The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Trim63  -  tripartite motif containing 63, E3...

Rattus norvegicus

Synonyms: E3 ubiquitin-protein ligase TRIM63, MuRF-1, MuRF1, Murf, Murf1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Trim63

  • At various time points after induction of sepsis, mRNA levels for MuRF1 and atrogin-1/MAFbx were determined in extensor digitorum longus muscles by real-time PCR [1].
  • MafBx and Murf are two new rat E3 ubiquitin ligases induced in muscle atrophy [2].
  • LPS (750 microg/100 g body weight) induces MafBx and Murf mRNA (respectively, 23-fold and 33-fold after 12 h; P<0.001) [2].

High impact information on Trim63


Chemical compound and disease context of Trim63


Biological context of Trim63


Anatomical context of Trim63

  • Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection [2].
  • Significant correlations were found between expression of MURF-1 messenger RNA, diaphragm force, and type IIx/b fiber dimensions [4].

Associations of Trim63 with chemical compounds

  • In summary, MafBx and Murf mRNA are up-regulated in response to LPS and might play a role in the muscle proteolysis observed [2].
  • RE selectively altered the expression of different components of this pathway: MAFbx, Murf-1, and ubiquitin mRNA abundance were downregulated, whereas C2 and C9 subunits remained elevated [9].
  • The aim of this study was to examine the effect of polyethylene glycol linked to soluble TNFRI (PEG-sTNFRI) on gene expression of the atrogens MuRF-1 and MAFbx in skeletal muscle of arthritic rats [10].

Other interactions of Trim63

  • Expression of genes encoding components of the ubiquitin-proteasome pathway of protein degradation were elevated with HS, including ubiquitin, MAFbx, Murf-1, Nedd4, and XIAP, and proteasome subunits C2 and C9 [9].

Analytical, diagnostic and therapeutic context of Trim63

  • In cell culture experiments the potency of TNF-alpha to stimulate Murf-1/MAFbx expression, the intracellular signaling pathway, and the involvement of the E3-ligases for the impairment of contractility were assessed [3].


  1. Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle. Wray, C.J., Mammen, J.M., Hershko, D.D., Hasselgren, P.O. Int. J. Biochem. Cell Biol. (2003) [Pubmed]
  2. Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection. Dehoux, M.J., van Beneden, R.P., Fernández-Celemín, L., Lause, P.L., Thissen, J.P. FEBS Lett. (2003) [Pubmed]
  3. Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility. Adams, V., Linke, A., Wisloff, U., D??ring, C., Erbs, S., Kr??nkel, N., Witt, C.C., Labeit, S., M??ller-Werdan, U., Schuler, G., Hambrecht, R. Cardiovasc. Res. (2007) [Pubmed]
  4. Rocuronium exacerbates mechanical ventilation-induced diaphragm dysfunction in rats. Testelmans, D., Maes, K., Wouters, P., Gosselin, N., Deruisseau, K., Powers, S., Sciot, R., Decramer, M., Gayan-Ramirez, G. Crit. Care Med. (2006) [Pubmed]
  5. Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis. Krawiec, B.J., Frost, R.A., Vary, T.C., Jefferson, L.S., Lang, C.H. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  6. Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Hong-Brown, L.Q., Pruznak, A.M., Frost, R.A., Vary, T.C., Lang, C.H. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  7. IGF-1 is downregulated in experimental cancer cachexia. Costelli, P., Muscaritoli, M., Bossola, M., Penna, F., Reffo, P., Bonetto, A., Busquets, S., Bonelli, G., Lopez-Soriano, F.J., Doglietto, G.B., Argilés, J.M., Baccino, F.M., Fanelli, F.R. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  8. Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle. Edström, E., Altun, M., Hägglund, M., Ulfhake, B. J. Gerontol. A Biol. Sci. Med. Sci. (2006) [Pubmed]
  9. Effect of flywheel-based resistance exercise on processes contributing to muscle atrophy during unloading in adult rats. Dupont-Versteegden, E.E., Fluckey, J.D., Knox, M., Gaddy, D., Peterson, C.A. J. Appl. Physiol. (2006) [Pubmed]
  10. Tumour necrosis factor blockade did not prevent the increase of muscular muscle RING finger-1 and muscle atrophy F-box in arthritic rats. Granado, M., Mart??n, A.I., Priego, T., L??pez-Calder??n, A., Villan??a, M.A. J. Endocrinol. (2006) [Pubmed]
WikiGenes - Universities