The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Slc20a1  -  solute carrier family 20, member 1

Mus musculus

Synonyms: AI607883, GLVR-1, Gibbon ape leukemia virus receptor 1, Glvr-1, Glvr1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Slc20a1


High impact information on Slc20a1


Chemical compound and disease context of Slc20a1

  • Strikingly, the amino acid sequence of the fourth extracellular loop, which is critical for GALV surface glycoprotein binding, has complete identity between the human and feline PiT-1s, while the mouse PiT-1, non-functional for GALV entry, is quite divergent [5].

Biological context of Slc20a1

  • Glvr-1 was then mapped in the mouse by interspecies backcrosses and found to map to chromosome 2 in a region of linkage conservation with human chromosome 2 [1].
  • To investigate whether Glvr-1 and Rec-2 could be the same gene, we sought evidence for sequence homology between the env- genes of their respective viruses [2].
  • This pattern of Glvr-1 mRNA expression was maintained throughout embryonic development until after birth [3].
  • In conclusion, the Glvr-1 phosphate transporter is selectively expressed in a subset of hypertrophic chondrocytes during endochondral bone formation, in a region where matrix mineralization proceeds [3].
  • Na+ -phosphate cotransport in mouse distal convoluted tubule cells: evidence for Glvr-1 and Ram-1 gene expression [10].

Anatomical context of Slc20a1


Physical interactions of Slc20a1

  • In this study, we investigated the effect of TGF-beta1 on inorganic phosphate (Pi) transport and on expression of the type III Pi carriers Glvr-1 and Ram-1 in murine ATDC5 chondrocytes [12].

Regulatory relationships of Slc20a1

  • In conclusion, TGF-beta1 stimulates Pi transport and Glvr-1 expression in chondrocytes, suggesting that, like proliferation, differentiation, and matrix synthesis, Pi handling is subject to regulation by TGF-beta3 family members in bone-forming cells [12].

Other interactions of Slc20a1

  • Npt2 mRNA was localized to proximal tubules in the renal outer cortex, whereas Glvr-1 transcripts were detected throughout the kidney by in situ hybridization [13].
  • Glvr-1 thus likely mediates at least part of the increase in Pi uptake induced by TGF-beta1 [12].
  • Degradation of Npt-1 or Glvr-1 mRNAs induced by corresponding antisense oligonucleotides had no effect on Pi transport, which was subsequently measured in oocytes [14].

Analytical, diagnostic and therapeutic context of Slc20a1

  • Consistently, Northern blotting analysis showed a dose-dependent increase in Glvr-1 messenger RNA expression in response to TGF-beta1, which preceded the maximal stimulation of Pi transport by several hours [12].


  1. Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2. Kaelbling, M., Eddy, R., Shows, T.B., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Klinger, H.P., O'Hara, B. J. Virol. (1991) [Pubmed]
  2. The mouse homolog of the Gibbon ape leukemia virus receptor: genetic mapping and a possible receptor function in rodents. Adamson, M.C., Silver, J., Kozak, C.A. Virology (1991) [Pubmed]
  3. In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retrovirus receptor during bone development. Palmer, G., Zhao, J., Bonjour, J., Hofstetter, W., Caverzasio, J. Bone (1999) [Pubmed]
  4. Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation. Wang, W., Jobbagy, Z., Bird, T.H., Eiden, M.V., Anderson, W.B. J. Biol. Chem. (2005) [Pubmed]
  5. Retrovirus receptor PiT-1 of the Felis catus. Rudra-Ganguly, N., Ghosh, A.K., Roy-Burman, P. Biochim. Biophys. Acta (1998) [Pubmed]
  6. Developmental-stage-specific expression and regulation of an amphotropic retroviral receptor in hematopoietic cells. Richardson, C., Bank, A. Mol. Cell. Biol. (1996) [Pubmed]
  7. Fungal phosphate transporter serves as a receptor backbone for gibbon ape leukemia virus. Pedersen, L., van Zeijl, M., Johann, S.V., O'Hara, B. J. Virol. (1997) [Pubmed]
  8. Mutation of amino acids within the gibbon ape leukemia virus (GALV) receptor differentially affects feline leukemia virus subgroup B, simian sarcoma-associated virus, and GALV infections. Tailor, C.S., Takeuchi, Y., O'Hara, B., Johann, S.V., Weiss, R.A., Collins, M.K. J. Virol. (1993) [Pubmed]
  9. GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus. Johann, S.V., Gibbons, J.J., O'Hara, B. J. Virol. (1992) [Pubmed]
  10. Na+ -phosphate cotransport in mouse distal convoluted tubule cells: evidence for Glvr-1 and Ram-1 gene expression. Tenenhouse, H.S., Gauthier, C., Martel, J., Gesek, F.A., Coutermarsh, B.A., Friedman, P.A. J. Bone Miner. Res. (1998) [Pubmed]
  11. Amphotropic murine leukemia virus is preferentially attached to cholesterol-rich microdomains after binding to mouse fibroblasts. Beer, C., Pedersen, L. Virol. J. (2006) [Pubmed]
  12. Transforming growth factor-beta stimulates inorganic phosphate transport and expression of the type III phosphate transporter Glvr-1 in chondrogenic ATDC5 cells. Palmer, G., Guicheux, J., Bonjour, J.P., Caverzasio, J. Endocrinology (2000) [Pubmed]
  13. Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney. Tenenhouse, H.S., Roy, S., Martel, J., Gauthier, C. Am. J. Physiol. (1998) [Pubmed]
  14. Relative contributions of Na+-dependent phosphate co-transporters to phosphate transport in mouse kidney: RNase H-mediated hybrid depletion analysis. Miyamoto, K., Segawa, H., Morita, K., Nii, T., Tatsumi, S., Taketani, Y., Takeda, E. Biochem. J. (1997) [Pubmed]
WikiGenes - Universities