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Gene Review

Emp1  -  epithelial membrane protein 1

Rattus norvegicus

Synonyms: CL-20, EMP-1, ENP1MR, Epithelial membrane protein 1, TMP, ...
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Disease relevance of Emp1


High impact information on Emp1


Biological context of Emp1


Anatomical context of Emp1


Associations of Emp1 with chemical compounds

  • The results indicate both an effect of aprotinin on the epithelial membrane and an inhibition of binding of the thrombin inhibitor to trypsin or other serine proteases in the gut [11].
  • Inhibition was also produced by an EPO mimetic peptide 1 (EMP1), a small synthetic peptide agonist of EPO-R, but not by its inactive analogue in which Cys residues were substituted with Ser [12].
  • To estimate the nasal epithelial membrane and cytoplasmic damaging effect caused by sodium glycocholate (NaGC)-linoleic acid (15 mM:5 mM) mixed micelles, the release profiles of 5'-nucleotidase (5'-ND), lactate dehydrogenase (LDH), and carboxylesterase in the nasal perfusate were measured as a function of time [13].
  • Immunocytochemistry confirmed that these fibroblast-like cells expressed fibronectin and collagen Type III, but not Factor VIII and epithelial membrane antigen (endothelial cell markers) or Mac I (macrophage marker) [14].
  • The LPS-derived cytosol decreased the production of Golgi vesicles by 15% and their fusion with the apical epithelial membrane by 83% [15].

Other interactions of Emp1


  1. Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia. Kawakami, M., Sekiguchi, M., Sato, K., Kozaki, S., Takahashi, M. J. Biol. Chem. (2001) [Pubmed]
  2. Glomerular epithelial detachment, not reduced charge density, correlates with proteinuria in adriamycin and puromycin nephrosis. Whiteside, C., Prutis, K., Cameron, R., Thompson, J. Lab. Invest. (1989) [Pubmed]
  3. Differential effect of macrophage depletion on two forms of experimental uveitis evoked by pigment epithelial membrane protein (EAPU), and by melanin-protein (EMIU). Broekhuyse, R.M., Huitinga, I., Kuhlmann, E.D., Rooijen, N.V., Winkens, H.J. Exp. Eye Res. (1997) [Pubmed]
  4. SNARE expression and localization in renal epithelial cells suggest mechanism for variability of trafficking phenotypes. Li, X., Low, S.H., Miura, M., Weimbs, T. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  5. Epithelial membrane potentials of the epididymis in rats [proceedings]. Cheung, Y.M., Hwang, J.C., Wong, P.Y. J. Physiol. (Lond.) (1976) [Pubmed]
  6. Essential components of antimicrobial gastrointestinal epithelial barrier: specific interaction of mucin with an integral apical membrane protein of gastric mucosa. Slomiany, A., Grabska, M., Slomiany, B.L. Mol. Med. (2001) [Pubmed]
  7. EMP-1 is a junctional protein in a liver stem cell line and in the liver. Lee, H.S., Sherley, J.L., Chen, J.J., Chiu, C.C., Chiou, L.L., Liang, J.D., Yang, P.C., Huang, G.T., Sheu, J.C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. The influence of buffer composition on tissue integrity during permeability experiments "in vitro". Zakelj, S., Legen, I., Veber, M., Kristl, A. International journal of pharmaceutics. (2004) [Pubmed]
  9. Uptake and excretion of [14C]methyl bromide as influenced by exposure concentration. Medinsky, M.A., Dutcher, J.S., Bond, J.A., Henderson, R.F., Mauderly, J.L., Snipes, M.B., Mewhinney, J.A., Cheng, Y.S., Birnbaum, L.S. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  10. Regional difference in effect of filipin in plasma membranes of epithelial cells and surrounding free cells in the choroid plexus. Gotow, T., Hashimoto, P.H. Cell Tissue Res. (1983) [Pubmed]
  11. Inhibition of binding of an enzymatically stable thrombin inhibitor to lumenal proteases as an additional mechanism of intestinal absorption enhancement. Sjöström, M., Lindfors, L., Ungell, A.L. Pharm. Res. (1999) [Pubmed]
  12. Erythropoietin inhibits calcium-induced neurotransmitter release from clonal neuronal cells. Kawakami, M., Iwasaki, S., Sato, K., Takahashi, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  13. Bile salt-fatty acid mixed micelles as nasal absorption promoters. III. Effects on nasal transport and enzymatic degradation of acyclovir prodrugs. Shao, Z., Mitra, A.K. Pharm. Res. (1994) [Pubmed]
  14. Expression of selected osteogenic markers in the fibroblast-like cells of rat marrow stroma. Zhang, R.W., Supowit, S.C., Xu, X., Li, H., Christensen, M.D., Lozano, R., Simmons, D.J. Calcif. Tissue Int. (1995) [Pubmed]
  15. Lipidomic processes in homeostatic and LPS-modified cell renewal cycle. Role of phosphatidylinositol 3-kinase pathway in biomembrane synthesis and restitution of apical epithelial membrane. Slomiany, A., Slomiany, B.L. J. Physiol. Pharmacol. (2003) [Pubmed]
  16. Effects of maternally administered epidermal growth factor on placental permeability. Mimouni, F., Hoath, S.B., Hammond, G. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  17. Effect of dose, pH, and osmolarity on nasal absorption of secretin in rats. III. In vitro membrane permeation test and determination of apparent partition coefficient of secretion. Ohwaki, T., Ishii, M., Aoki, S., Tatsuishi, K., Kayano, M. Chem. Pharm. Bull. (1989) [Pubmed]
  18. Immunocytochemistry of epithelial markers in citral-induced prostate hyperplasia in rats. Massas, R., Servadio, C., Sandbank, U., Abramovici, A. Histol. Histopathol. (1991) [Pubmed]
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