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Gene Review

Rbp1  -  retinol binding protein 1, cellular

Mus musculus

Synonyms: CRBP, CRBP-I, CRBPI, Cellular retinol-binding protein, Cellular retinol-binding protein I, ...
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Disease relevance of Rbp1


High impact information on Rbp1


Biological context of Rbp1


Anatomical context of Rbp1

  • The RARbeta2gamma2 retinal pigment epithelium (RPE) cells display histological and/or ultrastructural alterations and/or fail to express cellular retinol binding protein I (CRBPI) [10].
  • It is therefore unlikely that CRABPs and CRBPI are directly involved in development of the cochlea and hair cell differentiation [11].
  • The caudate/putamen of the developing brain showed strong CRBP I-IR in a compartmentalized manner, while at the same time containing many evenly distributed CRABP I-IR neurons [12].
  • Morphological observations of CRBPI- and CRABPI/CRABPII-null mutant fetus at 18.5 dpc do not show any structural modification at the level of the organ of Corti [11].
  • (iii) In the craniofacial region, CRABP transcripts were found in the mesenchyme of the frontonasal mass and mandible, while CRBP transcripts were found in the mesenchyme of the nasolachrymal duct and surrounding the auditory vesicle [8].

Associations of Rbp1 with chemical compounds

  • A specific cis-acting element responsible for retinoic acid (RA) inducibility of the mCRBPI promoter was identified and characterized [6].
  • The control of CRBPI gene transcription by RA-RAR complexes interacting with the RARE characterized here may correspond to a feedback mechanism important in regulating retinoid metabolism and action [6].
  • Interestingly, the expression of the three genes, RAR-beta, CRABP II and CRBP I, is induced by retinoic acid, which suggests a link between the synthesis of RA from retinol and the control of expression of subsets of RA-responsive genes [13].
  • 3) Induction of CRABP mRNA by RA was blocked by the protein synthesis inhibitor cycloheximide, whereas induction of CRBP mRNA was not [14].
  • Western analysis revealed that CRBP protein was elevated 3.2-fold (p < 0.01, n = 6) and 3.0-fold (p < 0.01, n = 6) after all-trans retinoic acid treatment of human skin in vivo for 24 and 96 h, respectively, compared with vehicle- and sodium lauryl sulfate-treated skin [15].

Physical interactions of Rbp1


Regulatory relationships of Rbp1


Other interactions of Rbp1


Analytical, diagnostic and therapeutic context of Rbp1


  1. Cellular retinol-binding protein I is essential for vitamin A homeostasis. Ghyselinck, N.B., Båvik, C., Sapin, V., Mark, M., Bonnier, D., Hindelang, C., Dierich, A., Nilsson, C.B., Håkansson, H., Sauvant, P., Azaïs-Braesco, V., Frasson, M., Picaud, S., Chambon, P. EMBO J. (1999) [Pubmed]
  2. Effect of malignant transformation upon the cellular retinoid binding proteins in cultured murine mammary cells. Bunk, M.J., Telang, N.T., Sarkar, N.H. Cancer Lett. (1983) [Pubmed]
  3. Saturation analysis of cellular retinoid binding proteins: application to retinoic acid resistant human neuroblastoma cells and to human tumors. Kelly, M.A., Sidell, N., Haussler, M.R. Biochem. Cell Biol. (1987) [Pubmed]
  4. Retinoids and tumorigenesis: mechanistic considerations. De Luca, L.M. Medical oncology and tumor pharmacotherapy. (1985) [Pubmed]
  5. Comparison of the level of cellular retinoid-binding proteins and susceptibility to retinoid-induced growth inhibition of various neoplastic cell lines. Lotan, R., Ong, D.E., Chytil, F. J. Natl. Cancer Inst. (1980) [Pubmed]
  6. A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter. Smith, W.C., Nakshatri, H., Leroy, P., Rees, J., Chambon, P. EMBO J. (1991) [Pubmed]
  7. Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development. Ruberte, E., Friederich, V., Chambon, P., Morriss-Kay, G. Development (1993) [Pubmed]
  8. Spatial and temporal pattern of expression of the cellular retinoic acid-binding protein and the cellular retinol-binding protein during mouse embryogenesis. Perez-Castro, A.V., Toth-Rogler, L.E., Wei, L.N., Nguyen-Huu, M.C. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  9. Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Dollé, P., Ruberte, E., Leroy, P., Morriss-Kay, G., Chambon, P. Development (1990) [Pubmed]
  10. Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice. Grondona, J.M., Kastner, P., Gansmuller, A., Décimo, D., Chambon, P., Mark, M. Development (1996) [Pubmed]
  11. Spatio-temporal distribution of cellular retinoid binding protein gene transcripts in the developing and the adult cochlea. Morphological and functional consequences in CRABP- and CRBPI-null mutant mice. Romand, R., Sapin, V., Ghyselinck, N.B., Avan, P., Le Calvez, S., Dollé, P., Chambon, P., Mark, M. Eur. J. Neurosci. (2000) [Pubmed]
  12. Role of retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid. Zetterström, R.H., Lindqvist, E., Mata de Urquiza, A., Tomac, A., Eriksson, U., Perlmann, T., Olson, L. Eur. J. Neurosci. (1999) [Pubmed]
  13. Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis. Ruberte, E., Friederich, V., Morriss-Kay, G., Chambon, P. Development (1992) [Pubmed]
  14. Regulation of the cellular retinoid-binding proteins and their messenger ribonucleic acids during P19 embryonal carcinoma cell differentiation induced by retinoic acid. Wei, L.N., Blaner, W.S., Goodman, D.S., Nguyen-Huu, M.C. Mol. Endocrinol. (1989) [Pubmed]
  15. All-trans retinoic acid induces cellular retinol-binding protein in human skin in vivo. Fisher, G.J., Reddy, A.P., Datta, S.C., Kang, S., Yi, J.Y., Chambon, P., Voorhees, J.J. J. Invest. Dermatol. (1995) [Pubmed]
  16. Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Sapin, V., Ward, S.J., Bronner, S., Chambon, P., Dollé, P. Dev. Dyn. (1997) [Pubmed]
  17. Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo. Gustafson, A.L., Dencker, L., Eriksson, U. Development (1993) [Pubmed]
  18. A retinoic acid response element from the rat CRBPI promoter is activated by an RAR/RXR heterodimer. Husmann, M., Hoffmann, B., Stump, D.G., Chytil, F., Pfahl, M. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  19. CRBP I and CRABP I localisation during olfactory nerve development. Gustafson, A.L., Eriksson, U., Dencker, L. Brain Res. Dev. Brain Res. (1999) [Pubmed]
  20. Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation. Molotkov, A., Ghyselinck, N.B., Chambon, P., Duester, G. Biochem. J. (2004) [Pubmed]
  21. The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers. Nakshatri, H., Chambon, P. J. Biol. Chem. (1994) [Pubmed]
  22. The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. Demmer, L.A., Birkenmeier, E.H., Sweetser, D.A., Levin, M.S., Zollman, S., Sparkes, R.S., Mohandas, T., Lusis, A.J., Gordon, J.I. J. Biol. Chem. (1987) [Pubmed]
  23. Cellular retinoic acid binding protein is associated with mitochondria. Ruff, S.J., Ong, D.E. FEBS Lett. (2000) [Pubmed]
  24. Retinoid-binding proteins are phosphorylated in vitro by soluble Ca+2- and phosphatidylserine-dependent protein kinase from mouse brain. Cope, F.O., Staller, J.M., Mahsem, R.A., Boutwell, R.K. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
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