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Gene Review

Pea15a  -  phosphoprotein enriched in astrocytes 15A

Mus musculus

Synonyms: 15 kDa phosphoprotein enriched in astrocytes, Astrocytic phosphoprotein PEA-15, Mat1, PEA-15, Pea15, ...
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Disease relevance of Pea15a


High impact information on Pea15a


Biological context of Pea15a


Anatomical context of Pea15a

  • One such target, which we previously described, is PEA-15, a protein kinase C substrate associated with microtubules [9].
  • The 15-kDa phosphoprotein enriched in astrocytes (PEA-15) inhibits Fas-mediated apoptosis and increases tumor necrosis factor receptor-1 (TNF-R1)-mediated apoptosis in the same cell type in a ligand-dependent manner [6].
  • PEA-15 was found mainly in the cytosol, but its protein kinase C-phosphorylated form, Pb, was also detectable in association with the membrane and remained with the fraction that contains stabilized microtubules [7].
  • Expression of MAT1/PEA-15 mRNA isoforms during physiological and neoplastic changes in the mouse mammary gland [10].

Associations of Pea15a with chemical compounds

  • This led us to investigate if PEA-15 expression could be involved in astrocytic protection against deleterious effects of TNF [11].
  • Furthermore, PEA-15 expression leads to an increase in Ras guanosine 5'-triphosphate loading [5].

Other interactions of Pea15a


  1. The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15 kDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain. Sharif, A., Renault, F., Beuvon, F., Castellanos, R., Canton, B., Barbeito, L., Junier, M.P., Chneiweiss, H. Neuroscience (2004) [Pubmed]
  2. Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction. Eramo, A., Pallini, R., Lotti, F., Sette, G., Patti, M., Bartucci, M., Ricci-Vitiani, L., Signore, M., Stassi, G., Larocca, L.M., Crinò, L., Peschle, C., De Maria, R. Cancer Res. (2005) [Pubmed]
  3. PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase. Bartholomeusz, C., Gonzalez-Angulo, A.M., Kazansky, A., Krishnamurthy, S., Liu, P., Yuan, L.X., Yamasaki, F., Liu, S., Hayashi, N., Zhang, D., Esteva, F.J., Hortobagyi, G.N., Ueno, N.T. Clin. Cancer Res. (2010) [Pubmed]
  4. Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. Hill, J.M., Vaidyanathan, H., Ramos, J.W., Ginsberg, M.H., Werner, M.H. EMBO J. (2002) [Pubmed]
  5. Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism. Ramos, J.W., Hughes, P.E., Renshaw, M.W., Schwartz, M.A., Formstecher, E., Chneiweiss, H., Ginsberg, M.H. Mol. Biol. Cell (2000) [Pubmed]
  6. The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Estellés, A., Charlton, C.A., Blau, H.M. Dev. Biol. (1999) [Pubmed]
  7. Cellular expression, developmental regulation, and phylogenic conservation of PEA-15, the astrocytic major phosphoprotein and protein kinase C substrate. Danziger, N., Yokoyama, M., Jay, T., Cordier, J., Glowinski, J., Chneiweiss, H. J. Neurochem. (1995) [Pubmed]
  8. Identification of a novel, alternatively spliced isoform and single nucleotide polymorphisms in the murine Pea-15 gene. Underhill, D.A., Vogan, K.J., Underhill, T.M., Gros, P. Mamm. Genome (2001) [Pubmed]
  9. The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human. Estellés, A., Yokoyama, M., Nothias, F., Vincent, J.D., Glowinski, J., Vernier, P., Chneiweiss, H. J. Biol. Chem. (1996) [Pubmed]
  10. Expression of MAT1/PEA-15 mRNA isoforms during physiological and neoplastic changes in the mouse mammary gland. Tsukamoto, T., Yoo, J., Hwang, S.I., Guzman, R.C., Hirokawa, Y., Chou, Y.C., Olatunde, S., Huang, T., Bera, T.K., Yang, J., Nandi, S. Cancer Lett. (2000) [Pubmed]
  11. Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. Kitsberg, D., Formstecher, E., Fauquet, M., Kubes, M., Cordier, J., Canton, B., Pan, G., Rolli, M., Glowinski, J., Chneiweiss, H. J. Neurosci. (1999) [Pubmed]
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