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Gene Review

Hoxd9  -  homeobox D9

Mus musculus

Synonyms: Homeobox protein Hox-4.4, Homeobox protein Hox-5.2, Homeobox protein Hox-D9, Hox-4.4, Hox-5.2, ...
 
 
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High impact information on Hoxd9

  • Such a local and transient break in colinearity was also observed after transposition of the Hoxd9/lacZ reporter gene, indicating that it may be a general property of these transgenes when transposed at an ectopic location [1].
  • The latter gradient has the opposite polarity to that of Hox-5.2. i.e., maximal in anterior and proximal mesoderm [2].
  • Hox-5.2 antigen is detected strongly in developing fore- and hindlimb buds, where it forms a gradient of nuclear protein throughout most of the mesenchyme [2].
  • Unexpectedly, when the distribution of Hox-5.2 antigen was compared with that of X1Hbox 1 antigen, a non-overlapping and mutually exclusive pattern was detected (e.g., in developing limb buds, intestine, and somites) [2].
  • A new human homeo box-containing gene designated Hox-5.2 was cloned and mapped to human chromosome 2 [2].
 

Biological context of Hoxd9

 

Anatomical context of Hoxd9

  • Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development [7].
  • Hoxa9, Hoxb9, and Hoxd9 are expressed normally in adult mammary glands, suggesting a direct role for these genes in the development of mammary tissue after pregnancy [8].
  • Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous genes are required for mediating the expansion and/or differentiation of the mammary epithelium ductal system in response to pregnancy [8].
  • Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning [5].
 

Regulatory relationships of Hoxd9

  • Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression [9].
 

Other interactions of Hoxd9

 

Analytical, diagnostic and therapeutic context of Hoxd9

References

  1. Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex. Kmita, M., van Der Hoeven, F., Zákány, J., Krumlauf, R., Duboule, D. Genes Dev. (2000) [Pubmed]
  2. Complementary homeo protein gradients in developing limb buds. Oliver, G., Sidell, N., Fiske, W., Heinzmann, C., Mohandas, T., Sparkes, R.S., De Robertis, E.M. Genes Dev. (1989) [Pubmed]
  3. Differential expression of two different homeobox gene families during mouse tegument morphogenesis. Kanzler, B., Viallet, J.P., Le Mouellic, H., Boncinelli, E., Duboule, D., Dhouailly, D. Int. J. Dev. Biol. (1994) [Pubmed]
  4. The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. Duboule, D., Dollé, P. EMBO J. (1989) [Pubmed]
  5. Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Fromental-Ramain, C., Warot, X., Lakkaraju, S., Favier, B., Haack, H., Birling, C., Dierich, A., Doll e, P., Chambon, P. Development (1996) [Pubmed]
  6. Dinucleotide repeats in the mouse Hox-4.4 and Hox-4.5 genes on chromosome 2, and their analysis in the BXD and BXH recombinant inbred strains. Pilz, A.J., Abbott, C.M. Mamm. Genome (1993) [Pubmed]
  7. Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. de la Cruz, C.C., Der-Avakian, A., Spyropoulos, D.D., Tieu, D.D., Carpenter, E.M. Dev. Biol. (1999) [Pubmed]
  8. Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Chen, F., Capecchi, M.R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression. Rijli, F.M., Dollé, P., Fraulob, V., LeMeur, M., Chambon, P. Dev. Dyn. (1994) [Pubmed]
 
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