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Pitpna  -  phosphatidylinositol transfer protein, alpha

Mus musculus

Synonyms: PI-TP-alpha, Phosphatidylinositol transfer protein alpha isoform, Pitp alpha, Pitpn, PtdIns transfer protein alpha, ...
 
 
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Disease relevance of Pitpna

 

High impact information on Pitpna

  • Phosphatidylinositol transfer protein alpha (PITP alpha) is a ubiquitous and highly conserved protein in multicellular eukaryotes that catalyzes the exchange of phospholipids between membranes in vitro and participates in cellular phospholipid metabolism, signal transduction and vesicular trafficking in vivo [2].
  • Taken together, the data suggest an unanticipated role for PITP alpha in with glucose homeostasis and in mammalian endoplasmic reticulum functions that interface with transport of specific luminal lipid cargoes [1].
  • By this novel method it was found that PI-TP beta was preferentially associated with perinuclear membrane structures whereas PI-TP alpha was predominantly present in the nucleus and in the cytoplasm [3].
  • The PI-TP alpha and PI-TP beta used were purified from bovine brain cytosol and covalently labeled with sulfoindocyanine dyes [3].
  • The influence of ethanol and membrane curvature on the activity of recombinant mouse PITP-alpha in vitro is evaluated by monitoring the transfer of phosphatidylinositol (PtdIns) from rat hepatic microsomes to unilamellar vesicles [4].
 

Biological context of Pitpna

  • Vibrator (gene symbol vb), an autosomal recessive mutation, occurred spontaneously in the DBA/2J strain of mice, was rescued by a single cross to C57BL/6J and subsequent brother X sister mating, and has been mapped near shaker-2 (sh-2) and vestigial tail (vt) on chromosome 11 [5].
 

Anatomical context of Pitpna

 

Associations of Pitpna with chemical compounds

 

Analytical, diagnostic and therapeutic context of Pitpna

References

  1. Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia. Alb, J.G., Cortese, J.D., Phillips, S.E., Albin, R.L., Nagy, T.R., Hamilton, B.A., Bankaitis, V.A. J. Biol. Chem. (2003) [Pubmed]
  2. Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association. Schouten, A., Agianian, B., Westerman, J., Kroon, J., Wirtz, K.W., Gros, P. EMBO J. (2002) [Pubmed]
  3. Fluorescently labeled phosphatidylinositol transfer protein isoforms (alpha and beta), microinjected into fetal bovine heart endothelial cells, are targeted to distinct intracellular sites. De Vries, K.J., Westerman, J., Bastiaens, P.I., Jovin, T.M., Wirtz, K.W., Snoek, G.T. Exp. Cell Res. (1996) [Pubmed]
  4. Activity of phosphatidylinositol transfer protein is sensitive to ethanol and membrane curvature. Komatsu, H., Bouma, B., Wirtz, K.W., Taraschi, T.F., Janes, N. Biochem. J. (2000) [Pubmed]
  5. Vibrator (vb): a spinocerebellar system degeneration with autosomal recessive inheritance in mice. Weimar, W.R., Lane, P.W., Sidman, R.L. Brain Res. (1982) [Pubmed]
  6. Lipid metabolism in phosphatidylinositol transfer protein alpha-deficient vibrator mice. Monaco, M.E., Kim, J., Ruan, W., Wieczorek, R., Kleinberg, D.L., Walden, P.D. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  7. Phosphoinositide signalling in nuclei of Friend cells: DMSO-induced differentiation reduces the association of phosphatidylinositol-transfer protein with the nucleus. Rubbini, S., Cocco, L., Manzoli, L., Lutterman, J., Billi, A.M., Matteucci, A., Wirtz, K.W. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
 
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