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Gene Review

WISP1  -  WNT1 inducible signaling pathway protein 1

Homo sapiens

Synonyms: CCN family member 4, CCN4, WISP-1, WISP1c, WISP1i, ...
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Disease relevance of WISP1


High impact information on WISP1


Chemical compound and disease context of WISP1


Biological context of WISP1


Anatomical context of WISP1


Associations of WISP1 with chemical compounds

  • Indomethacin also down-regulated the expression of Bfl-1, WISP-1 and PCNA protein (40.01 +/- 1.61 vs 43.76 +/- 1.63, 22.50 +/- 1.17 vs 30.30 +/- 1.55, 17.69 +/- 1.18 vs 20.80 +/- 1.08) [6].

Other interactions of WISP1

  • CONCLUSIONS: Early induction of WNT5A, coupled with the coordinated induction and repression of genes that modulate the Wnt signaling pathway, led to the early, selective induction of WISP1 and no other Wnt-inducible genes [11].
  • Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines [10].
  • In an invasion assay across collagen I, an MMP-1 target matrix, WISP-1 cells were significantly less invasive compared with controls, whereas WISP-1/RacG12V cells showed elevated invasion levels [2].
  • We found a strong correlation between WISP-1 and COL11A1 expression in sporadic carcinomas [12].
  • Increased expression of cyclin D1, c-myc, and WISP-1 mRNAs in HMEG suggested activation of the Wnt-1/beta-catenin cascade [13].

Analytical, diagnostic and therapeutic context of WISP1

  • We performed microarray and real-time PCR analyses to identify genes involved in invasion that may be differentially regulated by WISP-1 [2].
  • Using differential display, RT-PCR and DNA sequencing analyses in normal human mammary epithelial cells (HMEC) and various breast tumor cell lines including MCF-7, ZR-75, T-47D and SKBR2, we demonstrated that WISP-1 and WISP-2 genes are differentially transcribed in these cells [10].
  • The expression of Bfl-1, WISP-1 and PCNA, mRNA and protein were determined by a real-time quantitative PCR and Western blot, respectively [6].


  1. Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Xie, D., Nakachi, K., Wang, H., Elashoff, R., Koeffler, H.P. Cancer Res. (2001) [Pubmed]
  2. Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. Soon, L.L., Yie, T.A., Shvarts, A., Levine, A.J., Su, F., Tchou-Wong, K.M. J. Biol. Chem. (2003) [Pubmed]
  3. WNT1 inducible signaling pathway protein 3, WISP-3, a novel target gene in colorectal carcinomas with microsatellite instability. Thorstensen, L., Diep, C.B., Meling, G.I., Aagesen, T.H., Ahrens, C.H., Rognum, T.O., Lothe, R.A. Gastroenterology (2001) [Pubmed]
  4. Wnt-1-inducible signaling pathway protein 3 and susceptibility to juvenile idiopathic arthritis. Lamb, R., Thomson, W., Ogilvie, E., Donn, R. Arthritis Rheum. (2005) [Pubmed]
  5. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Su, F., Overholtzer, M., Besser, D., Levine, A.J. Genes Dev. (2002) [Pubmed]
  6. Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells. Wang, J., Zhang, G.Y., Li, X.H. Chinese journal of digestive diseases. (2006) [Pubmed]
  7. Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells. Cervello, M., Giannitrapani, L., Labbozzetta, M., Notarbartolo, M., D'Alessandro, N., Lampiasi, N., Azzolina, A., Montalto, G. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  8. WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. Xu, L., Corcoran, R.B., Welsh, J.W., Pennica, D., Levine, A.J. Genes Dev. (2000) [Pubmed]
  9. Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. Yanagita, T., Kubota, S., Kawaki, H., Kawata, K., Kondo, S., Takano-Yamamoto, T., Tanaka, S., Takigawa, M. FEBS J. (2007) [Pubmed]
  10. Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines. Saxena, N., Banerjee, S., Sengupta, K., Zoubine, M.N., Banerjee, S.K. Mol. Cell. Biochem. (2001) [Pubmed]
  11. Gene expression after crush injury of human saphenous vein: using microarrays to define the transcriptional profile. Price, R.M., Tulsyan, N., Dermody, J.J., Schwalb, M., Soteropoulos, P., Castronuovo, J.J. J. Am. Coll. Surg. (2004) [Pubmed]
  12. COL11A1 in FAP polyps and in sporadic colorectal tumors. Fischer, H., Salahshor, S., Stenling, R., Björk, J., Lindmark, G., Iselius, L., Rubio, C., Lindblom, A. BMC Cancer (2001) [Pubmed]
  13. Targeted gene expression analysis in hemimegalencephaly: activation of beta-catenin signaling. Yu, J., Baybis, M., Lee, A., McKhann, G., Chugani, D., Kupsky, W.J., Aronica, E., Crino, P.B. Brain Pathol. (2005) [Pubmed]
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