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Gene Review

VPS39  -  vacuolar protein sorting 39 homolog (S....

Homo sapiens

Synonyms: KIAA0770, TLP, TRAP1-like protein, VAM6, Vam6/Vps39-like protein, ...
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Disease relevance of VPS39

  • A new human tumor-associated antigen (TLP) is naturally expressed in rat DHD-K12 colorectal tumor cells [1].
  • This is in agreement with our previous studies, in which we had demonstrated that TLP is expressed in human colorectal cancer and adenomas but not in normal colonic mucosa [1].
  • In order to develop an experimental model suitable for preclinical studies on cancer vaccines, we investigated the presence of TLP antigen in vitro, in the DHD-K12 cell line and in vivo, in metastases induced in syngeneic BDIX rats by DHD-K12 cell injection [1].
  • The total blood lymphocyte proliferation assay (TLP) was evaluated as a screening test for infection with Mycobacterium tuberculosis and was compared with the tuberculin (Mantoux) skin test [2].
  • We demonstrated that TLP genes are expressed in a bacterium (E. coli), an invertebrate animal (C. elegans), and a plant (A. thaliana) [3].

High impact information on VPS39

  • Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo [4].
  • Overexpression of hVam6p results in massive clustering and fusion of lysosomes and late endosomes into large (2-3 microm) juxtanuclear structures [4].
  • Using protein-free modified Tyrode's medium (TLP-PVA) containing 10 mM lactate (L), 0.1 mM pyruvate (P), and amino acids (Phe, Ile, Met and Gln), we found that development of hamster 8-cell embryos to blastocysts was supported better in the absence of glucose than in medium containing (standard) 5 mM glucose (88.1% and 50%, respectively) [5].
  • The culture medium used throughout incubation was a modified Tyrode's solution containing 10 mM sodium lactate, 100 microM sodium pyruvate and 1.0 mg/ml polyvinylalcohol (TLP-PVA) [6].
  • The influence of sodium dihydrogen phosphate (Pi) and glucose on the development of hamster 8-cell embryos mediated by pyruvate (P) or amino acids (A) or lactate (L) was investigated using modified Tyrode's medium, TLP-PVA [7].

Anatomical context of VPS39


Associations of VPS39 with chemical compounds

  • CONCLUSION: In a large portion of patients eligible for TL or TLPP the larynx was preserved by paclitaxel/cisplatin ICHT and 3D RT [8].
  • There was a high correlation between skin test responses and TLP responses to PPD which was statistically significant [2].
  • The experimental preincubation medium was TLP-PVA with additional D-penicillamine (125 or 500 microM), or L-histidine (10, 100, or 1,000 microM) or L-cysteine (25, 75, or 125 microM) [11].

Physical interactions of VPS39

  • We describe the cloning and identification of a rice cDNA, OsTVLP1, encoding a protein with similarity to TGF-beta receptor interacting proteins and vacuolar assembly Vam6p/Vps39p proteins [12].

Analytical, diagnostic and therapeutic context of VPS39

  • The results of TLP assays performed on 33 patients with tuberculosis and 37 non-tuberculous subjects were compared with results of skin tests performed in the previous year [2].
  • Significant decreases in numbers of salivary anaerobic bacterial CFUs, and NA and TLP levels were observed in the professional oral care group compared to that in the control group (p<0.01) [13].
  • Results are discussed in terms of needed research examining the mechanism of stress intruders' susceptibility to stress-induced immunosuppression and the possible clinical significance of brief periods of stress-induced decrements in TLPP levels [9].
  • Nine of 15 patients with TLPP (two patients with primary closure, three with free forearm flap, and four with free jejunal flap) were examined for voice restoration and fluoroscopy of the neopharynx [10].
  • It is implemented in ECG instruments, using the Gotemba microdot thermal printers TLP 480Z and TLP 880Z produced in Japan [14].


  1. A new human tumor-associated antigen (TLP) is naturally expressed in rat DHD-K12 colorectal tumor cells. Rasi, G., Sinibaldi-Vallebona, P., Serafino, A., Bernard, P., Pierimarchi, P., Guarino, E., Faticanti-Scucchi, L., Graziano, P., Guadagni, F., Garci, E. Int. J. Cancer (2000) [Pubmed]
  2. Appraisal of the total blood lymphocyte proliferation assay as a diagnostic tool in screening for tuberculosis. Fiavey, N.P., Frankenburg, S. J. Med. Microbiol. (1992) [Pubmed]
  3. Structural and functional evolution of transthyretin and transthyretin-like proteins. Hennebry, S.C., Wright, H.M., Likic, V.A., Richardson, S.J. Proteins (2006) [Pubmed]
  4. Human Vam6p promotes lysosome clustering and fusion in vivo. Caplan, S., Hartnell, L.M., Aguilar, R.C., Naslavsky, N., Bonifacino, J.S. J. Cell Biol. (2001) [Pubmed]
  5. Glucose inhibits development of hamster 8-cell embryos in vitro. Seshagiri, P.B., Bavister, B.D. Biol. Reprod. (1989) [Pubmed]
  6. Hamster zonae pellucidae cannot induce physiological acrosome reactions in chemically capacitated hamster spermatozoa in the absence of albumin. Andrews, J.C., Bavister, B.D. Biol. Reprod. (1989) [Pubmed]
  7. Phosphate is required for inhibition by glucose of development of hamster 8-cell embryos in vitro. Seshagiri, P.B., Bavister, B.D. Biol. Reprod. (1989) [Pubmed]
  8. Induction chemotherapy with paclitaxel and cisplatin and CT-based 3D radiotherapy in patients with advanced laryngeal and hypopharyngeal carcinomas--a possibility for organ preservation. Pfreundner, L., Hoppe, F., Willner, J., Preisler, V., Bratengeier, K., Hagen, R., Helms, J., Flentje, M. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2003) [Pubmed]
  9. T-lymphocyte polyclonal proliferation: effects of stress and stress response style on medical students taking national board examinations. Workman, E.A., La Via, M.F. Clin. Immunol. Immunopathol. (1987) [Pubmed]
  10. Neoglottic formation from posterior pharyngeal wall conserved in surgery for hypopharyngeal cancer. Iwai, H., Tsuji, H., Tachikawa, T., Inoue, T., Izumikawa, M., Yamamichi, K., Yamashita, T. Auris, nasus, larynx. (2002) [Pubmed]
  11. Capacitation of hamster spermatozoa with the divalent cation chelators D-penicillamine, L-histidine, and L-cysteine in a protein-free culture medium. Andrews, J.C., Bavister, B.D. Gamete research. (1989) [Pubmed]
  12. Molecular cloning and expression analysis of rice OsTVLP1, encoding a protein with similarity to TGF-beta receptor interacting proteins and vacuolar assembly Vam6p/Vps39p proteins. Hu, X., Song, F., Zheng, Z. DNA Seq. (2006) [Pubmed]
  13. Professional oral care reduces influenza infection in elderly. Abe, S., Ishihara, K., Adachi, M., Sasaki, H., Tanaka, K., Okuda, K. Archives of gerontology and geriatrics. (2006) [Pubmed]
  14. Recording vectorcardiographic loops with a microdot thermal printer. Christov, I.I., Dotsinsky, I.A. Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering. (1990) [Pubmed]
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