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Gene Review

Rbp2  -  retinol binding protein 2, cellular

Mus musculus

Synonyms: CRBP-II, Cellular retinol-binding protein II, Crbp-2, CrbpII, Crbpii, ...
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High impact information on Rbp2

  • Driven by the suprabasal-specific keratin-10 gene promoter, expression of dnRXR alpha severely reduced the ability of RAR-selective ligands tRA and CD367 to induce epidermal mRNA levels of the CRABPII, CRBPI, and CRBPII genes, which contain RA-responsive elements (RAREs) DR1 and/or DR2 [1].
  • Using the mouse CRBPII promoter as a reporter gene, we now report that the AB regions of RAR alpha, beta and gamma, as well as those of RXR alpha and gamma, contain an autonomous, ligand-independent activation function, AF-1, which can efficiently synergize with AF-2s [2].
  • Cellular retinol-binding protein II (CRBP II) is a member of the cellular retinol-binding protein family, which is expressed primarily in the small intestine [3].
  • The saturable component of intestinal retinol uptake is impaired in CRBP II(-/-) mice [3].
  • Maternal CRBP II was localized by immunostaining in the placenta at 18 days postcoitum as well as in the small intestine [3].

Biological context of Rbp2

  • We show here that the element which was previously characterized as a retinoid X receptor (RXR)-specific response element (RXRE) in the rat cellular retinol-binding protein II (CRBPII) gene is not conserved in the mouse gene [4].
  • However, two conserved cis-acting elements (RE2 and RE3) located in the promoter region of the mouse and rat CRBPII genes mediate transactivation by retinoic acid receptors (RARs) and RXRs in transfected Cos-1, CV-1, and HeLa cells [4].
  • Expression of the cellular retinoic acid binding protein I (CRABPI) is restricted during development in Kölliker's organ whilst cellular retinol binding protein II (CRBPII) is only visible after birth with a ubiquitous distribution in most regions of the cochlea including nervous components [5].
  • Transient transfection assays performed in NIH 3T3 fibroblast cells demonstrated that RXR alpha yielded a high level of 9cRA-dependent transcription of a reporter gene linked to the CRBP II enhancer, when compared with RXR beta [6].
  • However, reducing maternal dietary vitamin A to marginal levels during the latter half of gestation results in 100% mortality/litter within 24 h after birth in the CRBP II(-/-) line but no mortality in the wild type line [3].

Anatomical context of Rbp2


Associations of Rbp2 with chemical compounds


Physical interactions of Rbp2


Other interactions of Rbp2


  1. Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids. Feng, X., Peng, Z.H., Di, W., Li, X.Y., Rochette-Egly, C., Chambon, P., Voorhees, J.J., Xiao, J.H. Genes Dev. (1997) [Pubmed]
  2. RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo. Nagpal, S., Friant, S., Nakshatri, H., Chambon, P. EMBO J. (1993) [Pubmed]
  3. Increased neonatal mortality in mice lacking cellular retinol-binding protein II. E, X., Zhang, L., Lu, J., Tso, P., Blaner, W.S., Levin, M.S., Li, E. J. Biol. Chem. (2002) [Pubmed]
  4. The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers. Nakshatri, H., Chambon, P. J. Biol. Chem. (1994) [Pubmed]
  5. Spatio-temporal distribution of cellular retinoid binding protein gene transcripts in the developing and the adult cochlea. Morphological and functional consequences in CRABP- and CRBPI-null mutant mice. Romand, R., Sapin, V., Ghyselinck, N.B., Avan, P., Le Calvez, S., Dollé, P., Chambon, P., Mark, M. Eur. J. Neurosci. (2000) [Pubmed]
  6. Differential 9-cis-retinoic acid-dependent transcriptional activation by murine retinoid X receptor alpha (RXR alpha) and RXR beta. Role of cell type and RXR domains. Hallenbeck, P.L., Minucci, S., Lippoldt, R., Phyillaier, M., Horn, V., Ozato, K., Nikodem, V.M. J. Biol. Chem. (1996) [Pubmed]
  7. Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Sapin, V., Ward, S.J., Bronner, S., Chambon, P., Dollé, P. Dev. Dyn. (1997) [Pubmed]
  8. Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol. Vogel, S., Mendelsohn, C.L., Mertz, J.R., Piantedosi, R., Waldburger, C., Gottesman, M.E., Blaner, W.S. J. Biol. Chem. (2001) [Pubmed]
  9. Temporal/spatial expression of retinoid binding proteins and RAR isoforms in the postnatal lung. Hind, M., Corcoran, J., Maden, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  10. Folding mechanism of three structurally similar beta-sheet proteins. Burns, L.L., Dalessio, P.M., Ropson, I.J. Proteins (1998) [Pubmed]
  11. Microsomal triglyceride transfer protein expression in mouse intestine. Swift, L.L., Jovanovska, A., Kakkad, B., Ong, D.E. Histochem. Cell Biol. (2005) [Pubmed]
  12. Correlations of RAR isoforms and cellular retinoid-binding proteins mRNA levels with retinoid-induced teratogenesis. Soprano, D.R., Harnish, D.C., Soprano, K.J., Kochhar, D.M., Jiang, H. J. Nutr. (1993) [Pubmed]
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