Disease relevance of Tooth Eruption

• Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis [1].
• In contrast, there was no indication of increased bone resorption, no appearance of osteoclasts, and no tooth eruption in response to GM-CSF treatment [2].
• Acceleration of tooth eruption and eyelid opening as well as attenuation of weight gain was most marked in C3H/He mice and the induction of serum amyloid protein was the largest in ddY mice [3].
• Alopecia, Pseudo- anodontia (failure of tooth eruption), and progressive Optic atrophy [4].
• Indications for tibial bone grafting included facilitation of tooth eruption into the graft, giving bony support to the neighbouring teeth, making it possible to insert a titanium fixture, raising the alar base of the nose, and closing an oronasal fistula [5].

High impact information on Tooth Eruption

• The initial observations of Stanley Cohen in the 1960s established that EGF induced in vivo effects such as precocious eyelid opening and tooth eruption [6].
• Here we report that mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function [7].
• Parathyroid hormone-related protein is required for tooth eruption [8].
• The reproductive, hematopoietic tooth eruption and tissue macrophage defects of CSF-1-deficient, osteopetrotic Csf1(op)/Csf1(op) mice were corrected by transgenic expression of the precursors of either sgCSF-1 or spCSF-1 [9].
• Animals homozygous for the null Acp 5 allele had progressive foreshortening and deformity of the long bones and axial skeleton but apparently normal tooth eruption and skull plate development, indicating a rôle for Acp 5 in endochondral ossification [10].

Chemical compound and disease context of Tooth Eruption

• Tartrate-resistant acid phosphatase in mononuclear and multinuclear cells during the bone resorption of tooth eruption [11].
• Bafilomycin A1 in bone resorption and tooth eruption in dogs [12].
• Because bone resorption is stimulated by dexamethasone both in vivo and in vitro, dexamethasone 21-phosphate, a soluble form of dexamethasone, was injected into rats to determine its effect on tooth eruption [13].

Biological context of Tooth Eruption

• Pamidronate does not inhibit the gene expression of the putative tooth eruption molecules, colony-stimulating factor-1 and c-fos, both of which are expressed in the dental follicle, the tissue that is required for eruption to occur [14].
• Continuous exposure results demonstrate that cadmium (1) significantly decreased bone calcium content (14-15%) and concentration (12-13%) in both fos+/o and fos-/- mice, (2) doubled multinucleated osteoclast-like cell number in fos-/- bones, and (3) stimulated tooth eruption in 40% of fos-/- mice [15].
• Molecules that accelerate tooth eruption, epidermal growth factor (EGF) and colony-stimulating factor-1 (CSF-1), enhance the expression of the c-fos gene in vitro in both a time- and concentration-dependent manner [16].
• Dense incisors (din): a new mouse mutation on chromosome 16 affecting tooth eruption and body size [17].
• Relationship between the tooth eruption and regional blood flow in angiotensin II-induced hypertensive rats [18].

Anatomical context of Tooth Eruption

• As summarized in this review EGF has been implicated in a number of developmental events including palate and skin differentiation, growth of hair follicles, eye opening and tooth eruption, lung maturation, gut and liver growth, and differentiation of neurons [6].
• Furthermore, it corrected at birth the growth plate abnormalities of PTHrP-/- mice and allowed their prolonged survival. "Rescued" animals lacked tooth eruption and showed premature epiphyseal closure, indicating that both processes involve PTHrP [19].
• These results suggest that TNF receptor signaling can affect tooth eruption by acting as a monocyte survival signal in some but not all areas of bone undergoing developmentally regulated remodeling [20].
• Changes in the tartrate-resistant acid phosphatase cell population in dental follicles and bony crypts of rat molars during tooth eruption [21].
• Expression of MMP-8 and MMP-13 mRNAs in rat periodontium during tooth eruption [22].

Associations of Tooth Eruption with chemical compounds

• Cyclic AMP in dental and periodontal tissues during tooth eruption in kittens [23].
• Daily use of fluoridated dentifrices from tooth eruption is more efficacious than daily use of fluoride supplements from birth [24].
• Cyclic adenosine 3',5'-monophosphate (cAMP) concentrations and cellular distribution were studied in dental and periodontal tissues during tooth eruption in kittens [23].
• Estimates based on tooth eruption of modern humans, as well as occlusal wear and root development, suggest an age at death of between 12.5 and 14.5 years [25].
• The best explanation of these findings and similar reports in the anthropological literature is that continuous tooth eruption occurred without the concomitant coronal movement of alveolar bone [26].

Gene context of Tooth Eruption

• Osteoprotegerin and osteoclast differentiation factor in tooth eruption [27].
• Evidence thus far supports a role for an osteoblast-specific transcription factor, Cbfa1 (Runx2), in molecular events that regulate tooth eruption [28].
• At the time of tooth eruption, Timp-3 was expressed in most dental epithelial cells except secretory ameloblasts, and gelatinase B was intensely expressed in osteoclasts in the jaw bone [29].
• Consistent with this, MCP-1(-/-) mice had an accelerated rate of tooth eruption in the early phase when the teeth first entered the oral cavity as compared with the wild-type mice [30].
• Activation of protein kinase C (PKC) can upregulate tooth eruption molecules such as osteoprotegerin (OPG) and vascular endothelial growth factor (VEGF) [31].

Analytical, diagnostic and therapeutic context of Tooth Eruption

• The fibre elongations appear to influence tooth eruption, the clinical behaviour of splinted and non-splinted teeth, and the establishment of vertical dimension of occlusion and occlusal plane height [32].
• Principles of cosmetic dentistry in orthodontics: Part 3. Laser treatments for tooth eruption and soft tissue problems [33].

References