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Gene Review

Hoxd10  -  homeobox D10

Mus musculus

Synonyms: AI385591, AI874987, Homeobox protein Hox-4.5, Homeobox protein Hox-5.3, Homeobox protein Hox-D10, ...
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High impact information on Hoxd10

  • In mutant embryos, expression of both Hoxd-11 and Hoxd-10 mRNAs in the prevertebral column is anteriorized [1].
  • Hoxd-10 expression affects head and thorax, but not the abdomen [2].
  • This study reports the expression domains of two murine HOX gene members of the HOX-5 complex (Hox-5.2, Hox-5.3) [3].
  • The partial characterization of this gene cluster revealed the presence of two novel genes (Hox-5.2, Hox-5.3) located at the 5' extremity of this complex [4].
  • These observations suggest a role for the Hoxd-10 gene in establishing regional identity within the spinal cord and imply that patterning of the spinal cord may have intrinsic components and is not completely imposed by the surrounding mesoderm [5].

Biological context of Hoxd10


Anatomical context of Hoxd10


Regulatory relationships of Hoxd10

  • Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression [8].

Other interactions of Hoxd10

  • These observations suggest that Hoxa10 and Hoxd10 coordinately regulate skeletal development and innervation of the hindlimb [10].

Analytical, diagnostic and therapeutic context of Hoxd10

  • Using cDNA microarrays to study a single gene knockout during critical developmental stages has identified a large number of genes regulated by Hoxd10, many of which would not have been approached as candidates for Hox gene regulation based on function or expression [6].
  • Nine genes showed changes in expression of the same sign and similar magnitude using RT-PCR in Hoxd10 single mutant animals, with additional changes in expression seen in Hoxa10/Hoxd10 double mutant animals [6].


  1. In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. Gérard, M., Chen, J.Y., Gronemeyer, H., Chambon, P., Duboule, D., Zákány, J. Genes Dev. (1996) [Pubmed]
  2. Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes. Bachiller, D., Macías, A., Duboule, D., Morata, G. EMBO J. (1994) [Pubmed]
  3. Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads. Dollé, P., Duboule, D. EMBO J. (1989) [Pubmed]
  4. The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. Duboule, D., Dollé, P. EMBO J. (1989) [Pubmed]
  5. Targeted disruption of Hoxd-10 affects mouse hindlimb development. Carpenter, E.M., Goddard, J.M., Davis, A.P., Nguyen, T.P., Capecchi, M.R. Development (1997) [Pubmed]
  6. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. Hedlund, E., Karsten, S.L., Kudo, L., Geschwind, D.H., Carpenter, E.M. J. Neurosci. Res. (2004) [Pubmed]
  7. Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum. Zákány, J., Gérard, M., Favier, B., Duboule, D. EMBO J. (1997) [Pubmed]
  8. Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression. Rijli, F.M., Dollé, P., Fraulob, V., LeMeur, M., Chambon, P. Dev. Dyn. (1994) [Pubmed]
  9. Dinucleotide repeats in the mouse Hox-4.4 and Hox-4.5 genes on chromosome 2, and their analysis in the BXD and BXH recombinant inbred strains. Pilz, A.J., Abbott, C.M. Mamm. Genome (1993) [Pubmed]
  10. The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton. Wahba, G.M., Hostikka, S.L., Carpenter, E.M. Dev. Biol. (2001) [Pubmed]
  11. Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. de la Cruz, C.C., Der-Avakian, A., Spyropoulos, D.D., Tieu, D.D., Carpenter, E.M. Dev. Biol. (1999) [Pubmed]
  12. Hoxa10 and Hoxd10 coordinately regulate lumbar motor neuron patterning. Lin, A.W., Carpenter, E.M. J. Neurobiol. (2003) [Pubmed]
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