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Gene Review

Fbxo32  -  F-box protein 32

Rattus norvegicus

Synonyms: Atrogin-1, Atrogin1, F-box only protein 32, MAFbx, Muscle atrophy F-box protein
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Disease relevance of Fbxo32


High impact information on Fbxo32


Chemical compound and disease context of Fbxo32


Biological context of Fbxo32

  • These data suggest that the anti-TNF agent PEG-sTNFRI did not prevent the increase in E3 ubiquitin-ligating enzymes, MuRF1 and MAFbx, gene expression in the skeletal muscle of arthritic rats [7].
  • Using dietary restriction, we find that it impedes sarcopenia as well as the effects of aging on AKT phosphorylation, FOXO4 phosphorylation, and Atrogin-1/MAFbx and MuRF1 transcript regulation [8].
  • This study evaluated the effect of ES based on chronaxie and rheobase on the expression of the myoD and atrogin-1 genes in denervated tibialis anterior (TA) muscle of Wistar rats [9].

Associations of Fbxo32 with chemical compounds


Other interactions of Fbxo32

  • On the contrary, Atrogin-1/MAFbx and MuRF1 are downregulated in skeletal muscle of 30-month-old rats, and our results suggest that AKT (protein kinase B)-mediated inactivation of forkhead box O 4 (FOXO4) underlies this suppression [8].
  • These results suggest that (1) calpain-3 has a differential role in the early and late stages of regeneration in a calcineurin-dependent manner, and (2) atrogin-1 is involved in the early stages of regeneration independently of calcineurin [12].
  • Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle [10].
  • Expression of genes encoding components of the ubiquitin-proteasome pathway of protein degradation were elevated with HS, including ubiquitin, MAFbx, Murf-1, Nedd4, and XIAP, and proteasome subunits C2 and C9 [11].
  • The forkhead transcriptional factor, a downstream substrate of PI3K, stimulated atrogin-1/MAFbx promoter transcriptional activity markedly [4].

Analytical, diagnostic and therapeutic context of Fbxo32

  • In cell culture experiments the potency of TNF-alpha to stimulate Murf-1/MAFbx expression, the intracellular signaling pathway, and the involvement of the E3-ligases for the impairment of contractility were assessed [5].
  • Electrical stimulation based on chronaxie reduces atrogin-1 and myoD gene expressions in denervated rat muscle [9].
  • Thus, ES based on chronaxie values and applied to denervated muscles using surface electrodes, as normally used in human rehabilitation, was able to reduce the myoD and atrogin-1 gene expressions, which are related to muscular growth and atrophy, respectively [9].
  • RESULTS: Twenty-four hours after a single session of stretch only, the myoD mRNA levels had increased compared with the control group, whereas an increase in the atrogin-1 expression was observed after 2, 3, and 7 stretches [13].


  1. Role of the insulin-like growth factor I decline in the induction of atrogin-1/MAFbx during fasting and diabetes. Dehoux, M., Van Beneden, R., Pasko, N., Lause, P., Verniers, J., Underwood, L., Ketelslegers, J.M., Thissen, J.P. Endocrinology (2004) [Pubmed]
  2. Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle. Wray, C.J., Mammen, J.M., Hershko, D.D., Hasselgren, P.O. Int. J. Biochem. Cell Biol. (2003) [Pubmed]
  3. Myosin loss in denervated rat soleus muscle after dexamethasone treatment. Horinouchi, H., Kumamoto, T., Kimura, N., Ueyama, H., Tsuda, T. Pathobiology (2005) [Pubmed]
  4. Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase. Lee, S.W., Dai, G., Hu, Z., Wang, X., Du, J., Mitch, W.E. J. Am. Soc. Nephrol. (2004) [Pubmed]
  5. Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility. Adams, V., Linke, A., Wisloff, U., D??ring, C., Erbs, S., Kr??nkel, N., Witt, C.C., Labeit, S., M??ller-Werdan, U., Schuler, G., Hambrecht, R. Cardiovasc. Res. (2007) [Pubmed]
  6. IGF-1 is downregulated in experimental cancer cachexia. Costelli, P., Muscaritoli, M., Bossola, M., Penna, F., Reffo, P., Bonetto, A., Busquets, S., Bonelli, G., Lopez-Soriano, F.J., Doglietto, G.B., Argilés, J.M., Baccino, F.M., Fanelli, F.R. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  7. Tumour necrosis factor blockade did not prevent the increase of muscular muscle RING finger-1 and muscle atrophy F-box in arthritic rats. Granado, M., Mart??n, A.I., Priego, T., L??pez-Calder??n, A., Villan??a, M.A. J. Endocrinol. (2006) [Pubmed]
  8. Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle. Edström, E., Altun, M., Hägglund, M., Ulfhake, B. J. Gerontol. A Biol. Sci. Med. Sci. (2006) [Pubmed]
  9. Electrical stimulation based on chronaxie reduces atrogin-1 and myoD gene expressions in denervated rat muscle. Russo, T.L., Peviani, S.M., Freria, C.M., Gigo-Benato, D., Geuna, S., Salvini, T.F. Muscle Nerve (2007) [Pubmed]
  10. Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle. Granado, M., Priego, T., Martín, A.I., Villanúa, M.A., López-Calderón, A. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  11. Effect of flywheel-based resistance exercise on processes contributing to muscle atrophy during unloading in adult rats. Dupont-Versteegden, E.E., Fluckey, J.D., Knox, M., Gaddy, D., Peterson, C.A. J. Appl. Physiol. (2006) [Pubmed]
  12. Expression of tropism-related genes in regenerating skeletal muscle of rats treated with cyclosporin-A. Miyabara, E.H., Aoki, M.S., Soares, A.G., Moriscot, A.S. Cell Tissue Res. (2005) [Pubmed]
  13. The effect of 30 minutes of passive stretch of the rat soleus muscle on the myogenic differentiation, myostatin, and atrogin-1 gene expressions. Gomes, A.R., Soares, A.G., Peviani, S., Nascimento, R.B., Moriscot, A.S., Salvini, T.F. Archives of physical medicine and rehabilitation. (2006) [Pubmed]
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