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Gene Review

TNC  -  tenascin C

Gallus gallus

Synonyms: GMEM, JI, TN, TN-C
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Disease relevance of TNC


High impact information on TNC


Biological context of TNC


Anatomical context of TNC

  • An 8.0-kilobase message and a Mr 240,000 cytotactin polypeptide were present in embryonic gizzard but not brain, while a 7.2-kilobase message and a Mr 220,000 polypeptide were present in brain but not gizzard [7].
  • Moreover, innervation may regulate the relative amount and distribution of cytotactin both in muscle and in Schwann cells [8].
  • Peripheral nerve damage resulted in modulation of expression of cytotactin in both nerve and muscle, particularly among the interacting tissues during regeneration and reinnervation [8].
  • In an attempt to extend these observations to the peripheral nervous system, we have examined the distribution and localization of cytotactin in different parts of the normal and regenerating neuromuscular system [8].
  • In the normal neuromuscular system, cytotactin accumulated at critical sites of cell-cell interactions, specifically at the neuromuscular junction and the myotendinous junction, as well at the node of Ranvier (Rieger, F., J. K. Daniloff, M. Pinçon-Raymond, K. L. Crossin, M. Grumet, and G. M. Edelman. 1986. J. Cell Biol. 103:379-391) [8].

Associations of TNC with chemical compounds

  • Cytotactin is an extracellular glycoprotein that influences neuron-glia interactions [7].
  • Constructs containing fragments of the upstream region of the cytotactin gene fused to a promoterless gene for chloramphenicol acetyltransferase were transiently transfected into chicken embryo fibroblasts to define functional promoter sequences [1].
  • Slices of everted small intestine from TN and HS birds were used to study epithelial uptake of methyl labeled 14C-DLM by three transport pathways: diffusion, carrier-specific energy- and sodium-independent uptake (ESI), and carrier-specific energy- and sodium-dependent uptake (ESD) [9].

Physical interactions of TNC


Other interactions of TNC

  • Although cytotactin was identified as a molecule that mediates glia-neuron interactions, preliminary immunohistochemical localization of the molecule suggested that it was an ECM protein with a widespread but nonetheless more restricted distribution than either fibronectin or laminin [11].
  • Sciatic nerves of mouse mutants with defects in cell interactions showed abnormalities in the distribution patterns and amount of Ng-CAM, N-CAM, and cytotactin that were consistent with the known morphological nodal disorders [6].
  • An immunohistochemical study of the localization of cytotactin and cytotactin-binding (CTB) proteoglycan throughout embryonic development of the anuran Xenopus laevis reveals that both appear in a restricted pattern related to specific morphogenetic events [10].

Analytical, diagnostic and therapeutic context of TNC


  1. Identification and characterization of the promoter for the cytotactin gene. Jones, F.S., Crossin, K.L., Cunningham, B.A., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C. Varnum-Finney, B., Venstrom, K., Muller, U., Kypta, R., Backus, C., Chiquet, M., Reichardt, L.F. Neuron (1995) [Pubmed]
  3. The chicken neural extracellular matrix molecule restrictin: similarity with EGF-, fibronectin type III-, and fibrinogen-like motifs. Nörenberg, U., Wille, H., Wolff, J.M., Frank, R., Rathjen, F.G. Neuron (1992) [Pubmed]
  4. Localization during development of alternatively spliced forms of cytotactin mRNA by in situ hybridization. Prieto, A.L., Jones, F.S., Cunningham, B.A., Crossin, K.L., Edelman, G.M. J. Cell Biol. (1990) [Pubmed]
  5. A detailed structural model of cytotactin: protein homologies, alternative RNA splicing, and binding regions. Jones, F.S., Hoffman, S., Cunningham, B.A., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  6. Neuronal cell adhesion molecules and cytotactin are colocalized at the node of Ranvier. Rieger, F., Daniloff, J.K., Pincon-Raymond, M., Crossin, K.L., Grumet, M., Edelman, G.M. J. Cell Biol. (1986) [Pubmed]
  7. A cDNA clone for cytotactin contains sequences similar to epidermal growth factor-like repeats and segments of fibronectin and fibrinogen. Jones, F.S., Burgoon, M.P., Hoffman, S., Crossin, K.L., Cunningham, B.A., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Expression of cytotactin in the normal and regenerating neuromuscular system. Daniloff, J.K., Crossin, K.L., Pinçon-Raymond, M., Murawsky, M., Rieger, F., Edelman, G.M. J. Cell Biol. (1989) [Pubmed]
  9. Effect of heat stress on 2-hydroxy-4-(methylthio)butanoic acid and DL-methionine absorption measured in vitro. Dibner, J.J., Atwell, C.A., Ivey, F.J. Poult. Sci. (1992) [Pubmed]
  10. Distribution and expression of two interactive extracellular matrix proteins, cytotactin and cytotactin-binding proteoglycan, during development of Xenopus laevis. I. Embryonic development. Williamson, D.A., Parrish, E.P., Edelman, G.M. J. Morphol. (1991) [Pubmed]
  11. Site-restricted expression of cytotactin during development of the chicken embryo. Crossin, K.L., Hoffman, S., Grumet, M., Thiery, J.P., Edelman, G.M. J. Cell Biol. (1986) [Pubmed]
  12. Cytotactin expression in somites after dorsal neural tube and neural crest ablation in chicken embryos. Tan, S.S., Prieto, A.L., Newgreen, D.F., Crossin, K.L., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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