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Gene Review

Ncam1  -  neural cell adhesion molecule 1

Rattus norvegicus

Synonyms: Cd56, N-CAM, N-CAM-1, NCAM-1, NCAM-C, ...
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Disease relevance of Ncam1


Psychiatry related information on Ncam1


High impact information on Ncam1


Chemical compound and disease context of Ncam1


Biological context of Ncam1


Anatomical context of Ncam1


Associations of Ncam1 with chemical compounds

  • We have recently identified a neuritogenic ligand, termed the C3 peptide, of the first immunoglobulin (lg) module of NCAM using a combinatorial library of synthetic peptides [20].
  • Immunostaining results demonstrated the wide distribution of integrin alphav and NCAM in all mesencephalic neurons [4].
  • These results demonstrate that integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival and outgrowth during development and on DA turnover and motor function during adulthood [4].
  • Extracellular adenosine triphosphate affects neural cell adhesion molecule (NCAM)-mediated cell adhesion and neurite outgrowth [17].
  • On postnatal day 2, NCAM expression was decreased in rat cerebral cortex, and reelin expression was decreased in hippocampus from levels in controls without maternal thromboxane exposure [11].

Physical interactions of Ncam1


Regulatory relationships of Ncam1


Other interactions of Ncam1

  • An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons [15].
  • Furthermore, we were able to show that binding of these novel binding proteins, as well as the previously described interaction partners ROK alpha (rho A binding kinase alpha) and alpha- and beta-tubulin, bind to specific cytosolic sequences of NCAM [1].
  • These results collectively indicate that NCAM and tPA reciprocally act as important regulators in the modulation of synaptic plasticity via a Ras-MAPK-involved signaling pathway [29].
  • Whereas primary islet cells at all ages express unsialylated NCAM and E-cadherin, as do insulinomas, the glucagonomas express the polysialylated NCAM, which is characteristic for developing neurons [3].
  • No significant differences in NCAM expression were seen in hippocampus, nor did reelin expression differ in cerebral cortex between control and IUGR groups [11].

Analytical, diagnostic and therapeutic context of Ncam1


  1. Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A. Büttner, B., Kannicht, C., Reutter, W., Horstkorte, R. Biochemistry (2005) [Pubmed]
  2. Enriched NCAM-Positive Cells Form Functional Dopaminergic Neurons in the Rat Model of Parkinson's Disease. Ravindran, G., Rao, H.S. Stem Cells Dev. (2006) [Pubmed]
  3. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Møller, C.J., Christgau, S., Williamson, M.R., Madsen, O.D., Niu, Z.P., Bock, E., Baekkeskov, S. Mol. Endocrinol. (1992) [Pubmed]
  4. Integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats. Chao, C.C., Ma, Y.L., Chu, K.Y., Lee, E.H. Neurobiol. Aging (2003) [Pubmed]
  5. A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation. Cambon, K., Hansen, S.M., Venero, C., Herrero, A.I., Skibo, G., Berezin, V., Bock, E., Sandi, C. J. Neurosci. (2004) [Pubmed]
  6. Neurobiological and endocrine correlates of individual differences in spatial learning ability. Sandi, C., Cordero, M.I., Merino, J.J., Kruyt, N.D., Regan, C.M., Murphy, K.J. Learn. Mem. (2004) [Pubmed]
  7. Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats. Baydas, G., Yasar, A., Tuzcu, M. J. Pineal Res. (2005) [Pubmed]
  8. Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe. Murphy, K.J., Fox, G.B., Foley, A.G., Gallagher, H.C., O'Connell, A., Griffin, A.M., Nau, H., Regan, C.M. J. Neurochem. (2001) [Pubmed]
  9. Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. Lüthl, A., Laurent, J.P., Figurov, A., Muller, D., Schachner, M. Nature (1994) [Pubmed]
  10. The VASE exon downregulates the neurite growth-promoting activity of NCAM 140. Doherty, P., Moolenaar, C.E., Ashton, S.V., Michalides, R.J., Walsh, F.S. Nature (1992) [Pubmed]
  11. Underexpression of neural cell adhesion molecule and neurotrophic factors in rat brain following thromboxane A(2)-induced intrauterine growth retardation. Fukami, E., Nakayama, A., Sasaki, J., Mimura, S., Mori, N., Watanabe, K. Early Hum. Dev. (2000) [Pubmed]
  12. Localization of neural cell adhesion molecule and pan-cadherin immunoreactivity in intrauterine growth-retarded newborn rat kidneys. Filiz, S., Dalcik, C., Filiz, T.M., Dalcik, H. Appl. Immunohistochem. Mol. Morphol. (2003) [Pubmed]
  13. The nerve growth factor-inducible large external (NILE) glycoprotein and neural cell adhesion molecule (N-CAM) have distinct patterns of expression in the developing rat central nervous system. Beasley, L., Stallcup, W.B. J. Neurosci. (1987) [Pubmed]
  14. The embryonic form of neural cell surface molecule (E-NCAM) in the rat hippocampus and its reexpression on glial cells following kainic acid-induced status epilepticus. Le Gal La Salle, G., Rougon, G., Valin, A. J. Neurosci. (1992) [Pubmed]
  15. An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons. Neiiendam, J.L., Køhler, L.B., Christensen, C., Li, S., Pedersen, M.V., Ditlevsen, D.K., Kornum, M.K., Kiselyov, V.V., Berezin, V., Bock, E. J. Neurochem. (2004) [Pubmed]
  16. Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Saffell, J.L., Williams, E.J., Mason, I.J., Walsh, F.S., Doherty, P. Neuron (1997) [Pubmed]
  17. Extracellular adenosine triphosphate affects neural cell adhesion molecule (NCAM)-mediated cell adhesion and neurite outgrowth. Skladchikova, G., Ronn, L.C., Berezin, V., Bock, E. J. Neurosci. Res. (1999) [Pubmed]
  18. Polypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing. Small, S.J., Haines, S.L., Akeson, R.A. Neuron (1988) [Pubmed]
  19. Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. Niethammer, P., Delling, M., Sytnyk, V., Dityatev, A., Fukami, K., Schachner, M. J. Cell Biol. (2002) [Pubmed]
  20. Neurite outgrowth induced by a synthetic peptide ligand of neural cell adhesion molecule requires fibroblast growth factor receptor activation. Rønn, L.C., Doherty, P., Holm, A., Berezin, V., Bock, E. J. Neurochem. (2000) [Pubmed]
  21. Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kölliker's organ. Simonneau, L., Gallego, M., Pujol, R. J. Comp. Neurol. (2003) [Pubmed]
  22. Rat oligodendrocyte O-2A precursor cells and the CG-4 oligodendrocyte precursor cell line express cadherins, beta-catenin and the neural cell adhesion molecule, NCAM. Hughson, E., Dowler, S., Geall, K., Johnson, G., Rumsby, M. Neurosci. Lett. (1998) [Pubmed]
  23. A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo. Skibo, G.G., Lushnikova, I.V., Voronin, K.Y., Dmitrieva, O., Novikova, T., Klementiev, B., Vaudano, E., Berezin, V.A., Bock, E. Eur. J. Neurosci. (2005) [Pubmed]
  24. Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation. Krushel, L.A., Tai, M.H., Cunningham, B.A., Edelman, G.M., Crossin, K.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  25. A peptide from the first fibronectin domain of NCAM acts as an inverse agonist and stimulates FGF receptor activation, neurite outgrowth and survival. Anderson, A.A., Kendal, C.E., Garcia-Maya, M., Kenny, A.V., Morris-Triggs, S.A., Wu, T., Reynolds, R., Hohenester, E., Saffell, J.L. J. Neurochem. (2005) [Pubmed]
  26. Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair. Knittel, T., Dinter, C., Kobold, D., Neubauer, K., Mehde, M., Eichhorst, S., Ramadori, G. Am. J. Pathol. (1999) [Pubmed]
  27. NMDA receptor and nitric oxide synthase activation regulate polysialylated neural cell adhesion molecule expression in adult brainstem synapses. Bouzioukh, F., Tell, F., Jean, A., Rougon, G. J. Neurosci. (2001) [Pubmed]
  28. Developmental control of N-CAM sialylation state by Golgi sialyltransferase isoforms. Breen, K.C., Regan, C.M. Development (1988) [Pubmed]
  29. Reciprocal actions of NCAM and tPA via a Ras-dependent MAPK activation in rat hippocampal neurons. Son, H., Seuk Kim, J., Mogg Kim, J., Lee, S.H., Lee, Y.S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  30. Removal of PSA from NCAM affects the survival of magnocellular vasopressin- and oxytocin-producing neurons in organotypic cultures of the paraventricular nucleus. Vutskits, L., Gascon, E., Kiss, J.Z. Eur. J. Neurosci. (2003) [Pubmed]
  31. Distribution of polysialylated neural cell adhesion molecule in rat septal nuclei and septohippocampal pathway: transient increase of polysialylated interneurons in the subtriangular septal zone during memory consolidation. Foley, A.G., Rønn, L.C., Murphy, K.J., Regan, C.M. J. Neurosci. Res. (2003) [Pubmed]
  32. Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses. Dityatev, A., Dityateva, G., Sytnyk, V., Delling, M., Toni, N., Nikonenko, I., Muller, D., Schachner, M. J. Neurosci. (2004) [Pubmed]
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