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Gene Review

Plb1  -  phospholipase B1

Rattus norvegicus

Synonyms: PLB/LIP, Phlpb, Phospholipase B, Phospholipase B/lipase, Phospholipase B1, membrane-associated
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Disease relevance of Phlpb


High impact information on Phlpb


Biological context of Phlpb


Anatomical context of Phlpb

  • Phospholipase B in the brains and meninges of nonsensitized and sensitized rats after challenge with Angiostrongylus cantonensis [6].
  • PLA2, as well as phospholipase C (PLC), treatment of synaptic membranes produced a dose-dependent increase in the specific binding of [3H]HCh-3 whereas neither phospholipase B nor phospholipase D had any effect [7].
  • We propose that PLB secreted by cryptococci promotes tissue invasion by hydrolysing host phospholipids, such as dipalmitoyl phosphatidyl choline, which is abundant in pulmonary surfactant, and lung cell membrane phospholipids [5].
  • A uniform value of activity per cell was found in all these tissues extending previous histochemical and biochemical evidence that the eosinophil is the carrier cell for the phospholipase B to all major sites of distribution [8].

Associations of Phlpb with chemical compounds


Analytical, diagnostic and therapeutic context of Phlpb


  1. Purification and characterization of a catalytic domain of rat intestinal phospholipase B/lipase associated with brush border membranes. Tojo, H., Ichida, T., Okamoto, M. J. Biol. Chem. (1998) [Pubmed]
  2. Increased intestinal phospholipase A(2) activity catalyzed by phospholipase B/lipase in WBN/Kob rats with pancreatic insufficiency. Tchoua, U., Ito, M., Okamoto, M., Tojo, H. Biochim. Biophys. Acta (2000) [Pubmed]
  3. Identification of functional domains of rat intestinal phospholipase B/lipase. Its cDNA cloning, expression, and tissue distribution. Takemori, H., Zolotaryov, F.N., Ting, L., Urbain, T., Komatsubara, T., Hatano, O., Okamoto, M., Tojo, H. J. Biol. Chem. (1998) [Pubmed]
  4. Purification and partial characterization of a retinyl ester hydrolase from the brush border of rat small intestine mucosa: probable identity with brush border phospholipase B. Rigtrup, K.M., Kakkad, B., Ong, D.E. Biochemistry (1994) [Pubmed]
  5. Identification of metabolites of importance in the pathogenesis of pulmonary cryptococcoma using nuclear magnetic resonance spectroscopy. Himmelreich, U., Allen, C., Dowd, S., Malik, R., Shehan, B.P., Mountford, C., Sorrell, T.C. Microbes Infect. (2003) [Pubmed]
  6. Phospholipase B in the brains and meninges of nonsensitized and sensitized rats after challenge with Angiostrongylus cantonensis. Ottolenghi, A., Weatherly, N.F., Larsh, J.E. Infect. Immun. (1980) [Pubmed]
  7. Specificity of the activation of [3H]hemicholinium-3 binding by phospholipase A2. Yamada, K., Saltarelli, M.D., Coyle, J.T. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  8. Eosinophilic leucocytes and phospholipase B of rat tissues. Ottolenghi, A. Cell and tissue kinetics. (1986) [Pubmed]
  9. Further characterization of a novel phospholipase B (phospholipase A2--lysophospholipase) from intestinal brush-border membranes. Pind, S., Kuksis, A. Biochem. Cell Biol. (1991) [Pubmed]
  10. Differential modulation of cell recruitment and acute edema in a model of Polybia paulista venom-induced inflammation. de Paula, L., Santos, W.F., Malheiro, A., Carlos, D., Faccioli, L.H. Int. Immunopharmacol. (2006) [Pubmed]
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