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Gene Review

Lamb2  -  laminin, beta 2

Mus musculus

Synonyms: AW211941, Lamb-2, Laminin subunit beta-2, Laminin-11 subunit beta, Laminin-14 subunit beta, ...
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Disease relevance of Lamb2


High impact information on Lamb2

  • S-laminin/laminin beta 2, a homologue of the widely distributed laminin B1/beta 1 chain, is a major component of adult renal glomerular basement membrane (GBM) [4].
  • In this issue of the JCI, Jarad et al. show that in laminin beta2-deficient (Lamb2-/-) mice, proteinuria can be directly attributed to the altered composition of the GBM (see the related article beginning on page 2272) [5].
  • Lamb2(-/-) mice are a model for Pierson syndrome; they exhibit defects in the kidney glomerular barrier, in the development and organization of the neuromuscular junction, and in the retina [1].
  • N-CAM, 43K-rapsyn, and S-laminin mRNAs are concentrated at synaptic sites in muscle fibers [6].
  • S-laminin: mapping to mouse chromosome 9 and expression in the linked mutants tippy and ducky [7].

Biological context of Lamb2

  • Lamb2(-/-) mice fail to thrive and die very small at 3 weeks of age, but to what extent the kidney and neuromuscular defects each contribute to this severe phenotype has been obscure, though highly relevant to understanding Pierson syndrome [1].
  • A significant association was found between postrestraint rearings during min 5 through 8 in the open field and the Lamb2 marker on chromosome 1 (r = .718, p < .0001) [8].

Anatomical context of Lamb2


Other interactions of Lamb2


Analytical, diagnostic and therapeutic context of Lamb2


  1. Transgenic isolation of skeletal muscle and kidney defects in laminin beta2 mutant mice: implications for Pierson syndrome. Miner, J.H., Go, G., Cunningham, J., Patton, B.L., Jarad, G. Development (2006) [Pubmed]
  2. Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. Jarad, G., Cunningham, J., Shaw, A.S., Miner, J.H. J. Clin. Invest. (2006) [Pubmed]
  3. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Subramanian, S., Tus, K., Li, Q.Z., Wang, A., Tian, X.H., Zhou, J., Liang, C., Bartov, G., McDaniel, L.D., Zhou, X.J., Schultz, R.A., Wakeland, E.K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1. Noakes, P.G., Miner, J.H., Gautam, M., Cunningham, J.M., Sanes, J.R., Merlie, J.P. Nat. Genet. (1995) [Pubmed]
  5. The glomerular basement membrane: not gone, just forgotten. Farquhar, M.G. J. Clin. Invest. (2006) [Pubmed]
  6. N-CAM, 43K-rapsyn, and S-laminin mRNAs are concentrated at synaptic sites in muscle fibers. Moscoso, L.M., Merlie, J.P., Sanes, J.R. Mol. Cell. Neurosci. (1995) [Pubmed]
  7. S-laminin: mapping to mouse chromosome 9 and expression in the linked mutants tippy and ducky. Porter, B.E., Justice, M.J., Copeland, N.G., Jenkins, N.A., Hunter, D.D., Merlie, J.P., Sanes, J.R. Genomics (1993) [Pubmed]
  8. Quantitative trait loci associated with the behavioral response of B x D recombinant inbred mice to restraint stress: a preliminary communication. Tarricone, B.J., Hingtgen, J.N., Belknap, J.K., Mitchell, S.R., Nurnberger, J.I. Behav. Genet. (1995) [Pubmed]
  9. Ganglioside characterization of a cell line displaying motor neuron-like phenotype: GM2 as a possible major ganglioside in motor neurons. Matsumoto, A., Yoshino, H., Yuki, N., Hara, Y., Cashman, N.R., Handa, S., Miyatake, T. J. Neurol. Sci. (1995) [Pubmed]
  10. Immunoregulation in experimental autoimmune myasthenia gravis--about T cells, antibodies, and endplates. De Baets, M., Stassen, M., Losen, M., Zhang, X., Machiels, B. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
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