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Gene Review

Cux2  -  cut-like homeobox 2

Mus musculus

Synonyms: 1700051K22Rik, Cutl2, Cux-2, ENSMUSG00000072641, Homeobox protein Cux-2, ...
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Disease relevance of Cutl2


High impact information on Cutl2


Biological context of Cutl2

  • More recently, vertebrates were found to possess a second cut orthologs that was generated by gene duplication: Cux2 [1].
  • Here we describe the dynamic profile of Cux2 during mouse embryogenesis [3].
  • Cux2 is hypothesized to function as a transcriptional regulator that inhibits terminal differentiation and cell cycle exit [3].
  • Cux2 expression coincides with many tissue regions undergoing proliferative growth or cell rearrangements, however some later expression domains also include sites of programmed cell death [3].

Anatomical context of Cutl2


Associations of Cutl2 with chemical compounds

  • Cux-2 mRNA expression is also found in the embryonic SVZ, overlapping with BrdU-positive dividing precursors, but it is not expressed in the VZ [4].

Physical interactions of Cutl2


Other interactions of Cutl2

  • We did not observe an N-terminally processed Cux2 isoform equivalent to the Cux1 p110 isoform [1].
  • Using different molecular markers and Pax6-deficient mice, we provide data that suggest a relationship between the early-determined Cux2-positive neuronal precursors in the SVZ/IZ and upper layer neurons [7].
  • Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia [3].
  • Our findings suggest that Cux2 might mediate some of the effects of Notch signaling on interneuron formation [8].


  1. Biochemical characterization of the mammalian Cux2 protein. Gingras, H., Cases, O., Krasilnikova, M., Bérubé, G., Nepveu, A. Gene (2005) [Pubmed]
  2. Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut. Quaggin, S.E., Heuvel, G.B., Golden, K., Bodmer, R., Igarashi, P. J. Biol. Chem. (1996) [Pubmed]
  3. Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia. Iulianella, A., Vanden Heuvel, G., Trainor, P. Gene Expr. Patterns (2003) [Pubmed]
  4. Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex. Nieto, M., Monuki, E.S., Tang, H., Imitola, J., Haubst, N., Khoury, S.J., Cunningham, J., Gotz, M., Walsh, C.A. J. Comp. Neurol. (2004) [Pubmed]
  5. Expression of Cux-1 and Cux-2 in the developing somatosensory cortex of normal and barrel-defective mice. Ferrere, A., Vitalis, T., Gingras, H., Gaspar, P., Cases, O. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2006) [Pubmed]
  6. Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis. Iulianella, A., Sharma, M., Durnin, M., Vanden Heuvel, G.B., Trainor, P.A. Development (2008) [Pubmed]
  7. Dynamics of Cux2 expression suggests that an early pool of SVZ precursors is fated to become upper cortical layer neurons. Zimmer, C., Tiveron, M.C., Bodmer, R., Cremer, H. Cereb. Cortex (2004) [Pubmed]
  8. Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord. Iulianella, A., Sharma, M., Vanden Heuvel, G.B., Trainor, P.A. Development (2009) [Pubmed]
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