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Gene Review

Fabp2  -  fatty acid binding protein 2, intestinal

Mus musculus

Synonyms: Fabpi, Fatty acid-binding protein 2, Fatty acid-binding protein, intestinal, I-FABP, Intestinal-type fatty acid-binding protein
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Disease relevance of Fabp2


High impact information on Fabp2


Biological context of Fabp2


Anatomical context of Fabp2

  • In addition, Fabpi expression in enterocytes was examined as a function of their differentiation along the crypto-to-villus and duodenal-to-colonic axes of the small intestine [5].
  • The rat intestinal fatty acid binding protein (I-FABP) gene has been used as a model to study temporal and spatial differentiation of the gut epithelium while its protein product has been used as a model for examining the atomic details of noncovalent fatty acid-protein interactions [5].
  • SV40 large T antigen (TAg(Wt)) or a mutant derivative (TAg(K107/8)) that does not bind pRB was expressed in small intestinal villus enterocytes under the control of elements from the intestinal fatty acid binding protein gene (Fabpi) [7].
  • However, other I-FABP/hGH fusion genes that exhibit differentiation-dependent changes in their expression along the crypt-to-villus axis do not manifest the same pattern of differentiation-dependent change in activity in this cell line [8].
  • We have compared and contrasted the transcriptional activity of four fusion genes composed of elements from the 5'-nontranscribed domain of rat Fabpi linked to the human growth hormone gene (I-FABP/hGH) in transgenic mice and in five primate epithelial cell lines derived from intestine, liver, kidney, and cervix [8].

Associations of Fabp2 with chemical compounds

  • Finally, predictions of the structure of mouse I-FABP using the refined 2.0 A model of rat I-FABP, suggest that a proline found at position 69 of the mouse, but not rat, protein may affect its ligand binding properties [5].
  • I-FABP deficiency had no effect on glucose tolerance in male mice but it appeared to be improved in female mice [2].
  • Surprisingly, both L- and I-FABP expression increased ethanolamine plasmalogen mass 1.6- and 1.1-fold, respectively, while choline plasmalogen mass was increased 2.3- and 1.7-fold, respectively [9].
  • In contrast, I-FABP expression only increased the masses of ChoGpl and PtdSer, 1.2- and 3.1-fold, respectively [9].
  • Although, the initial [3H]oleic acid esterification into total phospholipids was unchanged, within the phospholipid fraction the initial [3H]oleic acid esterification into phosphatidylethanolamine was increased 70% and decreased 50% in phosphatidylcholine in I-FABP expressing cells [10].

Other interactions of Fabp2

  • The results indicate that both L-FABP and ilbp levels are modestly increased in the small intestine of chow-fed mice lacking I-FABP [2].
  • Finally, the proximal intestine also expresses intestinal-FABP (I-FABP) which decreased 3-fold in the TGF beta 1-deficient/immunodeficient C3H mice only [11].
  • The increase in phospholipid levels resulted in dramatic 48 and 33% decreases in the cholesterol-to-phospholipid ratio in L- and I-FABP expressing cells, respectively [9].

Analytical, diagnostic and therapeutic context of Fabp2


  1. The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice. Vassileva, G., Huwyler, L., Poirier, K., Agellon, L.B., Toth, M.J. FASEB J. (2000) [Pubmed]
  2. Adaptations to the loss of intestinal fatty acid binding protein in mice. Agellon, L.B., Li, L., Luong, L., Uwiera, R.R. Mol. Cell. Biochem. (2006) [Pubmed]
  3. A 20-nucleotide element in the intestinal fatty acid binding protein gene modulates its cell lineage-specific, differentiation-dependent, and cephalocaudal patterns of expression in transgenic mice. Simon, T.C., Roberts, L.J., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Cellular differentiation in the emerging fetal rat small intestinal epithelium: mosaic patterns of gene expression. Rubin, D.C., Ong, D.E., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. The mouse intestinal fatty acid binding protein gene: nucleotide sequence, pattern of developmental and regional expression, and proposed structure of its protein product. Green, R.P., Cohn, S.M., Sacchettini, J.C., Jackson, K.E., Gordon, J.I. DNA Cell Biol. (1992) [Pubmed]
  6. Nucleotide sequence of a cDNA clone coding for an intestinal-type fatty acid binding protein and its tissue-specific expression in zebrafish (Danio rerio). Pierce, M., Wang, Y., Denovan-Wright, E.M., Wright, J.M. Biochim. Biophys. Acta (2000) [Pubmed]
  7. A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes. Mysorekar, I.U., Lorenz, R.G., Gordon, J.I. J. Biol. Chem. (2002) [Pubmed]
  8. Comparison of the patterns of expression of rat intestinal fatty acid binding protein/human growth hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic mice. Rottman, J.N., Gordon, J.I. J. Biol. Chem. (1993) [Pubmed]
  9. Liver and intestinal fatty acid-binding protein expression increases phospholipid content and alters phospholipid fatty acid composition in L-cell fibroblasts. Murphy, E.J., Prows, D.R., Stiles, T., Schroeder, F. Lipids (2000) [Pubmed]
  10. Intestinal fatty acid-binding protein expression stimulates fibroblast fatty acid esterification. Prows, D.R., Murphy, E.J., Moncecchi, D., Schroeder, F. Chem. Phys. Lipids (1996) [Pubmed]
  11. Liver and intestinal fatty acid binding proteins in control and TGF beta 1 gene targeted deficient mice. Fontaine, R.N., Gossett, R.E., Schroeder, F., O'Toole, B.A., Doetschman, T., Kier, A.B. Mol. Cell. Biochem. (1996) [Pubmed]
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