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Gene Review

Emp1  -  epithelial membrane protein 1

Mus musculus

Synonyms: EMP-1, Epithelial membrane protein 1, I-8-09, TMP, Tmp, ...
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Disease relevance of Emp1

  • The Tmp (tumor-associated membrane protein) gene was isolated from a c-myc induced mouse brain tumor and is expressed in several highly proliferative cell types [1].

High impact information on Emp1


Biological context of Emp1

  • While PMP22 functions mainly in Schwann cell growth and differentiation, the spatio-temporal localization of EMP1 suggests a role in neuronal differentiation and neurite outgrowth [5].
  • We have isolated the Tmp promoter region and identified a putative c-Myc binding element, CACGTG, located in the first intron of the gene [4].
  • To determine whether this alteration in epithelial phenotype is a primary or secondary phenomenon, we examined the epithelial membrane polarity of SBM transgenic mice, in which epithelial proliferation mediated by the c-myc oncogene is an established primary event [6].

Anatomical context of Emp1


Other interactions of Emp1


  1. Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22. Ben-Porath, I., Kozak, C.A., Benvenisty, N. Genomics (1998) [Pubmed]
  2. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. Waxman, A.B., Einarsson, O., Seres, T., Knickelbein, R.G., Warshaw, J.B., Johnston, R., Homer, R.J., Elias, J.A. J. Clin. Invest. (1998) [Pubmed]
  3. Increased potency of an erythropoietin peptide mimetic through covalent dimerization. Wrighton, N.C., Balasubramanian, P., Barbone, F.P., Kashyap, A.K., Farrell, F.X., Jolliffe, L.K., Barrett, R.W., Dower, W.J. Nat. Biotechnol. (1997) [Pubmed]
  4. The tmp gene, encoding a membrane protein, is a c-Myc target with a tumorigenic activity. Ben-Porath, I., Yanuka, O., Benvenisty, N. Mol. Cell. Biol. (1999) [Pubmed]
  5. Embryonic expression of epithelial membrane protein 1 in early neurons. Wulf, P., Suter, U. Brain Res. Dev. Brain Res. (1999) [Pubmed]
  6. Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. Barisoni, L., Trudel, M., Chrétien, N., Ward, L., van Adelsberg, J., D'Agati, V. Am. J. Pathol. (1995) [Pubmed]
  7. Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family. Taylor, V., Welcher, A.A., Program, A.E., Suter, U. J. Biol. Chem. (1995) [Pubmed]
  8. Alteration in goblet cell numbers and mucin gene expression in a mouse model of allergic conjunctivitis. Kunert, K.S., Keane-Myers, A.M., Spurr-Michaud, S., Tisdale, A.S., Gipson, I.K. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  9. Development of Meissner-like and Pacinian sensory corpuscles in the mouse demonstrated with specific markers for corpuscular constituents. Albuerne, M., De Lavallina, J., Esteban, I., Naves, F.J., Silos-Santiago, I., Vega, J.A. Anat. Rec. (2000) [Pubmed]
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