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Gene Review

Slc17a1  -  solute carrier family 17 (sodium...

Mus musculus

Synonyms: NAPI-1, Na(+)/PI cotransporter 1, Napi1, Npt1, Renal Na(+)-dependent phosphate cotransporter 1, ...
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Disease relevance of Slc17a1


High impact information on Slc17a1


Biological context of Slc17a1

  • Assignment of renal specific Na(+)-phosphate cotransporter gene Slc17a1 to mouse chromosome bands 13A3-->A4 by in situ hybridization [9].
  • Transient transfection experiments confirmed that HNF1alpha directly transactivates the Npt1 promoter and that the HSS3 region contributes to this activation [10].
  • The Npt1 promoter has a TATA-like box but no CAAT box, and the transcription start site was identified by primer extension and 5'-rapid amplification of cDNA ends [11].
  • We suggest that Npt1 expression is transcriptionally regulated and provide a basis for the investigation of Npt1 function by targeted mutagenesis [11].

Anatomical context of Slc17a1

  • Degradation of Npt-1 or Glvr-1 mRNAs induced by corresponding antisense oligonucleotides had no effect on Pi transport, which was subsequently measured in oocytes [12].

Associations of Slc17a1 with chemical compounds


Regulatory relationships of Slc17a1


Other interactions of Slc17a1


Analytical, diagnostic and therapeutic context of Slc17a1


  1. Modulation of phosphate uptake and amphotropic murine leukemia virus entry by posttranslational modifications of PIT-2. Rodrigues, P., Heard, J.M. J. Virol. (1999) [Pubmed]
  2. FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. Shimada, T., Urakawa, I., Yamazaki, Y., Hasegawa, H., Hino, R., Yoneya, T., Takeuchi, Y., Fujita, T., Fukumoto, S., Yamashita, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  3. Nephrolithiasis, osteoporosis, and mutations in the type 2a sodium-phosphate cotransporter. Scheinman, S.J., Tenenhouse, H.S. N. Engl. J. Med. (2003) [Pubmed]
  4. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Shenolikar, S., Voltz, J.W., Minkoff, C.M., Wade, J.B., Weinman, E.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Hilfiker, H., Hattenhauer, O., Traebert, M., Forster, I., Murer, H., Biber, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa). Bachmann, S., Schlichting, U., Geist, B., Mutig, K., Petsch, T., Bacic, D., Wagner, C.A., Kaissling, B., Biber, J., Murer, H., Willnow, T.E. J. Am. Soc. Nephrol. (2004) [Pubmed]
  7. The effects of bone marrow transplantation on X-linked hypophosphatemic mice. Miyamura, T., Tanaka, H., Inoue, M., Ichinose, Y., Seino, Y. J. Bone Miner. Res. (2000) [Pubmed]
  8. Na+ -phosphate cotransport in mouse distal convoluted tubule cells: evidence for Glvr-1 and Ram-1 gene expression. Tenenhouse, H.S., Gauthier, C., Martel, J., Gesek, F.A., Coutermarsh, B.A., Friedman, P.A. J. Bone Miner. Res. (1998) [Pubmed]
  9. Assignment of renal specific Na(+)-phosphate cotransporter gene Slc17a1 to mouse chromosome bands 13A3-->A4 by in situ hybridization. Zhang, X.X., Tenenhouse, H.S., Hewson, A.S., Eydoux, P. Cytogenet. Cell Genet. (1997) [Pubmed]
  10. Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus. Cheret, C., Doyen, A., Yaniv, M., Pontoglio, M. J. Mol. Biol. (2002) [Pubmed]
  11. Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity. Soumounou, Y., Gauthier, C., Tenenhouse, H.S. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  12. Relative contributions of Na+-dependent phosphate co-transporters to phosphate transport in mouse kidney: RNase H-mediated hybrid depletion analysis. Miyamoto, K., Segawa, H., Morita, K., Nii, T., Tatsumi, S., Taketani, Y., Takeda, E. Biochem. J. (1997) [Pubmed]
  13. Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Npt1. Uchino, H., Tamai, I., Yabuuchi, H., China, K., Miyamoto, K., Takeda, E., Tsuji, A. Antimicrob. Agents Chemother. (2000) [Pubmed]
  14. Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter. Chong, S.S., Kozak, C.A., Liu, L., Kristjansson, K., Dunn, S.T., Bourdeau, J.E., Hughes, M.R. Am. J. Physiol. (1995) [Pubmed]
  15. Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. Chong, S.S., Kristjansson, K., Zoghbi, H.Y., Hughes, M.R. Genomics (1993) [Pubmed]
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