Gene Review:
Pea15a - phosphoprotein enriched in astrocytes 15A
Mus musculus
Synonyms:
15 kDa phosphoprotein enriched in astrocytes, Astrocytic phosphoprotein PEA-15, Mat1, PEA-15, Pea15, ...
- The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15 kDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain. Sharif, A., Renault, F., Beuvon, F., Castellanos, R., Canton, B., Barbeito, L., Junier, M.P., Chneiweiss, H. Neuroscience (2004)
- Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction. Eramo, A., Pallini, R., Lotti, F., Sette, G., Patti, M., Bartucci, M., Ricci-Vitiani, L., Signore, M., Stassi, G., Larocca, L.M., Crinò, L., Peschle, C., De Maria, R. Cancer Res. (2005)
- PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase. Bartholomeusz, C., Gonzalez-Angulo, A.M., Kazansky, A., Krishnamurthy, S., Liu, P., Yuan, L.X., Yamasaki, F., Liu, S., Hayashi, N., Zhang, D., Esteva, F.J., Hortobagyi, G.N., Ueno, N.T. Clin. Cancer Res. (2010)
- Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. Hill, J.M., Vaidyanathan, H., Ramos, J.W., Ginsberg, M.H., Werner, M.H. EMBO J. (2002)
- Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism. Ramos, J.W., Hughes, P.E., Renshaw, M.W., Schwartz, M.A., Formstecher, E., Chneiweiss, H., Ginsberg, M.H. Mol. Biol. Cell (2000)
- The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Estellés, A., Charlton, C.A., Blau, H.M. Dev. Biol. (1999)
- Cellular expression, developmental regulation, and phylogenic conservation of PEA-15, the astrocytic major phosphoprotein and protein kinase C substrate. Danziger, N., Yokoyama, M., Jay, T., Cordier, J., Glowinski, J., Chneiweiss, H. J. Neurochem. (1995)
- Identification of a novel, alternatively spliced isoform and single nucleotide polymorphisms in the murine Pea-15 gene. Underhill, D.A., Vogan, K.J., Underhill, T.M., Gros, P. Mamm. Genome (2001)
- The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human. Estellés, A., Yokoyama, M., Nothias, F., Vincent, J.D., Glowinski, J., Vernier, P., Chneiweiss, H. J. Biol. Chem. (1996)
- Expression of MAT1/PEA-15 mRNA isoforms during physiological and neoplastic changes in the mouse mammary gland. Tsukamoto, T., Yoo, J., Hwang, S.I., Guzman, R.C., Hirokawa, Y., Chou, Y.C., Olatunde, S., Huang, T., Bera, T.K., Yang, J., Nandi, S. Cancer Lett. (2000)
- Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. Kitsberg, D., Formstecher, E., Fauquet, M., Kubes, M., Cordier, J., Canton, B., Pan, G., Rolli, M., Glowinski, J., Chneiweiss, H. J. Neurosci. (1999)