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Gene Review

Nrgn  -  neurogranin

Mus musculus

Synonyms: 0710001B06Rik, AI838505, NG, NG/RC3, Neurogranin, ...
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Disease relevance of Nrgn


High impact information on Nrgn


Biological context of Nrgn


Anatomical context of Nrgn


Associations of Nrgn with chemical compounds


Regulatory relationships of Nrgn

  • These results suggest that by its Ca2+-sensitive CaM-binding feature, and through its phosphorylation and oxidation, Ng regulates the Ca2+- and Ca2+/CaM-dependent signaling pathways subsequent to the stimulation of NMDA receptor [17].

Other interactions of Nrgn


Analytical, diagnostic and therapeutic context of Nrgn


  1. Protein kinase C and its substrates in tumor promoter-sensitive and -resistant cells. Smith, B.M., Colburn, N.H. J. Biol. Chem. (1988) [Pubmed]
  2. Transthyretin regulates thyroid hormone levels in the choroid plexus, but not in the brain parenchyma: study in a transthyretin-null mouse model. Palha, J.A., Fernandes, R., de Escobar, G.M., Episkopou, V., Gottesman, M., Saraiva, M.J. Endocrinology (2000) [Pubmed]
  3. Dissociation of phosphorylation and translocation of a myristoylated protein kinase C substrate (MARCKS protein) in C6 glioma and N1E-115 neuroblastoma cells. Byers, D.M., Palmer, F.B., Spence, M.W., Cook, H.W. J. Neurochem. (1993) [Pubmed]
  4. Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts. Wolfman, A., Macara, I.G. Nature (1987) [Pubmed]
  5. A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation. Lehväslaiho, H., Lehtola, L., Sistonen, L., Alitalo, K. EMBO J. (1989) [Pubmed]
  6. Enhanced learning after genetic overexpression of a brain growth protein. Routtenberg, A., Cantallops, I., Zaffuto, S., Serrano, P., Namgung, U. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice. Pak, J.H., Huang, F.L., Li, J., Balschun, D., Reymann, K.G., Chiang, C., Westphal, H., Huang, K.P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  8. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse. Wu, J., Li, J., Huang, K.P., Huang, F.L. J. Biol. Chem. (2002) [Pubmed]
  9. Calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3. van Dalen, J.J., Gerendasy, D.D., de Graan, P.N., Schrama, L.H., Gruol, D.L. Eur. J. Neurosci. (2003) [Pubmed]
  10. Neurogranin expression by cerebellar neurons in rodents and non-human primates. Singec, I., Knoth, R., Ditter, M., Frotscher, M., Volk, B. J. Comp. Neurol. (2003) [Pubmed]
  11. Neurogranin is expressed by principal cells but not interneurons in the rodent and monkey neocortex and hippocampus. Singec, I., Knoth, R., Ditter, M., Volk, B., Frotscher, M. J. Comp. Neurol. (2004) [Pubmed]
  12. Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells. Rosé, S.D., Cook, H.W., Palmer, F.B., Ridgway, N.D., Byers, D.M. J. Neurochem. (1994) [Pubmed]
  13. Neurogranin expression identifies a novel array of Purkinje cell parasagittal stripes during mouse cerebellar development. Larouche, M., Che, P.M., Hawkes, R. J. Comp. Neurol. (2006) [Pubmed]
  14. Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor alpha. Wilcoxon, J.S., Nadolski, G.J., Samarut, J., Chassande, O., Redei, E.E. Behav. Brain Res. (2007) [Pubmed]
  15. Age-related effects of ethanol consumption on triiodothyronine and retinoic acid nuclear receptors, neurogranin and neuromodulin expression levels in mouse brain. Boucheron, C., Alfos, S., Enderlin, V., Husson, M., Pallet, V., Jaffard, R., Higueret, P. Neurobiol. Aging (2006) [Pubmed]
  16. Substrate phosphorylation in the protein kinase Cgamma knockout mouse. Ramakers, G.M., Gerendasy, D.D., de Graan, P.N. J. Biol. Chem. (1999) [Pubmed]
  17. Participation of NMDA-mediated phosphorylation and oxidation of neurogranin in the regulation of Ca2+- and Ca2+/calmodulin-dependent neuronal signaling in the hippocampus. Wu, J., Huang, K.P., Huang, F.L. J. Neurochem. (2003) [Pubmed]
  18. Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein. Baudier, J., Delphin, C., Grunwald, D., Khochbin, S., Lawrence, J.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  19. SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)-->S progression by controlling the expression and cellular compartmentalization of cyclin D. Lin, X., Nelson, P., Gelman, I.H. Mol. Cell. Biol. (2000) [Pubmed]
  20. Pentylenetetrazole-induced chemoshock affects protein kinase C and substrate proteins in mouse brain. Chen, C.C. J. Neurochem. (1994) [Pubmed]
  21. Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia. Chang, J.W., Schumacher, E., Coulter, P.M., Vinters, H.V., Watson, J.B. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  22. Altered levels and protein kinase C-mediated phosphorylation of substrates in normal and transformed mouse lung epithelial cells. Morris, C.M., Smith, G.J. Exp. Cell Res. (1992) [Pubmed]
  23. Heterogeneity of glycinergic and gabaergic interneurons in the granule cell layer of mouse cerebellum. Simat, M., Parpan, F., Fritschy, J.M. J. Comp. Neurol. (2007) [Pubmed]
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