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Gene Review

Wipf1  -  WAS/WASL interacting protein family, member 1

Mus musculus

Synonyms: AI115543, D2Ertd120e, WAS/WASL-interacting protein family member 1, WASP-interacting protein, WIP, ...
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Disease relevance of Wipf1

  • Our results indicate that WIP and N-WASP may act as a functional unit in filopodium formation, which is consistent with their role in actin-tail formation in cells infected with vaccinia virus or Shigella [1].
  • We have shown that WIP interacts with members of the Wiskott-Aldrich syndrome protein family and is essential for filopodium formation regulated by Cdc42 GTPase [2].

High impact information on Wipf1


Biological context of Wipf1

  • Calcium mobilization, phosphorylation of Syk, phospholipase C-g2, and c-Jun NH2-terminal kinase were markedly decreased in WIP-deficient BMMCs [3].

Anatomical context of Wipf1


Physical interactions of Wipf1

  • Here we show that WASP-interacting protein (WIP) interacts directly with N-WASP and actin [1].

Regulatory relationships of Wipf1

  • WIP regulates N-WASP-mediated actin polymerization and filopodium formation [1].


  1. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Martinez-Quiles, N., Rohatgi, R., Antón, I.M., Medina, M., Saville, S.P., Miki, H., Yamaguchi, H., Takenawa, T., Hartwig, J.H., Geha, R.S., Ramesh, N. Nat. Cell Biol. (2001) [Pubmed]
  2. WIP participates in actin reorganization and ruffle formation induced by PDGF. Antón, I.M., Saville, S.P., Byrne, M.J., Curcio, C., Ramesh, N., Hartwig, J.H., Geha, R.S. J. Cell. Sci. (2003) [Pubmed]
  3. WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. Kettner, A., Kumar, L., Antón, I.M., Sasahara, Y., de la Fuente, M., Pivniouk, V.I., Falet, H., Hartwig, J.H., Geha, R.S. J. Exp. Med. (2004) [Pubmed]
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