Disease relevance of Anterior Eye Segment

• Haploinsufficiency of the transcription factor Pax6/PAX6 has been implicated in a number of congenital eye disorders in humans and mice, such as aniridia and Small-eye, which affect the development and function of the lens, cornea, anterior eye segment and neuroretina [1].
• The lens opacity of a selenite-induced cataract in rat pups was monitored using a slit lamp with an anterior eye segment analysis system [2].

High impact information on Anterior Eye Segment

• Morphological changes in the anterior eye segment after long-term treatment with different receptor selective prostaglandin agonists and a prostamide [3].
• PURPOSE: Because in glaucomatous eyes transforming growth factor-beta (TGF-beta) and alphaB-crystallin are increased in the anterior eye segment, the effect of TGF-beta1 and TGF-beta2 on the expression of alphaB-crystallin and its corresponding mRNA was studied in human trabecular meshwork (TM) cells [4].
• The results of this study have demonstrated a target- and peptide-specific effect of short-term diabetes on SP and CGRP expression in ocular nerves of the anterior eye segment [5].
• Localization of substance P-like immunoreactivity in the anterior eye segment of squirrels: an immunohistochemical analysis [6].
• These facts strongly suggest that SP has an important role in the physiologic functions of the anterior eye segment [6].

Biological context of Anterior Eye Segment

• The data provided predict a clinical effect with NAC ophthalmic prodrug, and show that the magnitude and duration of this effect are directly related to the bioavailability of L-carnosine released from NAC in the aqueous humour of the anterior eye segment [7].

Anatomical context of Anterior Eye Segment

• Biochemical studies on the use of sodium hyaluronate in the anterior eye segment. IV. The protective efficacy of the corneal endothelium [8].
• Biochemical studies on the use of sodium hyaluronate in the anterior eye segment. II. The molecular behavior of sodium hyaluronate injected into anterior chamber of rabbits [9].
• Various manipulations of rabbit anterior eye segments were carried out during the initial stages of glutaraldehyde fixation in order to assess the contribution made by particular tissues in restricting the flow of solutes to the ciliary body epithelium [10].

Associations of Anterior Eye Segment with chemical compounds

• The present study investigates the use of a polymer mixture containing Carbopol 974P and drum dried waxy maize starch to obtain prolonged drug release to the anterior eye segment [11].
• Posterior capsule opacification was scored 1 and 2 years after surgery by evaluating retroillumination images taken with a Scheimpflug camera (Nidek Anterior Eye Segment Analysis System) after pupil dilation with phenylephrine 10% and cyclopentolate 1% [12].
• Nerve fibres immunoreactive for nociceptin, nocistatin, and endomorphin 1 or 2 could not be detected in any part of the anterior eye segment [13].
• Anterior eye segments of 20 rat eyes were cut in a tangential plane and the sections stained with antibodies against SP, nociceptin, nocistatin, endomorphin 1 and 2, leu-enkephalin and met-enkephalin [13].
• CONCLUSION: One drop of pilocarpine caused significant changes in the anterior eye segment morphology [14].

Gene context of Anterior Eye Segment

• In the other four longer-term monkeys (3 week, 4 week, 5 week, 2.2 year) the anterior eye segment was investigated with tyrosine hydroxylase immunohistochemistry (TH-IR) and catecholamine fluorescence (CF) [15].
• Measurements of anterior eye segment parameters might provide additional indices for the severity of RP and for the diagnosis of RP subtypes [16].
• By this system, a Scheimpflug and a retroillumination image of the anterior eye segment are obtained through a CCD camera, separately [17].

References