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Gene Review

Cdh8  -  cadherin 8

Mus musculus

Synonyms: AI851472, Cadherin-8, cad8
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Disease relevance of Cdh8


High impact information on Cdh8


Biological context of Cdh8

  • The deduced amino acid sequence of the mature form of mCad8 shows 98.2% identity with the sequence of human cadherin-8 [5].
  • In contrast, during embryonic development the dorsolateral claustrum, the basolateral amygdalar nucleus, and the posterolateral cortical amygdalar area do not express or show weak expression of Neurogenin 2 or Semaphorin 5A, but express selectively and strongly Cadherin 8 plus Emx1, and may be derivatives of the lateral pallium [6].

Anatomical context of Cdh8


Associations of Cdh8 with chemical compounds

  • Menthol selectively increased the frequency of the slow mEPSCs in cad8+/- slices, but this effect was abolished in cad8-/- slices [9].

Other interactions of Cdh8


  1. Expression of cadherin-8 in renal cell carcinoma and fetal kidney. Blaschke, S., Mueller, C.A., Markovic-Lipkovski, J., Puch, S., Miosge, N., Becker, V., Mueller, G.A., Klein, G. Int. J. Cancer (2002) [Pubmed]
  2. Control of the migratory pathway of facial branchiomotor neurones. Garel, S., Garcia-Dominguez, M., Charnay, P. Development (2000) [Pubmed]
  3. Differential expression of cadherin adhesion receptors in neural retina of the postnatal mouse. Honjo, M., Tanihara, H., Suzuki, S., Tanaka, T., Honda, Y., Takeichi, M. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  4. Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex. Dávila, J.C., Real, M.A., Olmos, L., Legaz, I., Medina, L., Guirado, S. J. Comp. Neurol. (2005) [Pubmed]
  5. Restricted expression of cadherin-8 in segmental and functional subdivisions of the embryonic mouse brain. Korematsu, K., Redies, C. Dev. Dyn. (1997) [Pubmed]
  6. Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex. Medina, L., Legaz, I., González, G., De Castro, F., Rubenstein, J.L., Puelles, L. J. Comp. Neurol. (2004) [Pubmed]
  7. Cadherin-8 protein expression in gray matter structures and nerve fibers of the neonatal and adult mouse brain. Korematsu, K., Nishi, T., Okamura, A., Goto, S., Morioka, M., Hamada, J., Ushio, Y. Neuroscience (1998) [Pubmed]
  8. Expression of cadherin-8 mRNA in the developing mouse central nervous system. Korematsu, K., Redies, C. J. Comp. Neurol. (1997) [Pubmed]
  9. Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. Suzuki, S.C., Furue, H., Koga, K., Jiang, N., Nohmi, M., Shimazaki, Y., Katoh-Fukui, Y., Yokoyama, M., Yoshimura, M., Takeichi, M. J. Neurosci. (2007) [Pubmed]
  10. Patch/matrix patterns of gray matter differentiation in the telencephalon of chicken and mouse. Redies, C., Kovjanic, D., Heyers, D., Medina, L., Hirano, S., Suzuki, S.T., Puelles, L. Brain Res. Bull. (2002) [Pubmed]
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