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Gene Review

Arr3  -  arrestin 3, retinal (X-arrestin)

Rattus norvegicus

Synonyms: Arrestin-C, Car, Cone arrestin, Retinal cone arrestin-3, cArr
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Disease relevance of Arr3

  • In conclusion, a synthetic polyamine-deficient diet had a significant general analgesic effect on Car-induced mechanical hyperalgesia [1].
  • RESULTS: Car-induced paw edema was inhibited by 36.6% (P < 0.01) at 3 h and 34.6% (P < 0.01) at 5 h after a single i.p. injection of the prodrug 7.09 [2].

High impact information on Arr3


Anatomical context of Arr3

  • AIM: To study the influence of carbamazepine (Car) on GABA effect in hippocampus [6].
  • CONCLUSION: Car facilitates the effects of GABA on pyramidal cells in hippocampal CA1 region, probably related to GABAB receptors [6].

Associations of Arr3 with chemical compounds

  • Bicuculline did not reverse Car facilitation on GABA inhibition on field potentials [6].
  • AIM: To study the effects of beta-carotene (Car) reducing the cardiotoxicity induced by doxorubicin (Dox) [7].

Analytical, diagnostic and therapeutic context of Arr3


  1. An evaluation of a polyamine-deficient diet for the treatment of inflammatory pain. Estebe, J.P., Legay, F., Gentili, M., Wodey, E., Leduc, C., Ecoffey, C., Moulinoux, J.P. Anesth. Analg. (2006) [Pubmed]
  2. Anti-inflammatory and ulcerogenic effects of 3-(N,N-diethylamino) propylindometacin HCl. Huang, Z.L., Kagoshima, M., Kagawa, E., Wang, W.Q., Shimada, H. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1997) [Pubmed]
  3. The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. Bhatnagar, A., Willins, D.L., Gray, J.A., Woods, J., Benovic, J.L., Roth, B.L. J. Biol. Chem. (2001) [Pubmed]
  4. Neuromodulator role of zinc and copper during prolonged ATP applications to P2X4 purinoceptors. Coddou, C., Morales, B., Huidobro-Toro, J.P. Eur. J. Pharmacol. (2003) [Pubmed]
  5. Comparative effects of cilazapril, carvedilol and their combination in preventing from left ventricular remodelling after acute myocardial infarction in rats. Yang, Y., Tang, Y., Ruan, Y., Li, Y., Zhou, Y., Gao, R., Chen, J., Chen, Z. Journal of the renin-angiotensin-aldosterone system : JRAAS. (2002) [Pubmed]
  6. Carbamazepine facilitates effects of GABA on rat hippocampus slices. Zhang, J.D., Saito, K. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1997) [Pubmed]
  7. Effects of beta-carotene on doxorubicin-induced cardiotoxicity in rats. Lü, H.Z., Geng, B.Q., Zhu, Y.L., Yong, D.G. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1996) [Pubmed]
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