The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Zscan21  -  zinc finger and SCAN domain containing 21

Mus musculus

Synonyms: AI326272, CTfin51, CtFIN51, RU49, Transcription factor RU49, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Zscan21

  • BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin [1].
  • We also show that Zipro1 is expressed in skin, and increased Zipro1 dosage results in a hair-loss phenotype associated with increased epithelial cell proliferation and abnormal hair follicle development [1].
  • We demonstrate a role for the zinc-finger transcription factor Zipro1 (formerly Ru49 and Zfp38) in the proliferation of granule cell precursors in the developing cerebellum, and document the contribution of this process to the final stages of cerebellar morphogenesis [1].
  • Isolation of rhombic lip cells reveals a homogenous population of precursor cells that express general neuronal markers and the granule cell marker RU49, but fail to extend neurites or express differentiation markers [2].
  • The IRES-LacZ marker gene was introduced into a 131 kb BAC containing the murine zinc finger gene, RU49 [3].

Biological context of Zscan21


Anatomical context of Zscan21


Regulatory relationships of Zscan21

  • Thus, RU49 is expressed in the earliest granule cell progenitors at the rhombic lip as they separate from the ventricular zone of the neural tube to generate a secondary proliferative matrix, and it continues to be expressed in differentiating and mature granule neurons [4].

Other interactions of Zscan21


Analytical, diagnostic and therapeutic context of Zscan21


  1. BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin. Yang, X.W., Wynder, C., Doughty, M.L., Heintz, N. Nat. Genet. (1999) [Pubmed]
  2. Embryonic precursor cells from the rhombic lip are specified to a cerebellar granule neuron identity. Alder, J., Cho, N.K., Hatten, M.E. Neuron (1996) [Pubmed]
  3. Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome. Yang, X.W., Model, P., Heintz, N. Nat. Biotechnol. (1997) [Pubmed]
  4. Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49. Yang, X.W., Zhong, R., Heintz, N. Development (1996) [Pubmed]
  5. Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis. Noce, T., Fujiwara, Y., Sezaki, M., Fujimoto, H., Higashinakagawa, T. Dev. Biol. (1992) [Pubmed]
  6. The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription. Chowdhury, K., Goulding, M., Walther, C., Imai, K., Fickenscher, H. Mech. Dev. (1992) [Pubmed]
  7. Tex27, a gene containing a zinc-finger domain, is up-regulated during the haploid stages of spermatogenesis. de Luis, O., López-Fernández, L.A., del Mazo, J. Exp. Cell Res. (1999) [Pubmed]
  8. Dexamethasone and triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, rapamycin and their analogues, as well as by other P-glycoprotein ligands. Marsaud, V., Mercier-Bodard, C., Fortin, D., Le Bihan, S., Renoir, J.M. J. Steroid Biochem. Mol. Biol. (1998) [Pubmed]
WikiGenes - Universities