The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Crabp1  -  cellular retinoic acid binding protein I

Mus musculus

Synonyms: AI326249, CRABP-I, Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, Crabp-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Crabp1


High impact information on Crabp1


Chemical compound and disease context of Crabp1


Biological context of Crabp1

  • Both CRABP transcripts are present in embryonic structures from the earliest stages studied and exhibit specific patterns of distribution, suggesting that the two retinoic acid (RA) binding proteins perform different functions during mouse embryogenesis [13].
  • The transcript distribution of CRABP I and II is discussed in relation to the teratogenic effects of RA, and compared to the RA-sensitive pattern of expression of other important developmental genes [13].
  • Expression of the cellular retinoic acid binding protein I (CRABPI) is restricted during development in Kölliker's organ whilst cellular retinol binding protein II (CRBPII) is only visible after birth with a ubiquitous distribution in most regions of the cochlea including nervous components [14].
  • Throughout placentation, the expression patterns of the CRABP I and II genes partly overlap in the decidual tissue and the vacuolar zones of the decidua, suggesting a role for these binding proteins in sequestering free retinoic acid from maternal blood, thus regulating its availability to the embryo [15].
  • A role of thyroid hormones in CRABP-I gene expression and vitamin A metabolism in animals is discussed [1].

Anatomical context of Crabp1


Associations of Crabp1 with chemical compounds


Physical interactions of Crabp1

  • We have previously shown that both transforming growth factor-beta (TGF-beta) and retinoic acid (RA) regulate the expression of cellular retinoic acid binding proteins (CRABP) I and II and TGF-beta 3 mRNAs in primary cultures of murine embryonic palate mesenchymal (MEPM) cells [22].

Regulatory relationships of Crabp1

  • Furthermore, heat- or acid-activated CM also inhibited CRABP-I and RA-induced RAR-beta expression [22].
  • Antisense oligonucleotides to CRABP-I partially inhibited the RA-induced TGF-beta 3, RAR-beta, and tenascin mRNA expression [21].
  • Most mesenchymal cells of the limbs and craniofacial structures did not express detectable levels of CRBP I but instead expressed cellular retinoic acid-binding protein I (CRABP I) [23].
  • However, BMP-2 down-regulated CRABP I message without affecting message stability [24].
  • Stably transfected lines expressing elevated levels of CRABP-I exhibit an 80-90% reduction in the RA induced expression of retinoic acid receptor (RAR) beta, laminin B1, and collagen type IV (alpha 1) mRNAs at low exogenous RA concentrations, but this reduction is eliminated at higher RA concentrations [25].

Other interactions of Crabp1


Analytical, diagnostic and therapeutic context of Crabp1


  1. Regulation of the mouse cellular retinoic acid-binding protein-I gene by thyroid hormone and retinoids in transgenic mouse embryos and P19 cells. Wei, L.N., Lee, C.H., Filipcik, P., Chang, L. J. Endocrinol. (1997) [Pubmed]
  2. Mouse cellular retinoic acid binding protein: cloning, complementary DNA sequence, and messenger RNA expression during the retinoic acid-induced differentiation of F9 wild type and RA-3-10 mutant teratocarcinoma cells. Stoner, C.M., Gudas, L.J. Cancer Res. (1989) [Pubmed]
  3. Comparison of the level of cellular retinoid-binding proteins and susceptibility to retinoid-induced growth inhibition of various neoplastic cell lines. Lotan, R., Ong, D.E., Chytil, F. J. Natl. Cancer Inst. (1980) [Pubmed]
  4. Defective lens fiber differentiation and pancreatic tumorigenesis caused by ectopic expression of the cellular retinoic acid-binding protein I. Perez-Castro, A.V., Tran, V.T., Nguyen-Huu, M.C. Development (1993) [Pubmed]
  5. Changing patterns of the retinoic acid system in the developing retina. McCaffrery, P., Posch, K.C., Napoli, J.L., Gudas, L., Dräger, U.C. Dev. Biol. (1993) [Pubmed]
  6. Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse. Dollé, P., Ruberte, E., Kastner, P., Petkovich, M., Stoner, C.M., Gudas, L.J., Chambon, P. Nature (1989) [Pubmed]
  7. Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220. Park, S.W., Li, G., Lin, Y.P., Barrero, M.J., Ge, K., Roeder, R.G., Wei, L.N. Mol. Cell (2005) [Pubmed]
  8. Demethylation in the 5'-flanking region of mouse cellular retinoic acid binding protein-I gene is associated with its high level of expression in mouse embryos and facilitates its induction by retinoic acid in P19 embryonal carcinoma cells. Wei, L.N., Lee, C.H. Dev. Dyn. (1994) [Pubmed]
  9. Effect of malignant transformation upon the cellular retinoid binding proteins in cultured murine mammary cells. Bunk, M.J., Telang, N.T., Sarkar, N.H. Cancer Lett. (1983) [Pubmed]
  10. Retinoid binding protein activities in murine embryonal carcinoma cells and their differentiated derivatives. Matthaei, K.I., McCue, P.A., Sherman, M.I. Cancer Res. (1983) [Pubmed]
  11. The effect of dibutyryl cyclic AMP and butyrate on F9 teratocarcinoma cellular retinoic acid-binding protein activity. Grippo, J.F., Gudas, L.J. J. Biol. Chem. (1987) [Pubmed]
  12. Terminal bifunctional retinoids. Synthesis and evaluations related to cancer chemopreventive activity. Shealy, Y.F., Krauth, C.A., Riordan, J.M., Sani, B.P. J. Med. Chem. (1988) [Pubmed]
  13. Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis. Ruberte, E., Friederich, V., Morriss-Kay, G., Chambon, P. Development (1992) [Pubmed]
  14. Spatio-temporal distribution of cellular retinoid binding protein gene transcripts in the developing and the adult cochlea. Morphological and functional consequences in CRABP- and CRBPI-null mutant mice. Romand, R., Sapin, V., Ghyselinck, N.B., Avan, P., Le Calvez, S., Dollé, P., Chambon, P., Mark, M. Eur. J. Neurosci. (2000) [Pubmed]
  15. Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Sapin, V., Ward, S.J., Bronner, S., Chambon, P., Dollé, P. Dev. Dyn. (1997) [Pubmed]
  16. Role of retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid. Zetterström, R.H., Lindqvist, E., Mata de Urquiza, A., Tomac, A., Eriksson, U., Perlmann, T., Olson, L. Eur. J. Neurosci. (1999) [Pubmed]
  17. Activation of retinoic acid signalling after sciatic nerve injury: up-regulation of cellular retinoid binding proteins. Zhelyaznik, N., Schrage, K., McCaffery, P., Mey, J. Eur. J. Neurosci. (2003) [Pubmed]
  18. Retinoid-binding proteins in the cerebellum and choroid plexus and their relationship to regionalized retinoic acid synthesis and degradation. Yamamoto, M., Dräger, U.C., Ong, D.E., McCaffery, P. Eur. J. Biochem. (1998) [Pubmed]
  19. Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development. Ruberte, E., Friederich, V., Chambon, P., Morriss-Kay, G. Development (1993) [Pubmed]
  20. Replacement of proline with valine does not remove an apparent proline isomerization-dependent folding event in CRABP I. Burns-Hamuro, L.L., Dalessio, P.M., Ropson, I.J. Protein Sci. (2004) [Pubmed]
  21. Antisense oligonucleotides to CRABP I and II alter the expression of TGF-beta 3, RAR-beta, and tenascin in primary cultures of embryonic palate cells. Nugent, P., Greene, R.M. In Vitro Cell. Dev. Biol. Anim. (1995) [Pubmed]
  22. TGF-beta modulates the expression of retinoic acid-induced RAR-beta in primary cultures of embryonic palate cells. Nugent, P., Potchinsky, M., Lafferty, C., Greene, R.M. Exp. Cell Res. (1995) [Pubmed]
  23. Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo. Gustafson, A.L., Dencker, L., Eriksson, U. Development (1993) [Pubmed]
  24. FGF-2, BMP-2, and BMP-4 regulate retinoid binding proteins and receptors in 3T3 cells. Means, A.L., Gudas, L.J. Cell Growth Differ. (1996) [Pubmed]
  25. Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells. Boylan, J.F., Gudas, L.J. J. Cell Biol. (1991) [Pubmed]
  26. Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Ruberte, E., Dolle, P., Chambon, P., Morriss-Kay, G. Development (1991) [Pubmed]
  27. Temporal/spatial expression of retinoid binding proteins and RAR isoforms in the postnatal lung. Hind, M., Corcoran, J., Maden, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  28. Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene. Wei, L.N., Hu, X. Mol. Cell. Endocrinol. (2004) [Pubmed]
  29. Spatial and temporal pattern of expression of the cellular retinoic acid-binding protein and the cellular retinol-binding protein during mouse embryogenesis. Perez-Castro, A.V., Toth-Rogler, L.E., Wei, L.N., Nguyen-Huu, M.C. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  30. Cellular retinoic acid binding protein is associated with mitochondria. Ruff, S.J., Ong, D.E. FEBS Lett. (2000) [Pubmed]
  31. Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Giguère, V., Lyn, S., Yip, P., Siu, C.H., Amin, S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  32. The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture. Kelley, M.W., Xu, X.M., Wagner, M.A., Warchol, M.E., Corwin, J.T. Development (1993) [Pubmed]
WikiGenes - Universities