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Gene Review

Stmn1  -  stathmin 1

Mus musculus

Synonyms: 19K, 19k, AI131641, Lag, Lap18, ...
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Disease relevance of Stmn1

  • To explore the structural and evolutionary relationships between these genes, we have isolated a series of cosmid and phage clones that covers the entire region of the mouse stathmin gene and most of the mouse SCG10 gene [1].
  • Murine erythroleukemia cells showed a moderate increase followed by a marked decrease in the abundance of p19 mRNA during induction of differentiation [2].
  • MHC-specific peptides were also isolated from cells expressing mouse Kd class I MHC molecules whose cytoplasmic domain was substituted by that of the adenovirus E3/19K glycoprotein [3].
  • Lung adenomas exhibited a 50% decrease and a 35-fold increase in expression of Rb and p19/ARF mRNA, respectively [4].
  • In contrast, we describe in this study that newly created LacZ knockin mice deficient for IL-23 p19 were highly susceptible for the development of experimental T cell-mediated TNBS colitis and showed even more severe colitis than wild-type mice by endoscopic and histologic criteria [5].
  • These data suggest that KIS protects against excessive neointima formation by opposing stathmin-mediated VSMC migration and that VSMC migration represents a major mechanism of vascular wound repair, constituting a relevant target and mechanism for therapeutic interventions [6].

High impact information on Stmn1

  • We have identified stathmin, an inhibitor of microtubule formation, as highly expressed in the lateral nucleus (LA) of the amygdala as well as in the thalamic and cortical structures that send information to the LA about the conditioned (learned fear) and unconditioned stimuli (innate fear) [7].
  • stathmin, a gene enriched in the amygdala, controls both learned and innate fear [7].
  • By contrast, these mice do not show deficits in the water maze, a spatial task dependent on the hippocampus, where stathmin is not normally expressed [7].
  • Whole-cell recordings from amygdala slices that are isolated from stathmin knockout mice show deficits in spike-timing-dependent long-term potentiation (LTP) [7].
  • Overexpression of tsg101 antisense transcripts in naive 3T3 cells resulted in cell transformation and increased stathmin-specific mRNA [8].

Chemical compound and disease context of Stmn1


Biological context of Stmn1


Anatomical context of Stmn1


Associations of Stmn1 with chemical compounds

  • We show here that sustained G(2)/M arrest induced by the genotoxic agent doxorubicin is E2F-dependent and involves a decrease in expression of two mitotic regulators, Stathmin and AIM-1 [14].
  • However, they revealed a subpopulation of cells in which stathmin was highly phosphorylated on serine 16, possibly by CaM kinase II also active in a similar subpopulation [15].
  • In murine C2 myoblasts and primary fetal rat osteoblasts, p19 mRNA was abundant in replicating cells and decreased to undetectable levels during differentiation [2].
  • Consistent with a role as chaperones, we find that glucose starvation induces complex formation between p100/110 and MHC-E3/19K [16].
  • In the present study we have assessed the complexity of the transcriptome expressed in mouse macrophages before and after treatment with lipopolysaccharide, a global regulator of macrophage gene expression, using existing RIKEN 19K arrays [17].

Physical interactions of Stmn1


Enzymatic interactions of Stmn1


Regulatory relationships of Stmn1


Other interactions of Stmn1


Analytical, diagnostic and therapeutic context of Stmn1

  • To explore its potential role in mammalian development, we have disrupted the gene encoding metablastin by gene targeting in mice [10].
  • Identification of the pro-oncogene stathmin/op18 mRNA in the brain of mitochondrial Mn-superoxide dismutase-deficient mice by a modified differential display PCR [20].
  • RT-PCR analysis revealed a low expression of stathmin mRNA in unfertilized oocytes and a higher expression at the blastocyst stage [21].
  • By Western blot analysis, Pr22 was detected in the nuclear fraction but not in the cytoplasm [22].
  • Primary cultures of embryonic and neonatal rat brain were analyzed by indirect immunofluorescence using co-staining with stage-specific markers. p19 expression was restricted to immature neurons and oligodendrocyte precursors [2].


  1. Molecular diversity of the SCG10/stathmin gene family in the mouse. Okazaki, T., Yoshida, B.N., Avraham, K.B., Wang, H., Wuenschell, C.W., Jenkins, N.A., Copeland, N.G., Anderson, D.J., Mori, N. Genomics (1993) [Pubmed]
  2. Widespread differentiation stage-specific expression of the gene encoding phosphoprotein p19 (metablastin) in mammalian cells. Schubart, U.K., Xu, J., Fan, W., Cheng, G., Goldstein, H., Alpini, G., Shafritz, D.A., Amat, J.A., Farooq, M., Norton, W.T. Differentiation (1992) [Pubmed]
  3. Class I molecules retained in the endoplasmic reticulum bind antigenic peptides. Lapham, C.K., Bacík, I., Yewdell, J.W., Kane, K.P., Bennink, J.R. J. Exp. Med. (1993) [Pubmed]
  4. In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Yu, Z., Loehr, C.V., Fischer, K.A., Louderback, M.A., Krueger, S.K., Dashwood, R.H., Kerkvliet, N.I., Pereira, C.B., Jennings-Gee, J.E., Dance, S.T., Miller, M.S., Bailey, G.S., Williams, D.E. Cancer Res. (2006) [Pubmed]
  5. Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. Becker, C., Dornhoff, H., Neufert, C., Fantini, M.C., Wirtz, S., Huebner, S., Nikolaev, A., Lehr, H.A., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Galle, P.R., Karow, M., Neurath, M.F. J. Immunol. (2006) [Pubmed]
  6. KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice. Langenickel, T.H., Olive, M., Boehm, M., San, H., Crook, M.F., Nabel, E.G. J. Clin. Invest. (2008) [Pubmed]
  7. stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Shumyatsky, G.P., Malleret, G., Shin, R.M., Takizawa, S., Tully, K., Tsvetkov, E., Zakharenko, S.S., Joseph, J., Vronskaya, S., Yin, D., Schubart, U.K., Kandel, E.R., Bolshakov, V.Y. Cell (2005) [Pubmed]
  8. Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Li, L., Cohen, S.N. Cell (1996) [Pubmed]
  9. Immunomodulation by roquinimex decreases the expression of IL-23 (p19) mRNA in the brains of herpes simplex virus type 1 infected BALB/c mice. Peltoniemi, J., Broberg, E.K., Halenius, A., Setala, N., Eralinna, J.P., Salmi, A.A., Roytta, M., Hukkanen, V. Clin. Exp. Immunol. (2004) [Pubmed]
  10. Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation. Schubart, U.K., Yu, J., Amat, J.A., Wang, Z., Hoffmann, M.K., Edelmann, W. J. Biol. Chem. (1996) [Pubmed]
  11. Vascular endothelial zinc finger 1 is involved in the regulation of angiogenesis: possible contribution of stathmin/OP18 as a downstream target gene. Miyashita, H., Kanemura, M., Yamazaki, T., Abe, M., Sato, Y. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  12. Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Strey, C.W., Spellman, D., Stieber, A., Gonatas, J.O., Wang, X., Lambris, J.D., Gonatas, N.K. Am. J. Pathol. (2004) [Pubmed]
  13. Expression of stathmin family genes in the murine uterus during early pregnancy. Yoshie, M., Tamura, K., Hara, T., Kogo, H. Mol. Reprod. Dev. (2006) [Pubmed]
  14. E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress. Polager, S., Ginsberg, D. J. Biol. Chem. (2003) [Pubmed]
  15. Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons. Gavet, O., El Messari, S., Ozon, S., Sobel, A. J. Neurosci. Res. (2002) [Pubmed]
  16. Novel proteins associated with MHC class I antigens in cells expressing the adenovirus protein E3/19K. Feuerbach, D., Burgert, H.G. EMBO J. (1993) [Pubmed]
  17. Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage. Wells, C.A., Ravasi, T., Sultana, R., Yagi, K., Carninci, P., Bono, H., Faulkner, G., Okazaki, Y., Quackenbush, J., Hume, D.A., Lyons, P.A. Genome Res. (2003) [Pubmed]
  18. Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death. Vancompernolle, K., Boonefaes, T., Mann, M., Fiers, W., Grooten, J. J. Biol. Chem. (2000) [Pubmed]
  19. Brain-derived neurotrophic factor stimulates phosphorylation of stathmin in cortical neurons. Cardinaux, J.R., Magistretti, P.J., Martin, J.L. Brain Res. Mol. Brain Res. (1997) [Pubmed]
  20. Identification of the pro-oncogene stathmin/op18 mRNA in the brain of mitochondrial Mn-superoxide dismutase-deficient mice by a modified differential display PCR. Li, Y., Chan, P.H. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  21. Cellular and subcellular localization of stathmin during oocyte and preimplantation embryo development. Koppel, J., Rehák, P., Baran, V., Veselá, J., Hlinka, D., Manceau, V., Sobel, A. Mol. Reprod. Dev. (1999) [Pubmed]
  22. Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control. Hosoya, H., Ishikawa, K., Dohi, N., Marunouchi, T. Cell Struct. Funct. (1996) [Pubmed]
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