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Gene Review

Eya2  -  eyes absent 2 homolog (Drosophila)

Mus musculus

Synonyms: AI327163, Eab1, Eyes absent homolog 2
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High impact information on Eya2

  • Eya1 expression is largely restricted to flexor tendons, while Eya2 is expressed in the extensor tendons and ligaments of the phalangeal elements of the limb [1].
  • Later in limb development, Eya1 and Eya2 expression is associated with cell condensations that form different sets of limb tendons [1].
  • These heterodimers appear to control: (1) the remodeling of the POM through activation of Eya2-related apoptosis; (2) the expression of Foxc1 and Pitx2, which play crucial roles in anterior eye segment development; and (3) the growth of the ventral retina [2].
  • Moreover, Eya1 and Eya2 expressions in the lens and nasal placode overlap with and depend upon expression of Pax6 [3].
  • Eya2 is expressed in neural retina, sclera and optic nerve sheath [3].

Biological context of Eya2


Anatomical context of Eya2


  1. Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Xu, P.X., Cheng, J., Epstein, J.A., Maas, R.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Matt, N., Dupé, V., Garnier, J.M., Dennefeld, C., Chambon, P., Mark, M., Ghyselinck, N.B. Development (2005) [Pubmed]
  3. Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Xu, P.X., Woo, I., Her, H., Beier, D.R., Maas, R.L. Development (1997) [Pubmed]
  4. Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Zimmerman, J.E., Bui, Q.T., Steingrímsson, E., Nagle, D.L., Fu, W., Genin, A., Spinner, N.B., Copeland, N.G., Jenkins, N.A., Bucan, M., Bonini, N.M. Genome Res. (1997) [Pubmed]
  5. Pax3 is essential for skeletal myogenesis and the expression of Six1 and Eya2. Ridgeway, A.G., Skerjanc, I.S. J. Biol. Chem. (2001) [Pubmed]
  6. Eyes absent: a gene family found in several metazoan phyla. Duncan, M.K., Kos, L., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Tomarev, S.I. Mamm. Genome (1997) [Pubmed]
  7. Chicken Eyes absent 2 gene: isolation and expression pattern during development. Mishima, N., Tomarev, S. Int. J. Dev. Biol. (1998) [Pubmed]
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