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Gene Review

MAGEC3  -  melanoma antigen family C, 3

Homo sapiens

Synonyms: CT7.2, Cancer/testis antigen 7.2, HCA2, Hepatocellular carcinoma-associated antigen 2, MAGE-C3, ...
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Disease relevance of MAGEC3


High impact information on MAGEC3

  • A broad caspase inhibitor (z-Val-Ala-Asp-fmk) and inhibitors of specific caspases (acetyl-Asp-Glu-Val-Asp-CHO, acetyl-Ile-Glu-Thr-Asp-CHO, and acetyl-Leu-Glu-His-Asp-CHO) suppressed cell death of HCA2/bcl-2 effectively, suggesting involvement of caspase 3-, 8-, and 9-dependent pathways in cell death and that the form of death is apoptosis [5].
  • An MTT assay revealed that BCL-2-overexpressing cells (HCA2/bcl-2) showed more severe growth suppression due to hydrogen peroxide or doxorubicin treatment than vector control cells (HCA2/vector) [5].
  • The same staining pattern was obtained with the 16G1 mAb raised against the soluble HLA-G isoform, whereas neither 87G nor HCA2 reacted with vct but did strongly label the invasive populations of evct, including interstitial and endovascular trophoblasts [6].
  • Furthermore, telomerase-immortalized HCA2 cells proved capable of supporting the stable maintenance of an EBV-based episomal vector with efficient transgene expression when driven by the HCMV immediate early promoter [1].
  • Immortalized MRC-5-hTERT and also HCA2-hTERT human fibroblasts were both fully permissive for HCMV as determined by plaque assay, studies of virus growth kinetics and measurement of virus yields [1].

Biological context of MAGEC3


Anatomical context of MAGEC3

  • Antibodies HCA2, TP25.99, W6/32 to classical HLA class I, anti-beta(2)-m and various non-HLA-G expressing cell lines were used as controls [8].

Associations of MAGEC3 with chemical compounds


Analytical, diagnostic and therapeutic context of MAGEC3

  • MHC class I expression was investigated in 47 OSCCs by immunohistochemistry using HCA2, HC10 and beta2-m antibodies [10].
  • HCA2 and HC10 also produce strong reactivity in immuno-electron microscopy [9].
  • HCA2 and HC10 indeed retain strong reactivity with free class I heavy chains in Western blots [9].
  • Cell surface flow cytometry analysis using the HCA2 mAb revealed that only the HLA-G1 isoform was expressed as a membrane-bound protein [11].


  1. Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus. McSharry, B.P., Jones, C.J., Skinner, J.W., Kipling, D., Wilkinson, G.W. J. Gen. Virol. (2001) [Pubmed]
  2. Influence of 1 and 25 Hz, 1.5 mT magnetic fields on antitumor drug potency in a human adenocarcinoma cell line. Ruiz-Gómez, M.J., de la Peña, L., Prieto-Barcia, M.I., Pastor, J.M., Gil, L., Martínez-Morillo, M. Bioelectromagnetics. (2002) [Pubmed]
  3. 25 Hz electromagnetic field exposure has no effect on cell cycle distribution and apoptosis in U-937 and HCA-2/1cch cells. Ruiz Gómez, M.J., De la Peña, L., Pastor, J.M., Martínez Morillo, M., Gil, L. Bioelectrochemistry (Amsterdam, Netherlands) (2001) [Pubmed]
  4. HLA antigen expression in routinely processed head and neck squamous cell carcinoma primary lesions of different sites. Mattijssen, V., De Mulder, P.H., Schalkwijk, L., Manni, J.J., Van 't Hof-Grootenboer, B., Ruiter, D.J. Int. J. Cancer Suppl. (1991) [Pubmed]
  5. Life span shortening of normal fibroblasts by overexpression of BCL-2: a result of potent increase in cell death. Kumazaki, T., Sasaki, M., Nishiyama, M., Teranishi, Y., Sumida, H., Eboshida, A., Mitsui, Y. Exp. Cell Res. (2003) [Pubmed]
  6. Endothelial cells in chorionic fetal vessels of first trimester placenta express HLA-G. Blaschitz, A., Lenfant, F., Mallet, V., Hartmann, M., Bensussan, A., Geraghty, D.E., Le Bouteiller, P., Dohr, G. Eur. J. Immunol. (1997) [Pubmed]
  7. Multidrug resistance increment in a human colon carcinoma cell line by colchicine. Ruiz Gómez, M.J., Gil, L., Souviron, A., Martínez Morillo, M. Journal of physiology and biochemistry. (2000) [Pubmed]
  8. Reaction patterns of monoclonal antibodies to HLA-G in human tissues and on cell lines: a comparative study. Blaschitz, A., Hutter, H., Leitner, V., Pilz, S., Wintersteiger, R., Dohr, G., Sedlmayr, P. Hum. Immunol. (2000) [Pubmed]
  9. HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy. Stam, N.J., Vroom, T.M., Peters, P.J., Pastoors, E.B., Ploegh, H.L. Int. Immunol. (1990) [Pubmed]
  10. Lack of MHC class I surface expression on neoplastic cells and poor activation of the secretory pathway of cytotoxic cells in oral squamous cell carcinomas. Cruz, I., Meijer, C.J., Walboomers, J.M., Snijders, P.J., Van der Waal, I. Br. J. Cancer (1999) [Pubmed]
  11. The full length HLA-G1 and no other alternative form of HLA-G is expressed at the cell surface of transfected cells. Mallet, V., Pröll, J., Solier, C., Aguerre-Girr, M., DeRossi, M., Loke, Y.W., Lenfant, F., Le Bouteiller, P. Hum. Immunol. (2000) [Pubmed]
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