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Gene Review

Evx1  -  even skipped homeotic gene 1 homolog

Mus musculus

Synonyms: EVX-1, Evx-1, Homeobox even-skipped homolog protein 1
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Disease relevance of Evx1

  • An oligonucleotide segment containing this TRE/AP-1 site was found to confer Evx-1 inducibility on a simian virus 40 minimal promoter; mutation of the TRE/AP-1 site abolished this activity [1].

High impact information on Evx1


Biological context of Evx1


Anatomical context of Evx1

  • Finally, T and Evx1 display ectopic expression in cells not normally fated to ingress through the primitive streak [7].
  • The Evx1- and Evx2-like central nervous system expression observed in these mice suggests that the long-range regulatory element(s) for the Hox cluster existed before the cluster duplication [8].
  • From days 7 to 9 p.c. Evx 1 expression emerges at the posterior end of the embryo within the primitive ectoderm, and later in the mesoderm and neuroectoderm [5].
  • From days 10 to 12.5 p.c. Evx 1 transcripts are restricted to specific cells within the neural tube and hindbrain along their entire lengths and coincides temporally, as well as spatially, with maturation of early forming interneurons, possibly commissural interneurons [5].
  • We describe here the temporal and spatial pattern of expression of Evx-1, a murine homolog of the Drosophila even-skipped gene, in the developing limb bud [9].

Regulatory relationships of Evx1

  • Conversely, misexpression of Evx1 represses En1, suggesting that Evx1 may suppress the V1 interneuron differentiation program [4].
  • FGF-4 regulates expression of Evx-1 in the developing mouse limb [9].

Other interactions of Evx1

  • Posteriorly, the expression domain overlapped with the Evx-1 expression in the streak, while anteriorly it was delimited by the Pax-6 signal in the neural tube [6].
  • Results of wholemount in situ analysis show that the mRNA levels of Evx-1, Wnt-3a and Wnt-5a decrease in T/T embryos late in gastrulation, although earlier expression patterns are similar to control embryos [10].
  • At all these stages, Evx-1 RNA is localized primarily to the posterior distal mesenchyme, in the region immediately underlying that portion of the ridge in which the Fgf-4 gene is expressed [9].
  • Activation of the cytotactin promoter by the homeobox-containing gene Evx-1 [1].


  1. Activation of the cytotactin promoter by the homeobox-containing gene Evx-1. Jones, F.S., Chalepakis, G., Gruss, P., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Pierani, A., Brenner-Morton, S., Chiang, C., Jessell, T.M. Cell (1999) [Pubmed]
  3. Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Spyropoulos, D.D., Capecchi, M.R. Genes Dev. (1994) [Pubmed]
  4. Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord. Moran-Rivard, L., Kagawa, T., Saueressig, H., Gross, M.K., Burrill, J., Goulding, M. Neuron (2001) [Pubmed]
  5. A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner. Bastian, H., Gruss, P. EMBO J. (1990) [Pubmed]
  6. Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Schubert, F.R., Fainsod, A., Gruenbaum, Y., Gruss, P. Mech. Dev. (1995) [Pubmed]
  7. The eed mutation disrupts anterior mesoderm production in mice. Faust, C., Schumacher, A., Holdener, B., Magnuson, T. Development (1995) [Pubmed]
  8. Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication. Lehoczky, J.A., Williams, M.E., Innis, J.W. Evol. Dev. (2004) [Pubmed]
  9. FGF-4 regulates expression of Evx-1 in the developing mouse limb. Niswander, L., Martin, G.R. Development (1993) [Pubmed]
  10. Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryos. Rashbass, P., Wilson, V., Rosen, B., Beddington, R.S. Int. J. Dev. Biol. (1994) [Pubmed]
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