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Gene Review

Scd2  -  stearoyl-Coenzyme A desaturase 2

Mus musculus

Synonyms: Acyl-CoA desaturase 2, Delta(9)-desaturase 2, Delta-9 desaturase 2, Fatty acid desaturase 2, Scd-2, ...
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Disease relevance of Scd2


High impact information on Scd2

  • The liver, skin, and plasma triglyceride contents are decreased in the neonates but are not altered in the adult Scd2-/- mice [2].
  • SCD2-deficient (Scd2-/-) neonatal mice have a skin permeability barrier defect and a specific repartitioning of linoleic acid from epidermal acylceramide species into phospholipids [2].
  • Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development [2].
  • Taken together these results suggest that the PRE site and binding protein may regulate transcription of SCD2 and possibly other adipocyte genes by inhibiting their transcription in preadipocytes [3].
  • Transfection experiments with chimeric SCD2 promoter-chloramphenicol acetyltransferase (CAT) reporter gene constructs revealed a preadipocyte repressor element (PRE) capable of repressing transcription of the reporter gene in preadipocytes but not in adipocytes [3].

Biological context of Scd2


Anatomical context of Scd2

  • We previously identified stearoyl-CoA desaturase 2 (SCD2) as a new member of the family of genes that are transcriptionally regulated in response to changing levels of nuclear sterol regulatory element binding proteins (SREBPs) or adipocyte determination and differentiation factor 1 (ADD1) [5].
  • DNase I protection and gel retardation analyses were used to localize the PRE site between nucleotides -435 and -410 of the SCD2 promoter and to identify a nuclear PRE binding protein present at high levels in preadipocytes and HeLa cells but lacking or inactive in adipocytes [3].
  • The finding that the endogenous SCD2 mRNA levels were induced when wild-type Chinese hamster ovary fibroblasts were incubated in sterol-deficient medium is consistent with a role for SREBP in regulating transcription of the gene [6].

Associations of Scd2 with chemical compounds

  • A novel sterol regulatory element (SRE) (5'-AGCAGATTGTG-3') identified in the proximal promoter of the mouse SCD2 gene is required for induction of SCD2 promoter-reporter genes in response to cellular sterol depletion (Tabor, D. E., Kim, J. B., Spiegelman, B. M., and Edwards, P. A. (1998) J. Biol. Chem. 273, 22052-22058) [5].
  • By using the protein synthesis inhibitor, cycloheximide, we also show that the 20:4-mediated regulatory effects upon SCD2 or c-fos are completely independent of new protein synthesis [7].
  • Moreover, oxidized metabolites of 20:4 (15-HPETE and 15-HETE) failed to diminish SCD2 mRNA accumulation whereas 20:4 itself was effective in completely suppressing SCD2 gene expression [7].
  • During the time period when stearoyl-CoA desaturase 2 transcription and unsaturated fatty acid synthesis increased (6-12 h), there was only a minimal depletion (approximately 2%) of the total phospholipid arachidonic acid-content [8].
  • Induction of stearoyl-CoA desaturase 2 gene expression correlates with fatty acid changes in phosphatidylcholine [8].

Other interactions of Scd2


  1. Gene expression changes associated with chemically induced rat mammary carcinogenesis. Lu, J., Pei, H., Kaeck, M., Thompson, H.J. Mol. Carcinog. (1997) [Pubmed]
  2. Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Miyazaki, M., Dobrzyn, A., Elias, P.M., Ntambi, J.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Identification of a transcriptional repressor down-regulated during preadipocyte differentiation. Swick, A.G., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. A cluster of stearoyl CoA desaturase genes, Scd1 and Scd2, on mouse chromosome 19. Tabor, D.E., Xia, Y.R., Mehrabian, M., Edwards, P.A., Lusis, A.J. Mamm. Genome (1998) [Pubmed]
  5. Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2. Tabor, D.E., Kim, J.B., Spiegelman, B.M., Edwards, P.A. J. Biol. Chem. (1999) [Pubmed]
  6. Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1. Tabor, D.E., Kim, J.B., Spiegelman, B.M., Edwards, P.A. J. Biol. Chem. (1998) [Pubmed]
  7. Independent arachidonic acid-mediated gene regulatory pathways in lymphocytes. Tebbey, P.W., Buttke, T.M. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  8. Induction of stearoyl-CoA desaturase 2 gene expression correlates with fatty acid changes in phosphatidylcholine. Tebbey, P.W., Van Cleave, S., Buttke, T.M. Biochem. Mol. Biol. Int. (1994) [Pubmed]
  9. Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Zheng, Y., Prouty, S.M., Harmon, A., Sundberg, J.P., Stenn, K.S., Parimoo, S. Genomics (2001) [Pubmed]
  10. Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells. Christianson, J.L., Nicoloro, S., Straubhaar, J., Czech, M.P. J. Biol. Chem. (2008) [Pubmed]
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