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MeSH Review

Glossopharyngeal Nerve

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Disease relevance of Glossopharyngeal Nerve


High impact information on Glossopharyngeal Nerve

  • Whole-cell patch-clamp recordings of activities of taste receptor cells isolated from circumvallate papillae (innervated by the glossopharyngeal nerve) demonstrated that leptin activated outward K(+) currents, which resulted in hyperpolarization of taste cells [2].
  • In addition, the vagal and glossopharyngeal nerves appeared abnormal in approximately 50% of mutant embryos, which may be related to the observed reduction of Phox2b expression in the nucleus ambiguus of adult mutant mice [3].
  • R-cadherin is not expressed by sensory fibers, but is expressed by the visceral motor system of the vagus and glossopharyngeal nerves, which are N-cadherin negative [4].
  • We also recorded the neural activity from the glossopharyngeal nerve during stimulation with thaumatin, sucrose, citric acid, and NaCl [5].
  • Finally, we studied the role of sensory projections to the CNS by examining petrosal TH after glossopharyngeal nerve rhizotomy [6].

Anatomical context of Glossopharyngeal Nerve


Associations of Glossopharyngeal Nerve with chemical compounds


Gene context of Glossopharyngeal Nerve

  • Using an immunocytochemical method, we examined the expression of BDNF and its receptor, TrkB, in the taste bud cells of the circumvallate papillae of normal mice and of mice after transection of the glossopharyngeal nerves [17].
  • Hoxa3 regulates integration of glossopharyngeal nerve precursor cells [18].
  • After bisection of the glossopharyngeal nerves, NeuroD-expressing cells decreased in number at day 4 and disappeared from the trench wall of the circumvallate papillae by day 14 [19].
  • The distribution of calbindin D28k (CB)-like immunoreactivity (-LI) in the circumvallate papilla (CVP) was examined during development and regeneration following bilateral crush injury to the glossopharyngeal nerve in the rat [20].
  • The otic and optic vesicles were also strongly GH immunoreactive, as were the Vth (semi-lunar), VIIth (facial), VIIIth (acoustic) and IXth (glossopharyngeal) nerve ganglia [21].

Analytical, diagnostic and therapeutic context of Glossopharyngeal Nerve


  1. Aspiration and infection in the elderly : epidemiology, diagnosis and management. Kikawada, M., Iwamoto, T., Takasaki, M. Drugs & aging. (2005) [Pubmed]
  2. Leptin as a modulator of sweet taste sensitivities in mice. Kawai, K., Sugimoto, K., Nakashima, K., Miura, H., Ninomiya, Y. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve. Pabst, O., Rummelies, J., Winter, B., Arnold, H.H. Development (2003) [Pubmed]
  4. Restricted expression of N- and R-cadherin on neurites of the developing chicken CNS. Redies, C., Inuzuka, H., Takeichi, M. J. Neurosci. (1992) [Pubmed]
  5. Evidence for a novel mechanism of binding and release of stimuli in the primate taste bud. Farbman, A.I., Hellekant, G. J. Neurosci. (1989) [Pubmed]
  6. Expression and regulation of catecholaminergic traits in primary sensory neurons: relationship to target innervation in vivo. Katz, D.M., Black, I.B. J. Neurosci. (1986) [Pubmed]
  7. Effects of gustatory deafferentation on Polycose and sucrose appetite in the rat. Vigorito, M., Sclafani, A., Jacquin, M.F. Neuroscience and biobehavioral reviews. (1987) [Pubmed]
  8. Nature and origin of cerebrovascular nerves with substance P immunoreactivity in bats (Mammalia: Microchiroptera), with special reference to species differences. Ando, K., Ishikawa, A., Okura, N. J. Comp. Neurol. (1994) [Pubmed]
  9. The microsurgical anatomy of the jugular foramen. Ayeni, S.A., Ohata, K., Tanaka, K., Hakuba, A. J. Neurosurg. (1995) [Pubmed]
  10. Cardio-ventilatory control in rainbow trout: I. Pharmacology of branchial, oxygen-sensitive chemoreceptors. Burleson, M.L., Milsom, W.K. Respiration physiology. (1995) [Pubmed]
  11. Selective excitation of parasympathetic nerve fibers to elicit the vasodilatation in cat lip. Izumi, H., Karita, K. J. Auton. Nerv. Syst. (1992) [Pubmed]
  12. A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance. Campanucci, V.A., Fearon, I.M., Nurse, C.A. J. Physiol. (Lond.) (2003) [Pubmed]
  13. Specificity of mono- and divalent salt transduction mechanisms in frog gustation evidenced by cobalt chloride treatment. Herness, M.S. J. Neurophysiol. (1991) [Pubmed]
  14. Effects of glossopharyngeal nerve transection on central and peripheral cytokines and serum corticosterone induced by localized inflammation. Romeo, H.E., Tio, D.L., Taylor, A.N. J. Neuroimmunol. (2003) [Pubmed]
  15. Cranial and cervical nerve injuries after repeat carotid endarterectomy. AbuRahma, A.F., Choueiri, M.A. J. Vasc. Surg. (2000) [Pubmed]
  16. Capsaicin induces cystatin S-like substances in submandibular saliva of the rat. Katsukawa, H., Ninomiya, Y. J. Dent. Res. (1999) [Pubmed]
  17. Expression of BDNF and TrkB in mouse taste buds after denervation and in circumvallate papillae during development. Uchida, N., Kanazawa, M., Suzuki, Y., Takeda, M. Arch. Histol. Cytol. (2003) [Pubmed]
  18. Hoxa3 regulates integration of glossopharyngeal nerve precursor cells. Watari, N., Kameda, Y., Takeichi, M., Chisaka, O. Dev. Biol. (2001) [Pubmed]
  19. Expression of NeuroD in the mouse taste buds. Suzuki, Y., Takeda, M., Obara, N. Cell Tissue Res. (2002) [Pubmed]
  20. Calbindin D28k-like immunoreactivity in the developing and regenerating circumvallate papilla of the rat. Miyawaki, Y., Morisaki, I., Tabata, M.J., Maeda, T., Kurisu, K., Wakisaka, S. Cell Tissue Res. (1998) [Pubmed]
  21. Growth hormone in neural tissues of the chick embryo. Harvey, S., Johnson, C.D., Sanders, E.J. J. Endocrinol. (2001) [Pubmed]
  22. The effect of glossopharyngeal nerve block on pain after elective adult tonsillectomy and uvulopalatoplasty. Bell, K.R., Cyna, A.M., Lawler, K.M., Sinclair, C., Kelly, P.J., Millar, F., Flood, L.M. Anaesthesia. (1997) [Pubmed]
  23. Rostral ventrolateral medulla catechol involvement upon sino-aortic deafferentation: an in vivo voltammetric study. Rentero, N., Bruandet, N., Quintin, L. Life Sci. (2000) [Pubmed]
  24. Behavioral discrimination between glutamate and the four basic taste substances in mice. Ninomiya, Y., Funakoshi, M. Comparative biochemistry and physiology. A, Comparative physiology. (1989) [Pubmed]
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