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Gene Review

Sox15  -  SRY (sex determining region Y)-box 15

Mus musculus

Synonyms: Protein SOX-15, Sox-15
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Disease relevance of Sox15


High impact information on Sox15


Biological context of Sox15


Anatomical context of Sox15


Regulatory relationships of Sox15


Other interactions of Sox15

  • In contrast to the early embryonic lethality observed in Sox2-null mice, Sox15-null ES cells and mice were grossly normal [3].
  • These results may suggest that the increased transcriptional activity of Hand1 caused by Sox15 might promote the transcription of the target gene resulting in the trophoblast giant cell differentiation in the mouse placenta [1].
  • Here, we report the isolation and characterization of mouse Sox15 that was uncovered during a screen for high mobility group box containing transcription factors that are expressed at different levels during skeletal muscle differentiation [5].
  • Here, we report that Sox15 transcripts were much more abundant in mouse placenta than in the fetus, the yolk sac, or several adult tissues [1].


  1. Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta. Yamada, K., Kanda, H., Tanaka, S., Takamatsu, N., Shiba, T., Ito, M. Differentiation (2006) [Pubmed]
  2. Sox15 is required for skeletal muscle regeneration. Lee, H.J., Göring, W., Ochs, M., Mühlfeld, C., Steding, G., Paprotta, I., Engel, W., Adham, I.M. Mol. Cell. Biol. (2004) [Pubmed]
  3. Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. Maruyama, M., Ichisaka, T., Nakagawa, M., Yamanaka, S. J. Biol. Chem. (2005) [Pubmed]
  4. Sox15 is up regulated in the embryonic mouse testis. Sarraj, M.A., Wilmore, H.P., McClive, P.J., Sinclair, A.H. Gene Expr. Patterns (2003) [Pubmed]
  5. Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family. Béranger, F., Méjean, C., Moniot, B., Berta, P., Vandromme, M. J. Biol. Chem. (2000) [Pubmed]
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