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Gene Review

Aurkb  -  aurora kinase B

Mus musculus

Synonyms: AIM-1, AIRK2, AL022959, ARK-2, Aik2, ...
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Disease relevance of Aurkb


High impact information on Aurkb


Biological context of Aurkb

  • Nevertheless, STK-1 is conserved throughout phylogeny with hybridizing sequences being detected in DNA from mammals, amphibians, insects and yeast [5].
  • We have cloned a novel putative serine/threonine kinase-encoding gene, designed STK-1, from murine embryonic stem (ES) cell and testis cDNA libraries [5].
  • We found that the mitotic cell death symptoms correlated with attenuated expression of survivin, a member of the chromosomal passenger complex, and mislocalization of Aurora B, the partner of survivin in the chromosomal passenger complex [6].

Anatomical context of Aurkb

  • Cell lines and primary tumors derived from the TRAMP model were also found to express high levels of Aurora-A and Aurora-B [1].
  • In NIH 3T3 cells, STK-1 is expressed in a cell-cycle-dependent fashion [5].


  1. Targeting Aurora kinases for the treatment of prostate cancer. Lee, E.C., Frolov, A., Li, R., Ayala, G., Greenberg, N.M. Cancer Res. (2006) [Pubmed]
  2. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. Lens, S.M., Wolthuis, R.M., Klompmaker, R., Kauw, J., Agami, R., Brummelkamp, T., Kops, G., Medema, R.H. EMBO J. (2003) [Pubmed]
  3. E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress. Polager, S., Ginsberg, D. J. Biol. Chem. (2003) [Pubmed]
  4. The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Krupczak-Hollis, K., Wang, X., Kalinichenko, V.V., Gusarova, G.A., Wang, I.C., Dennewitz, M.B., Yoder, H.M., Kiyokawa, H., Kaestner, K.H., Costa, R.H. Dev. Biol. (2004) [Pubmed]
  5. Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase. Niwa, H., Abe, K., Kunisada, T., Yamamura, K. Gene (1996) [Pubmed]
  6. Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-expressing cells. Wolanin, K., Magalska, A., Mosieniak, G., Klinger, R., McKenna, S., Vejda, S., Sikora, E., Piwocka, K. Mol. Cancer Res. (2006) [Pubmed]
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