The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Wisp1  -  WNT1 inducible signaling pathway protein 1

Mus musculus

Synonyms: AW146261, CCN family member 4, CCN4, Ccn4, ELM-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Wisp1

  • We previously isolated a partial cDNA fragment of a novel gene, Elm1 (expressed in low-metastatic cells), that is expressed in low-metastatic but not in high-metastatic K-1735 mouse melanoma cells [1].
  • 3. WISP-1 genomic DNA was amplified in colon cancer cell lines and in human colon tumors and its RNA overexpressed (2- to >30-fold) in 84% of the tumors examined compared with patient-matched normal mucosa [2].

High impact information on Wisp1


Biological context of Wisp1


Anatomical context of Wisp1

  • We evaluated the effect of WISP-1 on chondrocytes by generating stably transfected mouse chondrocytic cell lines [3].
  • By using a solid phase assay, we showed that human skin fibroblast conditioned media contained WISP-1 binding factors [4].

Associations of Wisp1 with chemical compounds

  • Similarly, WISP-1 interaction with human skin fibroblasts was inhibited by dermatan sulfate, decorin, and biglycan or by treatment of the cell surface with dermatan sulfate-specific lyases [4].

Other interactions of Wisp1

  • This result was subsequently confirmed by real-time quantitative RT-PCR (IGF-1; 0.74+/-0.08 and 0.56+/-0.08, WISP-1; 0.71+/-0.03 and 0.56+/-0.08, and VEGF-C; 0.67+/-0.01 and 0.80+/-0.07, mean+/-SEM, compared with the control at zero and two days after induction of differentiation, respectively) [6].


  1. Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells. Hashimoto, Y., Shindo-Okada, N., Tani, M., Nagamachi, Y., Takeuchi, K., Shiroishi, T., Toma, H., Yokota, J. J. Exp. Med. (1998) [Pubmed]
  2. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Pennica, D., Swanson, T.A., Welsh, J.W., Roy, M.A., Lawrence, D.A., Lee, J., Brush, J., Taneyhill, L.A., Deuel, B., Lew, M., Watanabe, C., Cohen, R.L., Melhem, M.F., Finley, G.G., Quirke, P., Goddard, A.D., Hillan, K.J., Gurney, A.L., Botstein, D., Levine, A.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. French, D.M., Kaul, R.J., D'Souza, A.L., Crowley, C.W., Bao, M., Frantz, G.D., Filvaroff, E.H., Desnoyers, L. Am. J. Pathol. (2004) [Pubmed]
  4. WISP-1 binds to decorin and biglycan. Desnoyers, L., Arnott, D., Pennica, D. J. Biol. Chem. (2001) [Pubmed]
  5. Microarray studies reveal macrophage-like function of stromal keratocytes in the cornea. Chakravarti, S., Wu, F., Vij, N., Roberts, L., Joyce, S. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  6. Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Kanazawa, A., Tsukada, S., Kamiyama, M., Yanagimoto, T., Nakajima, M., Maeda, S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
WikiGenes - Universities