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MeSH Review

Anterior Eye Segment

 
 
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Disease relevance of Anterior Eye Segment

  • Haploinsufficiency of the transcription factor Pax6/PAX6 has been implicated in a number of congenital eye disorders in humans and mice, such as aniridia and Small-eye, which affect the development and function of the lens, cornea, anterior eye segment and neuroretina [1].
  • The lens opacity of a selenite-induced cataract in rat pups was monitored using a slit lamp with an anterior eye segment analysis system [2].
 

High impact information on Anterior Eye Segment

  • Morphological changes in the anterior eye segment after long-term treatment with different receptor selective prostaglandin agonists and a prostamide [3].
  • PURPOSE: Because in glaucomatous eyes transforming growth factor-beta (TGF-beta) and alphaB-crystallin are increased in the anterior eye segment, the effect of TGF-beta1 and TGF-beta2 on the expression of alphaB-crystallin and its corresponding mRNA was studied in human trabecular meshwork (TM) cells [4].
  • The results of this study have demonstrated a target- and peptide-specific effect of short-term diabetes on SP and CGRP expression in ocular nerves of the anterior eye segment [5].
  • Localization of substance P-like immunoreactivity in the anterior eye segment of squirrels: an immunohistochemical analysis [6].
  • These facts strongly suggest that SP has an important role in the physiologic functions of the anterior eye segment [6].
 

Biological context of Anterior Eye Segment

  • The data provided predict a clinical effect with NAC ophthalmic prodrug, and show that the magnitude and duration of this effect are directly related to the bioavailability of L-carnosine released from NAC in the aqueous humour of the anterior eye segment [7].
 

Anatomical context of Anterior Eye Segment

 

Associations of Anterior Eye Segment with chemical compounds

 

Gene context of Anterior Eye Segment

References

  1. Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Davis-Silberman, N., Kalich, T., Oron-Karni, V., Marquardt, T., Kroeber, M., Tamm, E.R., Ashery-Padan, R. Hum. Mol. Genet. (2005) [Pubmed]
  2. Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats. Wang, S., Li, D., Ito, Y., Nabekura, T., Wang, S., Zhang, J., Wu, C. Curr. Eye Res. (2004) [Pubmed]
  3. Morphological changes in the anterior eye segment after long-term treatment with different receptor selective prostaglandin agonists and a prostamide. Richter, M., Krauss, A.H., Woodward, D.F., Lütjen-Drecoll, E. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  4. AlphaB-crystallin in the trabecular meshwork is inducible by transforming growth factor-beta. Welge-Lüssen, U., May, C.A., Eichhorn, M., Bloemendal, H., Lütjen-Drecoll, E. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  5. The effect of diabetes on neuropeptide content in the rat cornea and iris. Marfurt, C.F., Echtenkamp, S.F. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  6. Localization of substance P-like immunoreactivity in the anterior eye segment of squirrels: an immunohistochemical analysis. Shimizu, Y., Kuwayama, Y., Fukuda, M., Ishimoto, I., Shiosaka, S., Inagaki, S., Takagi, H., Sakanaka, M., Senba, E., Kawai, Y., Takatsuki, K., Tohyama, M. Invest. Ophthalmol. Vis. Sci. (1982) [Pubmed]
  7. Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention. Babizhayev, M.A. Drugs in R&D. (2005) [Pubmed]
  8. Biochemical studies on the use of sodium hyaluronate in the anterior eye segment. IV. The protective efficacy of the corneal endothelium. Miyauchi, S., Iwata, S. Curr. Eye Res. (1984) [Pubmed]
  9. Biochemical studies on the use of sodium hyaluronate in the anterior eye segment. II. The molecular behavior of sodium hyaluronate injected into anterior chamber of rabbits. Miyauchi, S., Iwata, S. Curr. Eye Res. (1984) [Pubmed]
  10. Diffusion barriers impeding the flow of solutes to the ciliary body epithelium during immersion fixation of rabbit eyes. Assessment of ultrastructural preservation quality by examination of mitochondrial profiles in the electron microscope. England, C., Gartmann, M., van der Zypen, E. Graefes Arch. Clin. Exp. Ophthalmol. (1988) [Pubmed]
  11. Evaluation of a mucoadhesive tablet for ocular use. Ceulemans, J., Vermeire, A., Adriaens, E., Remon, J.P., Ludwig, A. Journal of controlled release : official journal of the Controlled Release Society. (2001) [Pubmed]
  12. Posterior capsule opacification after phacoemulsification in patients with diabetes mellitus. Zaczek, A., Zetterström, C. Journal of cataract and refractive surgery. (1999) [Pubmed]
  13. Substance P and opioid peptidergic innervation of the anterior eye segment of the rat: an immunohistochemical study. Selbach, J.M., Buschnack, S.H., Steuhl, K.P., Kremmer, S., Muth-Selbach, U. J. Anat. (2005) [Pubmed]
  14. Ultrasound biomicroscopic morphometry of the anterior eye segment before and after one drop of pilocarpine. Németh, J., Csákány, B., Pregun, T. International ophthalmology. (1996) [Pubmed]
  15. Superior cervical ganglionectomy in monkeys: light and electron microscopy of the anterior eye segment. Tamm, E.R., Rohen, J.W., Schmidt, K., Robinson, J.C., Wallow, I.H., Kaufman, P.L. Exp. Eye Res. (1997) [Pubmed]
  16. Alterations in anterior segment dimensions in eyes with retinitis pigmentosa. Horneber, M., Gottanka, J., Milam, A.H., Lütjen-Drecoll, E. Graefes Arch. Clin. Exp. Ophthalmol. (1996) [Pubmed]
  17. Application of an anterior eye segment analysis system in clinical cataract research. Sasaki, K., Sakamoto, Y., Shibata, T. Lens and eye toxicity research. (1990) [Pubmed]
 
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