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Gene Review

Cyp2c29  -  cytochrome P450, family 2, subfamily c,...

Mus musculus

Synonyms: AHOH, AHOHase, AI159681, AI196010, Ah-2, ...
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High impact information on Cyp2c29


Biological context of Cyp2c29


Anatomical context of Cyp2c29


Associations of Cyp2c29 with chemical compounds

  • Immunoinhibition studies with epitope specific monoclonal antibodies were consistent with the major involvement of phenobarbitone- and steroid-inducible products of the Cyp2b and Cyp2c subfamilies [7].
  • Hepatic CYP2C29 mRNA was induced by phenytoin in wild-type but not in CAR-null mice, indicating that constitutive active or androstane receptor (CAR) regulates phenytoin-induced transcription of the Cyp2c29 gene [2].
  • Cyp2c29-dependent 6-demethylation of scoparone resulted in the formation of isoscopoletin, an intermediate which is susceptible to further oxidation [9].
  • Analysis of NH2-terminal sequence suggests that the isozyme is a member of the P450 2C gene subfamily [5].
  • Effects of LPS administration on mouse hepatic P450 proteins (probed using rat P450 2C, 3A, 4A, and 2E antibodies) were consistent with mRNA results in most cases [10].

Other interactions of Cyp2c29


Analytical, diagnostic and therapeutic context of Cyp2c29

  • Immunoprecipitation of microsomal protein with antibodies raised against either P450 2C or 3A revealed that approximately equal amounts of [14C]-CBD were bound to each of these P450s after CBD-mediated inactivation [12].


  1. In silico pharmacogenetics of warfarin metabolism. Guo, Y., Weller, P., Farrell, E., Cheung, P., Fitch, B., Clark, D., Wu, S.Y., Wang, J., Liao, G., Zhang, Z., Allard, J., Cheng, J., Nguyen, A., Jiang, S., Shafer, S., Usuka, J., Masjedizadeh, M., Peltz, G. Nat. Biotechnol. (2006) [Pubmed]
  2. The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29. Jackson, J.P., Ferguson, S.S., Moore, R., Negishi, M., Goldstein, J.A. Mol. Pharmacol. (2004) [Pubmed]
  3. Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities. Wang, H., Zhao, Y., Bradbury, J.A., Graves, J.P., Foley, J., Blaisdell, J.A., Goldstein, J.A., Zeldin, D.C. Mol. Pharmacol. (2004) [Pubmed]
  4. cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase. Matsunaga, T., Watanabe, K., Yamamoto, I., Negishi, M., Gonzalez, F.J., Yoshimura, H. Biochim. Biophys. Acta (1994) [Pubmed]
  5. A cytochrome P450 isozyme having aldehyde oxygenase activity plays a major role in metabolizing cannabinoids by mouse hepatic microsomes. Watanabe, K., Narimatsu, S., Matsunaga, T., Yamamoto, I., Yoshimura, H. Biochem. Pharmacol. (1993) [Pubmed]
  6. Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice. Watanabe, K., Matsunaga, T., Narimatsu, S., Yamamoto, I., Yoshimura, H. Res. Commun. Chem. Pathol. Pharmacol. (1992) [Pubmed]
  7. Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075). Riley, R.J., Hemingway, S.A., Graham, M.A., Workman, P. Biochem. Pharmacol. (1993) [Pubmed]
  8. Possible function of astrocyte cytochrome P450 in control of xenobiotic phenytoin in the brain: in vitro studies on murine astrocyte primary cultures. Meyer, R.P., Knoth, R., Schiltz, E., Volk, B. Exp. Neurol. (2001) [Pubmed]
  9. Oxidative hydrolysis of scoparone by cytochrome p450 CYP2C29 reveals a novel metabolite. Meyer, R.P., Hagemeyer, C.E., Knoth, R., Kurz, G., Volk, B. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  10. Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice. Richardson, T.A., Morgan, E.T. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  11. Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population. Pass, G.J., Becker, W., Kluge, R., Linnartz, K., Plum, L., Giesen, K., Joost, H.G. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  12. Characterization of cannabidiol-mediated cytochrome P450 inactivation. Bornheim, L.M., Everhart, E.T., Li, J., Correia, M.A. Biochem. Pharmacol. (1993) [Pubmed]
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