The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

cpdm  -  chronic proliferative dermatitis

Mus musculus

This record was replaced with 106025.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cpdm


High impact information on cpdm

  • The cpdm mutation causes a complex phenotype that is characterized by multiorgan inflammation and the defective development of lymphoid tissues [2].
  • The cpdm/cpdm mouse may be a useful model to study the factors that control the development of lymphoid tissues, in particular the Peyer's patches, and the mechanisms that control the humoral immune response [2].
  • Furthermore, the cpdm/cpdm mouse can be used to study chronic inflammatory skin disease because of the severe epidermal proliferation [6].
  • Compared with control animals, 6-week-old cpdm/cpdm mice had decreased serum IgE levels and increased numbers of mast cells [6].
  • Although various pathogenetic aspects of the cpdm/cpdm mouse need further elucidation, this model can be a tool to study eosinophil infiltration, leukocyte-endothelial cell interactions, and mast cell proliferation [6].

Chemical compound and disease context of cpdm


Anatomical context of cpdm


Associations of cpdm with chemical compounds

  • An increased number of proliferating keratinocytes was present in the cpdm/cpdm skin-graft transplanted to nudes or to C57BL/Ka mice based on short-term bromodeoxyuridine labeling [8].
  • Treatment of the cpdm/cpdm mice with calcipotriene (5 microg/day for 3 weeks) inhibited epidermal proliferation and the number of eosinophils [10].
  • The correlation between visual and automatic quantification of spontaneous cpdm mouse scratching was 81.7+/-2.5% (mean +/- S.E.M.). For histamine, the correlation was 85.6+/-3.6% (mean +/- S.E.M.) and for Compound 48/80, 85.8+/-3.1% (mean +/- S.E.M.). The PDS routinely detected less than 5% false-positive signals [7].

Other interactions of cpdm


Analytical, diagnostic and therapeutic context of cpdm


  1. Changes in keratin and filaggrin expression in the skin of chronic proliferative dermatitis (cpdm) mutant mice. HogenEsch, H., Boggess, D., Sundberg, J.P. Pathobiology (1999) [Pubmed]
  2. Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice. HogenEsch, H., Janke, S., Boggess, D., Sundberg, J.P. J. Immunol. (1999) [Pubmed]
  3. Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with IL-12. HogenEsch, H., Torregrosa, S.E., Boggess, D., Sundberg, B.A., Carroll, J., Sundberg, J.P. Eur. J. Immunol. (2001) [Pubmed]
  4. Increased expression of chemokines in the skin of chronic proliferative dermatitis mutant mice. Renninger, M.L., Seymour, R., Lillard, J.W., Sundberg, J.P., HogenEsch, H. Exp. Dermatol. (2005) [Pubmed]
  5. Ultrastructure of epidermis of mice with chronic proliferative dermatitis. Gijbels, M.J., HogenEsch, H., Blauw, B., Roholl, P., Zurcher, C. Ultrastructural pathology. (1995) [Pubmed]
  6. Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm). Gijbels, M.J., Zurcher, C., Kraal, G., Elliott, G.R., HogenEsch, H., Schijff, G., Savelkoul, H.F., Bruijnzeel, P.L. Am. J. Pathol. (1996) [Pubmed]
  7. An automated method for registering and quantifying scratching activity in mice: use for drug evaluation. Elliott, G.R., Vanwersch, R.A., Bruijnzeel, P.L. Journal of pharmacological and toxicological methods. (2000) [Pubmed]
  8. Maintenance of donor phenotype after full-thickness skin transplantation from mice with chronic proliferative dermatitis (cpdm/cpdm) to C57BL/Ka and nude mice and vice versa. Gijbels, M.J., HogenEsch, H., Bruijnzeel, P.L., Elliott, G.R., Zurcher, C. J. Invest. Dermatol. (1995) [Pubmed]
  9. Chronic proliferative dermatitis in mice: neutrophil-endothelium interactions and the role of adhesion molecules. Gallardo Torres, H.I., Gijbels, M.J., HegnEsch, H., Kraal, G. Pathobiology (1995) [Pubmed]
  10. Therapeutic interventions in mice with chronic proliferative dermatitis (cpdm/cpdm). Gijbels, M.J., Elliott, G.R., HogenEsch, H., Zurcher, C., van den Hoven, A., Bruijnzeel, P.L. Exp. Dermatol. (2000) [Pubmed]
  11. Animal models of psoriasis - what can we learn from them? Schön, M.P. J. Invest. Dermatol. (1999) [Pubmed]
  12. Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice. Hogenesch, H., Dunham, A., Seymour, R., Renninger, M., Sundberg, J.P. Exp. Dermatol. (2006) [Pubmed]
WikiGenes - Universities