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Gene Review

E4F1  -  E4F transcription factor 1

Homo sapiens

Synonyms: E4F, Transcription factor E4F, Transcription factor E4F1, p120E4F, p50E4F
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Disease relevance of E4F1


High impact information on E4F1


Biological context of E4F1

  • E4F1, a possible inducer of cell growth arrest, was markedly increased only in ER alpha-positive VSMCs by estrogens in both microarray and RT-PCR analyses [5].
  • Collectively, our data reveal that E4F1 is a key posttranslational regulator of p53, which modulates its effector functions involved in alternative cell fates: growth arrest or apoptosis [2].
  • These and other results suggest that the E4 promoter may be comprised solely of multiple E4F1 binding sites and a TATA box [1].
  • A cellular transcription factor E4F1 interacts with an E1a-inducible enhancer and mediates constitutive enhancer function in vitro [1].
  • Mouse embryos lacking E4F die at an early developmental stage, whereas enforced expression of E4F1 in various cell lines inhibits cell cycle progression [6].

Anatomical context of E4F1


Associations of E4F1 with chemical compounds


Regulatory relationships of E4F1


Other interactions of E4F1

  • E4F1 is therefore considered one of the estrogen-responsive genes involving ER alpha-mediated inhibition of VSMC proliferation and may play an important role in estrogen-related atheroprotection of human aorta [5].

Analytical, diagnostic and therapeutic context of E4F1


  1. A cellular transcription factor E4F1 interacts with an E1a-inducible enhancer and mediates constitutive enhancer function in vitro. Lee, K.A., Green, M.R. EMBO J. (1987) [Pubmed]
  2. E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation. Le Cam, L., Linares, L.K., Paul, C., Julien, E., Lacroix, M., Hatchi, E., Triboulet, R., Bossis, G., Shmueli, A., Rodriguez, M.S., Coux, O., Sardet, C. Cell (2006) [Pubmed]
  3. E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells. Chagraoui, J., Niessen, S.L., Lessard, J., Girard, S., Coulombe, P., Sauvageau, M., Meloche, S., Sauvageau, G. Genes Dev. (2006) [Pubmed]
  4. DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation. Raychaudhuri, P., Bagchi, S., Nevins, J.R. Genes Dev. (1989) [Pubmed]
  5. E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. Nakamura, Y., Igarashi, K., Suzuki, T., Kanno, J., Inoue, T., Tazawa, C., Saruta, M., Ando, T., Moriyama, N., Furukawa, T., Ono, M., Moriya, T., Ito, K., Saito, H., Ishibashi, T., Takahashi, S., Yamada, S., Sasano, H. Am. J. Pathol. (2004) [Pubmed]
  6. The LIM-only protein FHL2 is a negative regulator of E4F1. Paul, C., Lacroix, M., Iankova, I., Julien, E., Schäfer, B.W., Labalette, C., Wei, Y., Le Cam, A., Le Cam, L., Sardet, C. Oncogene (2006) [Pubmed]
  7. Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids. Saccone, S., Sandy, P., Meroni, G., Gostissa, M., Della Valle, G., Del Sal, G. Cytogenet. Cell Genet. (1998) [Pubmed]
  8. The carboxy-terminal exon of the adenovirus E1A protein is required for E4F-dependent transcription activation. Bondesson, M., Svensson, C., Linder, S., Akusjärvi, G. EMBO J. (1992) [Pubmed]
  9. The E4F protein is required for mitotic progression during embryonic cell cycles. Le Cam, L., Lacroix, M., Ciemerych, M.A., Sardet, C., Sicinski, P. Mol. Cell. Biol. (2004) [Pubmed]
  10. Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein. Colombo, R., Draetta, G.F., Chiocca, S. Oncogene (2003) [Pubmed]
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