesis as well as tumorigenesis in some types of RCC [1].
• Interestingly, cadherin-8, previously shown in mice to be restricted to the CNS and thymus during development, was detected by RT-PCR, immunofluorescence and in situ hybridization in 4 of 16 RCC cell lines as well as in paraffin sections of the corresponding human RCC biopsies [1].
• Likewise, in the inner nuclear layer, R-cadherin and cadherin-6 and -8 were expressed by a restricted population of amacrine cells, and cadherin-8 also by a subpopulation of bipolar cells [3].
• Comparison with the expression of Cadherin 8, a marker of the developing dorsolateral claustrum, indicates that the core includes a central part of the dorsolateral claustrum, whereas the shell includes a peripheral area of the dorsolateral claustrum, plus the adjacent ventromedial claustrum [4].

Biological context of Cdh8

• The deduced amino acid sequence of the mature form of mCad8 shows 98.2% identity with the sequence of human cadherin-8 [5].
• In contrast, during embryonic development the dorsolateral claustrum, the basolateral amygdalar nucleus, and the posterolateral cortical amygdalar area do not express or show weak expression of Neurogenin 2 or Semaphorin 5A, but express selectively and strongly Cadherin 8 plus Emx1, and may be derivatives of the lateral pallium [6].

Anatomical context of Cdh8

• These findings suggest that cadherin-8 is involved in the formation of particular neural circuits by connecting areas expressing this molecule with positive nerve fibers, and indicate its possible implication in subdivisional organization in the superior colliculus and cerebellum [7].
• Expression of cadherin-8 mRNA in the developing mouse central nervous system [8].
• Cadherin-8 protein expression in gray matter structures and nerve fibers of the neonatal and adult mouse brain [7].
• Cadherin-8 expression was restricted to several areas in neonatal brains constituting particular neural circuits, i.e. the limbic system, the basal ganglia-thalamocortical circuit, and the cerebellum and related nuclei [7].
• In the hindbrain, cadherin-8 is expressed by several cranial nerve nuclei [8].

Associations of Cdh8 with chemical compounds

• Menthol selectively increased the frequency of the slow mEPSCs in cad8+/- slices, but this effect was abolished in cad8-/- slices [9].

Other interactions of Cdh8

• Cadherin-8 expression also showed a patch-like distribution in the intermediate gray layer of the superior colliculus, resembling acetylcholinesterase-rich patches in allocation [7].
• The cerebellum itself shows parasagittal stripes of cadherin-8 expression in the Purkinje cell layer [8].
• For example, members of the cadherin family of adhesion molecules (cadherin-8 and OL-protocadherin) are differentially expressed by the striosomes and the striatal matrix [10].

References