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Gene Review

Trim63  -  tripartite motif-containing 63

Mus musculus

Synonyms: E3 ubiquitin-protein ligase TRIM63, MuRF-1, MuRF1, Murf1, Muscle RING finger protein 1, ...
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Disease relevance of Trim63


High impact information on Trim63

  • Thus, violation of the conserved preference for tyrosine and glycine in D(H) RF1 alters CDR-H3 content and impairs B cell development and antibody production [4].
  • Coincident with this agonist-stimulated interaction, MURF1 blocks PKCepsilon translocation to focal adhesions, which is a critical event in the hypertrophic signaling cascade [2].
  • MURF1 inhibits phenylephrine-induced (but not IGF-1-induced) increases in cell size [2].
  • We define a novel anti-hypertrophic signaling pathway regulated by muscle ring finger protein-1 (MURF1) that inhibits the agonist-stimulated PKC-mediated signaling response in neonatal rat ventricular myocytes [2].
  • Similarly, whereas dexamethasone increased atrogene expression, pretreatment with the glucocorticoid receptor antagonist RU-486 failed to ameliorate the sepsis-induced increase in atrogin-1 and MuRF1 [3].

Biological context of Trim63


Anatomical context of Trim63

  • Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle [3].
  • RAW264.7 cells and J774 cells of murine macrophage cell lines were cultured with chrysotile B (CH) asbestos, crocidolite (CR) asbestos, or MMMFs comprised of glass wool (GW), rock wool (RW), or ceramic (RF1) [6].

Associations of Trim63 with chemical compounds

  • Dex had a more marked effect on MURF-1 expression in C2C12 cells, but did not affect MURF-1 expression in either muscle [1].
  • Thus, under in vivo conditions in mature adult rats, the sepsis-induced increase in muscle atrogin-1 and MuRF1 mRNA appears both glucocorticoid and TNF independent and is unresponsive to leucine [3].
  • To assess the role of D(H) RF1-encoded tyrosine and glycine in regulating CDR-H3 content and potentially influencing B cell function, we created mice limited to a single D(H) encoding asparagine, histidine, and arginines in RF1 [4].

Analytical, diagnostic and therapeutic context of Trim63


  1. MuSK antibody positive myasthenia gravis plasma modifies MURF-1 expression in C2C12 cultures and mouse muscle in vivo. Benveniste, O., Jacobson, L., Farrugia, M.E., Clover, L., Vincent, A. J. Neuroimmunol. (2005) [Pubmed]
  2. Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy. Arya, R., Kedar, V., Hwang, J.R., McDonough, H., Li, H.H., Taylor, J., Patterson, C. J. Cell Biol. (2004) [Pubmed]
  3. Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle. Frost, R.A., Nystrom, G.J., Jefferson, L.S., Lang, C.H. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  4. Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. Ippolito, G.C., Schelonka, R.L., Zemlin, M., Ivanov, I.I., Kobayashi, R., Zemlin, C., Gartland, G.L., Nitschke, L., Pelkonen, J., Fujihashi, K., Rajewsky, K., Schroeder, H.W. J. Exp. Med. (2006) [Pubmed]
  5. Muscle atrophy in Titin M-line deficient mice. Peng, J., Raddatz, K., Labeit, S., Granzier, H., Gotthardt, M. J. Muscle Res. Cell. Motil. (2005) [Pubmed]
  6. Production of nitric oxide elevates nitrosothiol formation resulting in decreased glutathione in macrophages exposed to asbestos or asbestos substitutes. Nishiike, T., Nishimura, Y., Wada, Y., Iguchi, H. Arch. Toxicol. (2005) [Pubmed]
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