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Gene Review

Fgf15  -  fibroblast growth factor 15

Mus musculus

Synonyms: FGF-15, FGF19, Fibroblast growth factor 15
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Disease relevance of Fgf15


High impact information on Fgf15

  • We present evidence that Fgf15 shows Shh-dependent expression in the diencephalon and may participate in this interaction, at least in part, by regulating the ability of dorsal neural precursors to respond to dorsally secreted Wnt mitogens [4].
  • The FGF-15 gene is expressed in a regionally restricted pattern in the developing nervous system, suggesting that FGF-15 may play an important role in regulating cell division and patterning within specific regions of the embryonic brain, spinal cord and sensory organs [5].
  • Unlike Fgf19, Fgf15 is not expressed in mesoderm underlying the presumptive otic placode, but is expressed in the adjacent neurectoderm [6].
  • Fibroblast growth factor 15 (Fgf15) is expressed in the developing mouse central nervous system and pharyngeal arches [2].
  • Fgf15 mutant mice showed defects of the cardiac outflow tract probably because of aberrant behavior of the cardiac neural crest cells [2].

Associations of Fgf15 with chemical compounds

  • Ostα(-/-)Fxr(-/-) mice exhibited decreased ileal FGF15 expression, restoration of intestinal cholesterol absorption, and increases in hepatic Cyp7a1 expression, fecal BA excretion, and BA pool size [7].

Biological context of Fgf15


Anatomical context of Fgf15

  • Fgf15 appeared early in the developing neural epithelium, in domains where Fgf8 gene is also expressed and, at later stages, in specific groups of neural cells [8].
  • Fgf15 expression in the diencephalon/midbrain was greatly reduced in the seven-somite Shh mutant embryos [9].

Regulatory relationships of Fgf15

  • In addition, the thalamic expression of Fgf15 has been recently reported under the control of Shh signalling gene, expressed in the diencephalic basal plate (Development 129 (2002) 4807) [8].

Other interactions of Fgf15

  • Luciferase assays and transgenic analysis revealed that the Fgf15 gene is a direct target of Shh [10].
  • Fgf15 expression is localized, like Fgf8, in secondary neural tube organizers: the isthmic organizer (IsO) and the anterior neural ridge (ANR) [8].
  • The Fgf15 expression domain coincided with that of Gli1 and overlapped with that of Gli2 at this stage [9].
  • This appears to result in a failure to establish an ectodermal signalling center expressing Fgf3 and Fgf15 [11].
  • Here we analyze the expression of Fgf15 at different stages of mouse development in relation to Fgf8 and Otx2 expression patterns [12].


  1. Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Vincentz, J.W., McWhirter, J.R., Murre, C., Baldini, A., Furuta, Y. Genesis (2005) [Pubmed]
  2. Analysis of Fibroblast growth factor 15 cis-elements reveals two conserved enhancers which are closely related to cardiac outflow tract development. Saitsu, H., Shiota, K., Ishibashi, M. Mech. Dev. (2006) [Pubmed]
  3. Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse. Kurose, H., Bito, T., Adachi, T., Shimizu, M., Noji, S., Ohuchi, H. Gene Expr. Patterns (2004) [Pubmed]
  4. A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Ishibashi, M., McMahon, A.P. Development (2002) [Pubmed]
  5. A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. McWhirter, J.R., Goulding, M., Weiner, J.A., Chun, J., Murre, C. Development (1997) [Pubmed]
  6. Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction. Wright, T.J., Ladher, R., McWhirter, J., Murre, C., Schoenwolf, G.C., Mansour, S.L. Dev. Biol. (2004) [Pubmed]
  7. Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism. Lan, T., Rao, A., Haywood, J., Kock, N.D., Dawson, P.A. J. Hepatol. (2012) [Pubmed]
  8. Study of Fgf15 gene expression in developing mouse brain. Gimeno, L., Brûlet, P., Martínez, S. Gene Expr. Patterns (2003) [Pubmed]
  9. Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain. Saitsu, H., Komada, M., Suzuki, M., Nakayama, R., Motoyama, J., Shiota, K., Ishibashi, M. Dev. Dyn. (2005) [Pubmed]
  10. Signaling cascade coordinating growth of dorsal and ventral tissues of the vertebrate brain, with special reference to the involvement of Sonic Hedgehog signaling. Ishibashi, M., Saitsu, H., Komada, M., Shiota, K. Anatomical science international / Japanese Association of Anatomists. (2005) [Pubmed]
  11. Fibroblast growth factor signalling and regional specification of the pharyngeal ectoderm. Trokovic, N., Trokovic, R., Partanen, J. Int. J. Dev. Biol. (2005) [Pubmed]
  12. Analysis of Fgf15 expression pattern in the mouse neural tube. Gimeno, L., Hashemi, R., Brûlet, P., Martínez, S. Brain Res. Bull. (2002) [Pubmed]
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