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Gene Review

FGF19  -  fibroblast growth factor 19

Homo sapiens

Synonyms: FGF-19, Fibroblast growth factor 19, UNQ334/PRO533
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Disease relevance of FGF19


High impact information on FGF19


Biological context of FGF19


Anatomical context of FGF19


Associations of FGF19 with chemical compounds

  • The FGF19 transgenic mice had increased brown adipose tissue mass and decreased liver expression of acetyl coenzyme A carboxylase 2, providing two mechanisms by which FGF19 may increase energy expenditure [7].
  • Basal FGF19 levels varied by 10-fold in normal subjects, and were reduced following treatment with a BA-binding resin and increased upon feeding the BA chenodeoxycholic acid [8].
  • The key heparin-binding loops of FGF19 have radically different conformations and charge patterns, compared to other FGFs, correlating with the unusually low affinity of FGF19 for heparin [11].
  • In all of the mice studied, dietary taurocholate increased ileal expression of FGF15, a FXR-inducible murine homologue of human FGF19 [12].
  • The inhibitory effect of FGF-19 on insulin activation of hepatic fatty acid synthesis constitutes a mechanism that would explain the beneficial effect of FGF-19 on metabolic syndrome [13].

Physical interactions of FGF19

  • The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4 [7].

Other interactions of FGF19

  • The molecular behavior of FGF23 as a systemic factor can be justified by the altered conformation of the beta-trefoil structure similar to that suspected in FGF19 [14].
  • The structure therefore offers a clear explanation for the unusual affinity of FGF19 for FGFR4 alone [11].
  • FGF19 is a target for FOXC1 regulation in ciliary body-derived cells [5].
  • Whereas FGF-20 promoted cell multiplication at low doses, FGF-19 was required at high doses to achieve a comparable effect [4].


  1. A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Nicholes, K., Guillet, S., Tomlinson, E., Hillan, K., Wright, B., Frantz, G.D., Pham, T.A., Dillard-Telm, L., Tsai, S.P., Stephan, J.P., Stinson, J., Stewart, T., French, D.M. Am. J. Pathol. (2002) [Pubmed]
  2. Analysis of Fibroblast growth factor 15 cis-elements reveals two conserved enhancers which are closely related to cardiac outflow tract development. Saitsu, H., Shiota, K., Ishibashi, M. Mech. Dev. (2006) [Pubmed]
  3. FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Xie, M.H., Holcomb, I., Deuel, B., Dowd, P., Huang, A., Vagts, A., Foster, J., Liang, J., Brush, J., Gu, Q., Hillan, K., Goddard, A., Gurney, A.L. Cytokine (1999) [Pubmed]
  4. Effects of fibroblast growth factors 19 and 20 on cell multiplication and locomotion in a human embryonal carcinoma cell line (Tera-2) in vitro. Engstr??m, W., Granerus, M. Anticancer Res. (2006) [Pubmed]
  5. FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. Tamimi, Y., Skarie, J.M., Footz, T., Berry, F.B., Link, B.A., Walter, M.A. Hum. Mol. Genet. (2006) [Pubmed]
  6. Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction. Wright, T.J., Ladher, R., McWhirter, J., Murre, C., Schoenwolf, G.C., Mansour, S.L. Dev. Biol. (2004) [Pubmed]
  7. Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J.P., Tsai, S.P., Powell-Braxton, L., French, D., Stewart, T.A. Endocrinology (2002) [Pubmed]
  8. Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. Lund??sen, T., G??lman, C., Angelin, B., Rudling, M. J. Intern. Med. (2006) [Pubmed]
  9. Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
  10. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Fu, L., John, L.M., Adams, S.H., Yu, X.X., Tomlinson, E., Renz, M., Williams, P.M., Soriano, R., Corpuz, R., Moffat, B., Vandlen, R., Simmons, L., Foster, J., Stephan, J.P., Tsai, S.P., Stewart, T.A. Endocrinology (2004) [Pubmed]
  11. The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. Harmer, N.J., Pellegrini, L., Chirgadze, D., Fernandez-Recio, J., Blundell, T.L. Biochemistry (2004) [Pubmed]
  12. Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4. Gutierrez, A., Ratliff, E.P., Andres, A.M., Huang, X., McKeehan, W.L., Davis, R.A. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  13. Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. Bhatnagar, S., Damron, H.A., Hillgartner, F.B. J. Biol. Chem. (2009) [Pubmed]
  14. Structural and biochemical properties of fibroblast growth factor 23. Yamashita, T. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. (2005) [Pubmed]
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